Sarah Kittel‐Schneider
A5063823796- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Functional Brain Connectivity Studies
- Pregnancy and Medication Impact
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Breastfeeding Practices and Influences
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Amyotrophic Lateral Sclerosis Research
- Nitric Oxide and Endothelin Effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Memory and Neural Mechanisms
Universitätsklinikum Würzburg
2014-2025
University College Cork
2023-2025
APC Microbiome Institute
2024-2025
Cork University Hospital
2023-2025
Goethe University Frankfurt
2015-2024
University Hospital Frankfurt
2015-2024
University of Würzburg
2013-2024
University of Tübingen
2024
Genomics (United Kingdom)
2022
Klinik für Psychosomatik
2021
Fibromyalgia syndrome is a clinically well-characterized chronic pain condition of high socio-economic impact. Although the pathophysiology still unclear, there increasing evidence for nervous system dysfunction in patients with fibromyalgia syndrome. In this case-control study we investigated function and morphology small nerve fibres 25 Patients underwent comprehensive neurological neurophysiological assessment. We examined fibre by quantitative sensory testing pain-related evoked...
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
BackgroundAttention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than female individuals. We examined putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity higher burden of risk cases.MethodsWe analyzed genome-wide autosomal variants from the Psychiatric Genomics Consortium iPSYCH Project (n = 20,183 cases, n 35,191 controls) Swedish population register data 77,905 1,874,637...
For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium effectively augment antidepressant drugs treatment of refractory major depressive episodes prevent relapses recurrent unipolar depression. In contrast many psychiatric drugs, outlasted various...
Although psychiatric disorders are, to date, diagnosed on the basis of behavioral symptoms and course illness, interest in neurobiological markers has grown substantially recent years. However, current classification approaches are mainly based data from a single biomarker, making it difficult predict characterized by complex patterns symptoms.To integrate neuroimaging associated with multiple symptom-related neural processes demonstrate their utility context depression deriving predictive...
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
The underlying cellular mechanisms of catatonia, an executive "psychomotor" syndrome that is observed across neuropsychiatric diseases, have remained obscure. In humans and mice, reduced expression the structural myelin protein CNP associated with catatonic signs in age-dependent manner, pointing to involvement myelin-producing oligodendrocytes. Here, we showed cause low-grade inflammation white matter tracts, which marks a final common pathway Cnp-deficient other mutant mice minor...
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action incompletely understood, and prediction outcomes limited. In our previous multi-omics study Pharmacogenomics Bipolar Disorder (PGBD) sample combining transcriptomic genomic data, we found that focal adhesion, extracellular matrix (ECM), PI3K-Akt signaling networks were associated with response to lithium. this study, replicated results using network propagation methods in a genome-wide...
The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research using various approaches including genetics, imaging, clinical and animal models advanced our knowledge regarding NPDs, we still lack basic the underlying pathophysiological mechanisms. Moreover, there is an urgent need for highly effective therapeutics NPDs. Human induced pluripotent stem cells (hiPSCs)...