About
Contact & Profiles
A5092030076
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
Jena University Hospital
2023
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, long-term cognitive dysfunction. We identified microglia C1q complement activation in hippocampal autopsy tissue patients with increased C1q-mediated synaptic pruning murine polymicrobial model. Unbiased transcriptomics isolated derived from septic mice revealed an involvement the innate immune system, activation, up-regulation lysosomal pathways during SAE parallel to neuronal...
10.1126/sciadv.abq7806
article
EN
cc-by-nc
Science Advances
2023-05-26
10.1016/j.imbio.2023.152596
article
EN
Immunobiology
2023-08-25
Coming Soon ...