Carolin Baade‐Büttner
A5064211384- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Chronic Lymphocytic Leukemia Research
- Neurogenesis and neuroplasticity mechanisms
- DNA Repair Mechanisms
- Genetic Neurodegenerative Diseases
- Cellular transport and secretion
- Genomics and Rare Diseases
- Neonatal and fetal brain pathology
- Carcinogens and Genotoxicity Assessment
- Immunodeficiency and Autoimmune Disorders
- Genomic variations and chromosomal abnormalities
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
Jena University Hospital
2022-2024
Leipzig University
2019
<h3>Background and Objectives</h3> To determine the real-world use of rituximab in autoimmune encephalitis (AE) to correlate treatment with long-term outcome. <h3>Methods</h3> Patients NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from GErman Network for Research on AuToimmune Encephalitis who had received at least 1 dose a control cohort non–rituximab-treated patients...
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, long-term cognitive dysfunction. We identified microglia C1q complement activation in hippocampal autopsy tissue patients with increased C1q-mediated synaptic pruning murine polymicrobial model. Unbiased transcriptomics isolated derived from septic mice revealed an involvement the innate immune system, activation, up-regulation lysosomal pathways during SAE parallel to neuronal...
Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two...
Abstract Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of glutamic acid decarboxylase (GAD65) present limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis ataxia, and stiff-person-syndrome overlap forms. Anti-GAD65 are also detected in autoimmune diabetes mellitus, which has a strong genetic susceptibility conferred by human leukocyte antigen (HLA) non-HLA genomic regions. We investigated predisposition patients anti-GAD65...
Microglia are innate immune cells in the brain and show exceptional heterogeneity. They key players physiological development regulating synaptic plasticity shaping neuronal networks. In pathological disease states, microglia-induced pruning mediates loss targeting microglia was proposed as a promising therapeutic strategy. However, effect of depletion subsequent repopulation on dendritic spine density function adult is largely unknown. this study, we investigated whether pharmacological...
MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components compromises cell life. Mutations cause human genomic instability syndromes Ataxia-Telangiectasia-like disorder (A-TLD), NBS-like (NBSLD), Nijmegen Breakage Syndrome (NBS), respectively. Among other pathologies, neuronal deficits, including microcephaly, intellectual disabilities, progressive cerebellar degeneration, are common these...
Abstract Background Deciphering the monogenetic causes of neurodevelopmental disorders (NDD) is an important milestone to offer personalized care. But plausibility reported candidate genes in exome studies often remains unclear, which slows down progress field. Methods We performed sequencing (ES) 198 cases NDD. Cases that remained unresolved (n=135) were re-investigated a research setting. established scoring system (CaSc) based on 12 different parameters reflecting variant and gene...