A5086459629- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Autoimmune Neurological Disorders and Treatments
- Retinal Imaging and Analysis
- Long-Term Effects of COVID-19
- Retinal Development and Disorders
- Amyotrophic Lateral Sclerosis Research
- Reproductive System and Pregnancy
- Pain Mechanisms and Treatments
- Research on Leishmaniasis Studies
- Neurological Complications and Syndromes
- Hereditary Neurological Disorders
- Neurological and metabolic disorders
- Sphingolipid Metabolism and Signaling
- Ion channel regulation and function
- Infectious Encephalopathies and Encephalitis
- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Parkinson's Disease Mechanisms and Treatments
Heinrich Heine University Düsseldorf
2012-2022
Hospital zum Heiligen Geist
2020-2021
Palacký University Olomouc
2021
Medical University of Vienna
2021
The University of Sydney
2021
Humboldt State University
2019
Düsseldorf University Hospital
2014-2018
Charité - Universitätsmedizin Berlin
2015
University Medical Center
2015
University Medical Center of the Johannes Gutenberg University Mainz
2015
Neuromyelitis optica (NMO) is characterized by disabling relapses of optic neuritis and myelitis the presence aquaporin 4 antibodies (AQP4-abs). Interleukin 6, which significantly elevated in serum cerebrospinal fluid patients with NMO, induces AQP4-ab production plasmablasts represents a novel therapeutic target.To evaluate long-term safety efficacy tocilizumab, humanized antibody targeting interleukin 6 receptor, NMO spectrum disorder.Retrospective observational study 10 to 51 months...
Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and part conflicting data exists on different subtypes. Objective. To analyse patterns changes subtypes with latest spectral-domain technology. Methods. In a three-centre cross-sectional study 414 patients 94 healthy controls underwent OCT examination. Results. Eyes without previous optic neuritis showed significant reduction both nerve fibre layer (RNFL)...
Background: Axonal and neuronal damage are widely accepted as key events in the disease course of multiple sclerosis. However, it has been unclear to date at which stage evolution neurodegeneration begins whether can occur even absence acute inflammatory attacks. Objective: To characterize inner retinal layer changes patients with clinically isolated syndrome (CIS). Method: 45 CIS age- sex-matched healthy controls were investigated using spectral domain optical coherence tomography....
Amyotrophic lateral sclerosis (ALS) is characterized by neuro-ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (n = 20) or probable 4) ALS compared to matched controls. High-resolution spectral domain optical coherence tomography segmentation revealed subtle reduction the macular thickness nerve fiber layer (RNFL) well marked thinning...
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
The aim of this non-interventional study was to characterize retinal layer pathology in Susac syndrome (SuS), a disease with presumably autoimmune-mediated microvessel occlusions the retina, brain, and inner ear, comparison most important differential diagnosis multiple sclerosis (MS).Seventeen patients SuS 17 age- sex-matched relapsing-remitting MS (RRMS) healthy controls (HC) were prospectively investigated by spectral-domain optical coherence tomography (OCT) including intraretinal...
Neuromyelitis optica (NMO) predominantly affects women, some in childbearing age, and requires early therapeutic intervention to prevent disabling relapses. We report an anti-AQP4 antibody-seropositive patient who became pregnant seven months after low-dose (100 mg) rituximab application. Pregnancy showed no complications, restarted two days delivery resulted neurological stability for 24 months. Remarkably, her otherwise healthy newborn presented with antibody reduced B lymphocyte counts...
To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks.A total 548 longitudinally assessed full-field evoked potentials (VEP) 167 NMOSD from 16 centers were retrospectively evaluated for changes P100 latencies and P100-N140 amplitudes. Rates change in (RCL) amplitudes (RCA) over time analyzed each individual eye using linear regression compared generalized estimating equation models.The rates...
To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as infarctions or the congenital morning glory anomaly may have subtle subclinical changes.In this cross-sectional study, spectral domain optical coherence tomography was used to analyze morphology of 25 idiopathic and age- sex-matched healthy controls. We analyzed vasculature blue laser autofluorescence, lipofuscin deposits MultiColor confocal scanning ophthalmoscopy, optic nerve head (ONH)...
Neuromyelitis optica (NMO) is a severely disabling inflammatory disorder of the central nervous system and often misdiagnosed as multiple sclerosis (MS). There increasing evidence that treatment options shown to be beneficial in MS, including interferon-β (IFN-β), are detrimental NMO. We here report first Caucasian patient with aquaporin 4 (AQP4) antibody (NMO-IgG)-seropositive NMO presenting tumefactive brain lesion on IFN-β. Disease started relapsing optic neuritis an episode...
Studies using conventional full-field visual evoked potentials (ffVEP) have reported subtle abnormalities in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesize that these can be detected the majority of CIDP enhanced methods.We performed a cross-sectional noninterventional study comparing 18 and matched healthy controls multifocal VEP (mfVEP) as technique sensitivity to detect conduction across spectrum optic nerve fibers. Patients confounding diseases...
We read with great interest the publication by Schellekens et al.1 providing insights into a case of postinfectious myoclonus combined cerebellar ataxia after SARS-CoV-2 infection. Three other COVID-19 patients were summarized in same issue Movement Disorder Clinical Practice. All whom had severe respiratory symptoms and required intensive care.2 further myoclonus-cases mostly manifestation reported elsewhere.3 However, al. point out that can also occur minor affected patients. Common most...
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease primarily affecting the peripheral nervous system. However, several noncontrolled studies have suggested concomitant CNS demyelination similar to multiple sclerosis. The aim of this study was investigate involvement visual pathway in patients with CIDP.In prospective cross-sectional study, we used high-resolution spectral-domain optical coherence tomography compare thickness peripapillary retinal nerve fiber...
Background: Visual field defects are a common and disabling consequence of stroke negative prognostic factor patient's quality life. They result from lesions in different parts the visual system, most commonly cortex optic radiation. An important pathophysiological mechanism is transsynaptic retrograde degeneration (TRD). Methods: In case series 21 patients with posterior cerebral artery (PCA) territory infarctions were analyzed by spectral-domain optical coherence tomography (SD-OCT)...