A5041446559- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Immune Response and Inflammation
- Reproductive tract infections research
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- S100 Proteins and Annexins
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Preterm Birth and Chorioamnionitis
- Myasthenia Gravis and Thymoma
- Cell Adhesion Molecules Research
- Ocular Diseases and Behçet’s Syndrome
- Caveolin-1 and cellular processes
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Health and Medical Studies
- Neonatal and fetal brain pathology
- Sarcoidosis and Beryllium Toxicity Research
- Brain Metastases and Treatment
- Prion Diseases and Protein Misfolding
Universitätsklinikum Würzburg
2018-2023
University of Würzburg
2010-2023
Klinik und Poliklinik für Neurologie
2022
Heinrich Heine University Düsseldorf
1995-2021
St. Josef-Hospital
2021
European Neuroendocrine Tumor Society
2020
Humboldt State University
2019
Otto-von-Guericke University Magdeburg
2012
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
Auto-antibodies against the paranodal proteins neurofascin-155 and contactin-1 have recently been described in patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated a distinct clinical phenotype response to treatment. Contactin-associated protein 1 (Caspr, encoded by CNTNAP1 ) is that attached (CNTN1) but has not yet identified as sole antigen neuropathies. In present study, we screened cohort of 35 (age range 20–80, 10 female, 25 male) 22 Guillain-Barré...
<h3>Background and Objectives</h3> To evaluate the long-term safety efficacy of tocilizumab (TCZ), a humanized anti–interleukin-6 receptor antibody in myelin oligodendrocyte glycoprotein–IgG–associated disease (MOGAD) neuromyelitis optica spectrum disorders (NMOSD). <h3>Methods</h3> Annualized relapse rate (ARR), Expanded Disability Status Scale score, MRI, autoantibody titers, pain, adverse events were retrospectively evaluated 57 patients with MOGAD (n = 14), aquaporin-4 (AQP4)-IgG...
Human brain microvascular endothelial cells forming the blood-brain barrier (BBB) release soluble vascular cell adhesion molecule-1 (sVCAM-1) under inflammatory conditions. Furthermore, sVCAM-1 serum levels in untreated patients with multiple sclerosis (MS) correlate a breakdown of BBB as measured by gadolinium-enhanced MRI. To date, it is unknown whether itself modulates permeability. Here, we provide evidence that human endothelium expresses integrin α-4/β-1, molecular binding partner...
Abstract Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new subtype of nodo-paranodopathy. It relevant because it high morbidity and mortality. Affected patients often require intensive care unit treatment for several months, data on the reversibility long-term prognosis are limited. The pathogenicity including IgG subclass-associated mechanisms has not been unravelled, nor directly compared to anti-neurofascin-155 IgG4-related pathology. Understanding...
Abstract Objective Progression prediction is a significant unmet need in people with progressive multiple sclerosis (pwPMS). Studies on glial fibrillary acidic protein (GFAP) have either been limited to single center relapsing MS or were based solely Expanded Disability Status Scale (EDSS), which limits its generalizability state‐of‐the‐art clinical settings and trials applying combined outcome parameters. Methods Serum GFAP NfL (neurofilament light chain) investigated EmBioProMS...
To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks.A total 548 longitudinally assessed full-field evoked potentials (VEP) 167 NMOSD from 16 centers were retrospectively evaluated for changes P100 latencies and P100-N140 amplitudes. Rates change in (RCL) amplitudes (RCA) over time analyzed each individual eye using linear regression compared generalized estimating equation models.The rates...
Chemokines (C-X-C) motif ligand (CXCL) 5 and 8 are overexpressed in patients with multiple sclerosis, where CXCL5 serum levels were shown to correlate blood–brain barrier dysfunction as evidenced by gadolinium-enhanced magnetic resonance imaging. Here, we studied the potential role of CXCL5/CXCL8 receptor 2 (CXCR2) a regulator paraendothelial brain function, using well-characterized human cerebral microvascular endothelial cell line hCMEC/D3. Low basal CXCR2 mRNA protein expression hCMEC/D3...
Background An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation vascular beds. Here we studied the regulation JAM-A expression brain EC evaluated as a biomarker blood-brain barrier (BBB) function. Methodology/Principal Findings As previously reported types, stimulation primary or immortalized (hCMEC/D3) human...
Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and neonates, including neonatal meningitis. The interactions of spp. with host defense mechanisms poorly understood. This study addressed Ureaplasma-driven cell death, concentrating on apoptosis well inflammatory death. Human brain microvascular endothelial cells (HBMEC) were exposed to (U.) urealyticum serovar 8 (Uu8) U. parvum 3 (Up3). Resulting numbers...
Now that mechanical thrombectomy has substantially improved outcomes after large-vessel occlusion stroke in up to every second patient, futile reperfusion wherein successful recanalization is not followed by a favorable outcome moving into focus. Unfortunately, blood-based biomarkers, which identify critical stages of hemodynamically compromised yet reperfused tissue, are lacking. We recently reported hypoxia induces the expression endoglin, TGF-β co-receptor, human brain endothelium vitro....
Objectives : Detection and prediction of disability progression is a significant unmet need in people with progressive multiple sclerosis (PwPMS). Government health agencies have deemed the use patient-reported outcomes measures (PROMs) clinical practice trials major strategic priority. Nevertheless, data documenting utility PROMs neurological diseases scarce. This study evaluates if assessment could track PwPMS. Methods EMerging blood BIOmarkers PROgressive Multiple Sclerosis (EmBioProMS)...
Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized several neurological autoimmune diseases, neuroinflammation also result from infectious agents, including Ureaplasma species (spp.). Although commonly regarded as commensals the adult urogenital...
Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers the differential diagnosis of demyelination. Here, we report on discovery autoantibodies flotillin patients with multiple sclerosis (MS). The target antigen was identified by histo-immunoprecipitation using patients' sera cryosections rat or pig cerebellum combined mass spectrometrical analysis. Correct identification ascertained indirect immunofluorescence neutralization...
Dimethyl fumarate (DMF) is approved for disease-modifying treatment of patients with relapsing-remitting multiple sclerosis. Animal experiments suggested that part its therapeutic effect due to a reduction T-cell infiltration the central nervous system (CNS) by uncertain mechanisms. Here we evaluated whether DMF and primary metabolite monomethyl (MMF) modulate pro-inflammatory intracellular signaling adhesiveness nonimmortalized single donor human brain microvascular endothelial cells at low...
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but associated bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition the NLRP3 inflammasome led to preserved blood-brain barrier (BBB) integrity in experimental vivo. To further address potential as adjunct we used immortalized brain derived endothelial cells (bEnd5) an vitro model BBB. We treated bEnd5 rt-PA combination specific...
In large vessel occlusion stroke, recanalization to restore cerebral perfusion is essential but not necessarily sufficient for a favorable outcome. Paradoxically, in some patients, reperfusion carries the risk of increased tissue damage and hemorrhage. Experimental clinical data suggest that endothelial cells, representing interface detrimental platelet leukocyte responses, likely play crucial role phenomenon referred as ischemia/reperfusion (I/R)-injury, mechanisms are unknown. We aimed...
Ureaplasma species (spp.) are considered commensals of the adult genitourinary tract, but have been associated with chorioamnionitis, preterm birth, and invasive infections in neonates, including meningitis. Data on mechanisms involved Ureaplasma-driven neuroinflammation scarce. The present study addressed brain inflammatory responses lambs exposed to parvum (UP) utero. 7 days after intra-amniotic injection UP (n = 10) or saline 11), were surgically delivered at gestational day 128-129....