Georg Ziegler
A5091844335- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Law and Political Science
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- CRISPR and Genetic Engineering
- Neural and Behavioral Psychology Studies
- Genomic variations and chromosomal abnormalities
- Pluripotent Stem Cells Research
- Hemispheric Asymmetry in Neuroscience
- Retinal Imaging and Analysis
- Birth, Development, and Health
- Medical and Health Sciences Research
- Obsessive-Compulsive Spectrum Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Receptor Mechanisms and Signaling
- Public Administration and Political Analysis
- Digitalization, Law, and Regulation
- Sociology and Education Studies
- Family Support in Illness
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
University of Würzburg
2017-2024
Universitätsklinikum Würzburg
2019-2024
FH Aachen
2022
Radboud University Nijmegen
2019
Radboud University Medical Center
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Sunovion (United States)
2019
Technical University of Munich
2017
Hochschule Aalen
2000
Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related ADHD using large-scale studies. Methods: Cortical thickness surface area (based on the Desikan–Killiany atlas) were compared between case subjects (N=2,246) control (N=1,934) for children, adolescents, separately ENIGMA-ADHD, a...
Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings been contradictory and based on small samples. Here, we performed the largest ever analysis left-right ADHD, using 39 datasets ENIGMA consortium.
The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research using various approaches including genetics, imaging, clinical and animal models advanced our knowledge regarding NPDs, we still lack basic the underlying pathophysiological mechanisms. Moreover, there is an urgent need for highly effective therapeutics NPDs. Human induced pluripotent stem cells (hiPSCs)...
Abstract Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated loci, including the first linked to midbrain, pons, medulla oblongata volumes, map them 305 genes. In replication 7432 participants most loci show same effect direction are significant at nominal threshold. We detect overlap...
Numerous genetic and environmental factors contribute to psychiatric disorders other brain disorders. Common risk likely converge on biological pathways regulating the optimization of structure function across lifespan. Here, using structural magnetic resonance imaging machine learning, we estimated gap between age chronological in 36,891 individuals aged 3 96 years, including with different We show that several are associated accentuated aging, strongest effects schizophrenia, multiple...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental with complex genetic background, hampering identification of underlying risk factors. We hypothesized that combining linkage analysis and whole-exome sequencing (WES) in multi-generation pedigrees multiple affected individuals can point toward novel ADHD genes. Three families ADHD-affected members ( N total = 70) apparent dominant inheritance pattern were included this study. Genotyping was performed 37...
The cell—cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. regulates axonal outgrowth synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence on personality traits, behavior, executive functions. However, evidence functional effects common variation in humans sparse. Therefore, we tested association...
Abstract KCNJ6 , encoding a potassium channel subunit, regulates the excitability of dopaminergic neurons and is expressed in attention‐deficit/hyperactivity disorder (ADHD)‐relevant brain regions. As potential ADHD risk gene, therefore, may contribute to endophenotypic variation disorder. The impact two SNPs, rs7275707 rs6517442, both located transcriptional control region on reporter gene expression was explored cultured cells. variants were then tested for association with personality...
Abstract Human induced pluripotent stem cells (hiPSCs) have revolutionized the generation of experimental disease models, but development protocols for differentiation functionally active neuronal subtypes with defined specification is still in its infancy. While dysfunction brain serotonin (5-HT) system has been implicated etiology various neuropsychiatric disorders, investigation functional human 5-HT specific neurons vitro restricted by technical limitations. We describe an efficient from...
Fibroblasts were isolated from a skin biopsy of clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying duplication SLC2A3, gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibroblasts infected with Sendai virus, single-stranded RNA to generate transgene-free human induced pluripotent stem cells (iPSCs). SLC2A3-D2-iPSCs showed expression pluripotency-associated markers, able differentiate into the three germ layers in vitro and...
Abstract Transcranial direct current stimulation (tDCS) is a non-invasive brain treatment used as an alternative or complementary for various neuropsychiatric disorders, and could be add-on therapy to psychostimulants in attention-deficit hyperactivity disorder (ADHD). Previous studies provided some evidence improvements cognition clinical symptoms pediatric adult ADHD patients. However, data from multi-center randomized controlled trials (RCTs) this condition are lacking. Thus, our aim...
Posterior cortical atrophy (PCA) describes a rare heterogenous neurodegenerative syndrome with early visuospatial and visuoperceptual deficits due to of parieto-occipital brain regions. Here, we describe the case 62-year-old woman showing severe cognitive impairments as well hemianopsia all core symptoms Bálint's syndrome. Years ago, patient had complained about “tunnel view” concentration problems. The diagnostic results point PCA underlying Alzheimer pathology. disease course until...
Adult ADHD is associated with increased risk for suicide attempts, as indicated by investigations of population- and community-based cohorts. However, there little data regarding attempts in a clinical setting. To address this, we used comprehensively phenotyped adult (aADHD) cohort to assess which extent comorbidity, psychosocial adversity, personality, symptoms contribute suicidal behavior ADHD. Furthermore, investigated triallelic variation the serotonin transporter-linked polymorphic...