A5092030075- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Electroconvulsive Therapy Studies
- Neonatal and fetal brain pathology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Treatment of Major Depression
- Intensive Care Unit Cognitive Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
Jena University Hospital
2023-2025
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, long-term cognitive dysfunction. We identified microglia C1q complement activation in hippocampal autopsy tissue patients with increased C1q-mediated synaptic pruning murine polymicrobial model. Unbiased transcriptomics isolated derived from septic mice revealed an involvement the innate immune system, activation, up-regulation lysosomal pathways during SAE parallel to neuronal...
A 21-year-old Caucasian woman was admitted to our neurologic intermediate care unit after attempting suicide by ingesting an estimated 15 g venlafaxine (Trevilor retard ® ), adding up a serum concentration of approximately 17,943 μg/l. Brain magnetic resonance imaging (MRI) revealed bilateral cortical restricted-diffusion patterns, indicating ischemic lesions. We report case venlafaxine-induced serotonin syndrome most likely cumulating in diffuse artery vasospasm due autonomic effect...
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and associated with poor outcome in the early phase sepsis. In addition, sepsis survivors often suffer from persisting memory deficits executive functions. Recent studies provide evidence that microglia are involved pathophysiology SAE.Here, we investigated whether pharmacological depletion using PLX5622 (1200 ppm 300 ppm) acute able to prevent...
Microglia are innate immune cells in the brain and show exceptional heterogeneity. They key players physiological development regulating synaptic plasticity shaping neuronal networks. In pathological disease states, microglia-induced pruning mediates loss targeting microglia was proposed as a promising therapeutic strategy. However, effect of depletion subsequent repopulation on dendritic spine density function adult is largely unknown. this study, we investigated whether pharmacological...