Francis J. McMahon
A5091418738- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Adolescent and Pediatric Healthcare
- Tryptophan and brain disorders
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Treatment of Major Depression
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- BRCA gene mutations in cancer
- Genetic Neurodegenerative Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
- Congenital heart defects research
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Stress Responses and Cortisol
National Institute of Mental Health
2016-2025
National Institutes of Health
2016-2025
United States Department of Health and Human Services
2015-2024
Institute of Human Genetics
2024
Dokkyo Medical University
2024
National Institute of Mental Health
2004-2023
National Institute of Mental Health
2019-2023
Genomics (United Kingdom)
2022
Spitalul Clinic de Psihiatrie Alexandru Obregia
2021
Center for Behavioral Brain Sciences
2021
Nine cancer patients were treated with adoptive cell therapy using autologous anti-MAGE-A3 T-cell receptors (TCR)-engineered T cells. Five experienced clinical regression of their cancers including 2 on-going responders. Beginning 1–2 days postinfusion, 3 (#'s 5, 7, and 8) mental status changes, (5 lapsed into comas subsequently died. Magnetic resonance imagining analysis 5 8 demonstrated periventricular leukomalacia, examination brains at autopsy revealed necrotizing leukoencephalopathy...
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Neuroinflammation is a pathological hallmark of Alzheimer's disease, but its role in cognitive impairment and course development during the disease are largely unknown. To address these unknowns, we used positron emission tomography with 11C-PBR28 to measure translocator protein 18 kDa (TSPO), putative biomarker for inflammation. Patients patients mild older control subjects were also scanned 11C-Pittsburgh Compound B amyloid burden. Twenty-nine amyloid-positive (19 Alzheimer's, 10...
Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups homozygous high-affinity state (HH), low-affinity (LL), or heterozygous (HL). We tested if in vitro to leukocytes distinguished TSPO genotypes and genotype could affect clinical studies using radioligand [ 11 C]PBR28. In C]PBR28 brain imaging were performed 27 human subjects with known genotype....
A report on an initial genome screen 540 individuals in 97 families was collected as part of the NIMH Genetics Initiative Bipolar Disorder. Families were ascertained to be informative for genetic linkage and underwent a common ascertainment assessment protocol at four clinical sites. The sample genotyped 65 highly polymorphic markers from chromosomes 1, 6, 8, 10, 12. average intermarker interval 16 cM. Genotypic data analyzed using affected sib pair, multipoint pedigree analysis methods....
The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be involved in antidepressant drug treatment outcome, although response rates with antidepressants can lower patients who experience adverse effects.To test hypothesis that HTTLPR is associated outcome to citalopram.A clinical effectiveness trial, Sequenced Treatment Alternatives Relieve...
Suicidal ideation is an uncommon symptom than can emerge during antidepressant treatment. The biological basis of treatment-emergent suicidal unknown. Genetic markers may shed light on the causes and help identify individuals at high risk who benefit from closer monitoring, alternative treatments, or specialty care.A clinically representative cohort outpatients with major depressive disorder enrolled in Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated...