A5021664662- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Eating Disorders and Behaviors
- Maternal Mental Health During Pregnancy and Postpartum
- Cognitive Abilities and Testing
- Genetics and Neurodevelopmental Disorders
- Suicide and Self-Harm Studies
- Child Nutrition and Feeding Issues
- Genetic Associations and Epidemiology
- Adolescent and Pediatric Healthcare
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Birth, Development, and Health
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Personality Disorders and Psychopathology
- Health, Environment, Cognitive Aging
- Metabolism and Genetic Disorders
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Diabetes and associated disorders
- Infant Development and Preterm Care
Örebro University
2016-2025
Karolinska Institutet
2016-2025
University of Southampton
2024-2025
Indiana University Bloomington
2013-2024
Karolinska University Hospital
2004-2024
University of Gothenburg
1976-2024
Royal Edinburgh Hospital
2024
Örebro University Hospital
2018-2024
Umeå University
1992-2023
University of Manitoba
2023
<h3>Importance</h3> Autism spectrum disorder (ASD) aggregates in families, but the individual risk and to what extent this is caused by genetic factors or shared nonshared environmental remains unresolved. <h3>Objective</h3> To provide estimates of familial aggregation heritability ASD. <h3>Design, Setting, Participants</h3> A population-based cohort including 2 049 973 Swedish children born 1982 through 2006. We identified 37 570 twin pairs, 642 064 full sibling 432 281 maternal 445 531...
Mortality has been suggested to be increased in autism spectrum disorder (ASD).To examine both all-cause and cause-specific mortality ASD, as well investigate moderating role of gender intellectual ability.Odds ratios (ORs) were calculated for a population-based cohort ASD probands (n = 27,122, diagnosed between 1987 2009) compared with gender-, age- county residence-matched controls 2,672,185).During the observed period, 24,358 (0.91%) individuals general population died, whereas...
This study reanalyzes Swedish cohort data to assess the stability under alternative assumptions and models of a previous estimate heritability autism spectrum disorder.
Attention deficit-hyperactivity disorder (ADHD) is a common that has been associated with criminal behavior in some studies. Pharmacologic treatment available for ADHD and may reduce the risk of criminality.Using Swedish national registers, we gathered information on 25,656 patients diagnosis ADHD, their pharmacologic treatment, subsequent convictions Sweden from 2006 through 2009. We used stratified Cox regression analyses to compare rate criminality while were receiving medication, as...
Background Postpartum depression (PPD) can result in negative personal and child developmental outcomes. Only a few large population-based studies of PPD have used clinical diagnoses no study has examined how maternal history interacts with known risk factors. The objective this was to examine the impact on pre- perinatal Methods A nationwide prospective cohort all women live singleton births Sweden from 1997 through 2008 conducted. Relative (RR) within first year postpartum two-sided 95%...
Background No prior twin study has explored the heritability of clinically diagnosed attention deficit hyperactivity disorder (ADHD). Such studies are needed to resolve conflicting results regarding importance genetic effects for ADHD in adults. We aimed estimate relative contribution and environmental influences across lifespan with a specific focus on Method Information zygosity sex was obtained from 59514 twins born between 1959 2001 included nationwide population-based Swedish Twin...
The Swedish Twin Registry (STR) today contains more than 194,000 twins and 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or being of opposite sex. Of these, approximately 20,000, 25,000, 30,000 are monozygotic, same-sex dizygotic, opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, STR has been important epidemiological resource for study genetic environmental influences on a multitude traits, behaviors, diseases....
Studies have shown that attention-deficit/hyperactivity disorder (ADHD) is associated with transport accidents, but the magnitude of association remains unclear. Most important, it also unclear whether ADHD medication reduces this risk.To estimate between and risk serious accidents to explore extent which influences among patients ADHD.In total, 17,408 a diagnosis were observed from January 1, 2006, through December 31, 2009, for documented in Swedish national registers. The was estimated...
In youth, ADHD is more commonly diagnosed in males than females, but higher male-to-female ratios are found clinical versus population-based samples, suggesting a sex bias the process of receiving diagnosis ADHD. This study investigated differences severity and presentation symptoms, conduct problems, learning problems females with without clinically We then whether predictive associations these symptom domains on being treated for differed females. Parents 19,804 twins (50.64% male) from...
Preterm birth is associated with increased mortality and morbidity. However, previous studies have been unable to rigorously examine whether confounding factors cause these associations rather than the harmful effects of being born preterm.To estimate extent which between early gestational age offspring morbidity are result by using a quasi-experimental design, sibling-comparison approach, controlling for statistical covariates that varied within families.A population-based cohort study,...
<h3>Importance</h3> Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing at childbearing on offspring remain unclear, however, because inconsistent epidemiologic findings and inability previous studies to rigorously rule out confounding factors. <h3>Objective</h3> To examine associations between numerous indexes morbidity. <h3>Design, Setting,...
Background: Although the clinical utility of categorically defined attention‐deficit hyperactivity disorder (ADHD) is well established, there also strong evidence supporting notion ADHD as an extreme a continuous trait. Nevertheless, question whether etiology same for different levels DSM–IV symptoms remains to be investigated. The aim this study was assess genetic links between and subthreshold range symptoms. Method: Parents all Swedish 9‐ 12‐year‐old twins born 1992 2000 were interviewed...
Background Traumatic brain injury (TBI) is the leading cause of disability and mortality in children young adults worldwide. It remains unclear, however, how TBI childhood adolescence associated with adult mortality, psychiatric morbidity, social outcomes. Methods Findings In a Swedish birth cohort between 1973 1985 1,143,470 individuals, we identified all those who had sustained at least one (n = 104,290 or 9.1%) up to age 25 y their unaffected siblings 68,268) using patient registers. We...
Antipsychotics and mood stabilisers are prescribed widely to patients with psychiatric disorders worldwide. Despite clear evidence for their efficacy in relapse prevention symptom relief, effect on some adverse outcomes, including the perpetration of violent crime, is unclear. We aimed establish antipsychotics rate crime committed by Sweden.We used linked Swedish national registers study 82,647 who were or stabilisers, diagnoses, subsequent criminal convictions 2006-09. did within-individual...
BackgroundDepression increases the risk of a range adverse outcomes including suicide, premature mortality, and self-harm, but associations with violent crime remain uncertain. We aimed to determine risks in patients depression investigate association between depressive symptoms cohort twins.MethodsWe conducted two studies. The first was total population study Sweden outpatient diagnoses disorders (n=47 158) 2001 2009 no lifetime inpatient episodes. Patients were age sex matched general...
This study examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated either antidepressant monotherapy or an conjunction a mood stabilizer.Using Swedish national registries, authors identified 3,240 who started treatment and had no during previous year. Patients were categorized into those receiving plus stabilizer. A within-individual design was used to control for confounding by severity, genetic makeup, early environmental factors. Cox regression...
Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. The presence of a genetic link between ASD ADHD symptoms is supported by twin studies, but the overlap clinically ascertained remains largely unclear. We therefore investigated how co-aggregate in individuals families to test for shared liability examined potential differences low- high-functioning with ADHD. studied 1 899 654 born Sweden 1987 2006. Logistic regression was used estimate...
<h3>Importance</h3> Psychiatric disorders are heritable, polygenic traits, which often share risk alleles and for nonrandom mating has been suggested. However, despite the potential etiological implications, scale of within across major psychiatric conditions remains unclear. <h3>Objective</h3> To quantify nature extent a broad range at population level. <h3>Design, Setting, Participants</h3> Population-based cohort using Swedish registers. Participants were all residents with diagnosis...