Theodor Rüber
A5091217168- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- RNA regulation and disease
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Cerebral Palsy and Movement Disorders
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Infectious Encephalopathies and Encephalitis
- Neonatal and fetal brain pathology
- Brain Tumor Detection and Classification
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Neuropathies and Disorders
- Atomic and Subatomic Physics Research
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Music Perception
- Pharmacological Effects and Toxicity Studies
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
University Hospital Bonn
2016-2025
University of Bonn
2017-2025
German Center for Neurodegenerative Diseases
2024-2025
Heidelberg University
2024
University Hospital Heidelberg
2024
National Hospital for Neurology and Neurosurgery
2024
University College London
2024
Weatherford College
2024
Humboldt State University
2024
Goethe University Frankfurt
2019-2023
Structure and function of the human brain are affected by training in both linguistic musical domains. Individuals with intensive vocal provide a useful model for investigating neural adaptations learning vocal-motor domain can be compared more general domain. Here we confirm differences macrostructure (tract volume) microstructure (fractional anisotropy, FA) arcuate fasciculus (AF), prominent white-matter tract connecting temporal frontal regions, between singers, instrumentalists,...
Abstract Electrophysiological and neuroimaging studies suggest that the integrity of ipsilesional inter‐hemispheric motor circuits is important for recovery after stroke. However, extent to which each these tracts contributes variance in outcome remains unclear. We examined whether diffusion tensor imaging (DTI)‐derived measures corticospinal transcallosal predict improvement an experimental neurorehabilitation trial. 15 chronic stroke patients received bihemispheric transcranial direct...
Music making (playing an instrument or singing) is a multimodal activity that involves the integration of auditory and sensorimotor processes. The ability to sing in humans evident from infancy, does not depend on formal vocal training but can be enhanced by training. Given behavioral similarities between singing speaking, as well shared distinct neural correlates both, researchers have begun examine whether used treat some speech-motor abnormalities associated with various neurological...
Studies on nonhuman primates have demonstrated that the cortico-rubro-spinal system can compensate for damage to pyramidal tract (PT). In humans, so-called alternate motor fibers (aMF), which may comprise tract, been suggested play a similar role in recovery after stroke. Using diffusion tensor imaging, we examined PT and aMF context of human by relating their microstructural properties functional outcome chronic stroke patients.PT were reconstructed based origins primary motor, dorsal...
Epilepsy has been associated with a dysfunction of the blood-brain barrier. While there is ample evidence that barrier contributes to epileptogenesis, as consequence single epileptic seizures not systematically investigated. We hypothesized temporally and anatomically in patients used newly-established quantitative MRI protocol test our hypothesis. Twenty-three epilepsy undergoing inpatient monitoring part their presurgical evaluation were included this study (10 females, mean age ± standard...
Abstract Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients epilepsy related findings to postmortem gene expression patterns. Brain analysis included 578 adults temporal lobe (TLE), 288 idiopathic generalized (IGE), 1328 healthy controls from 18 centres...
Radiological identification of temporal lobe epilepsy (TLE) is crucial for diagnosis and treatment planning. TLE neuroimaging abnormalities are pervasive at the group level, but they can be subtle difficult to identify by visual inspection individual scans, prompting applications artificial intelligence (AI) assisted technologies.
Abstract Objective The intricate neuroanatomical structure of the cerebellum is longstanding interest in epilepsy, but has been poorly characterized within current corticocentric models this disease. We quantified cross‐sectional regional cerebellar lobule volumes using structural magnetic resonance imaging 1602 adults with epilepsy and 1022 healthy controls across 22 sites from global ENIGMA‐Epilepsy working group. Methods A state‐of‐the‐art deep learning‐based approach was employed that...
Abstract Objective Focal cortical dysplasias (FCDs) are a common cause of drug‐resistant focal epilepsy but frequently remain undetected by conventional magnetic resonance imaging (MRI) assessment. The visual detection can be facilitated morphometric analysis T1‐weighted images, for example, using the Morphometric Analysis Program (v2018; MAP18), which was introduced in 2005, independently validated its clinical benefits, and successfully integrated standard presurgical workflows numerous...
Abstract Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, date, alterations metabolism brain have not been addressed detail. Iron-related neuropathology and antioxidant metabolic processes were investigated resected tissue from patients temporal lobe epilepsy hippocampal sclerosis (TLE-HS), post-mortem who died after status epilepticus (SE) as...
Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or imaging findings. Brain magnetic resonance (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role machine learning and artificial increase brain abnormalities TLE remains inconclusive. We used support vector (SV) deep (DL) models region interest (ROI-based) structural (n = 336) diffusion 863) MRI data from...
Automated detection of lesions using artificial intelligence creates new standards in medical imaging. For people with epilepsy, automated focal cortical dysplasias (FCDs) is widely used because subtle FCDs often escape conventional neuroradiological diagnosis. Accurate recognition FCDs, however, outstanding importance for affected people, as surgical resection the dysplastic cortex associated a high chance postsurgical seizure freedom. Here, we make publicly available dataset 85 by epilepsy...
Between-group comparisons of musicians and nonmusicians have revealed structural brain differences also functional in motor performance. In this study, we aimed to examine the relation between white matter microstructure high-level skills by contrasting 2 groups with different instrument-specific requirements. We used diffusion tensor imaging compare diffusivity measures corticospinal tracts 10 keyboard players, string nonmusicians. Additionally, maximal tapping rates their left right index...
Our objective was to evaluate the diagnostic performance of a convolutional neural network (CNN) trained on multiple MR imaging features lumbar spine, detect variety different degenerative changes spine. One hundred and forty-six consecutive patients underwent routine clinical MRI spine including T2-weighted were retrospectively analyzed using CNN for detection labeling vertebrae, disc segments, as well presence herniation, bulging, spinal canal stenosis, nerve root compression,...
Abstract Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of glutamic acid decarboxylase (GAD65) present limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis ataxia, and stiff-person-syndrome overlap forms. Anti-GAD65 are also detected in autoimmune diabetes mellitus, which has a strong genetic susceptibility conferred by human leukocyte antigen (HLA) non-HLA genomic regions. We investigated predisposition patients anti-GAD65...
Abstract Objective Interictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated animal models and pathological specimens. Ictal shown humans vivo using an experimental quantitative magnetic resonance imaging (MRI) protocol. Here, we hypothesized that interictal is also present people with drug‐resistant epilepsy. Methods Thirty‐nine (21 females, mean age at MRI ± SD = 30 8 years) were prospectively recruited underwent T1‐relaxometry before after administration of a...
Abstract Resection cavities, tumors, and other lesions can fundamentally alter brain structure present as abnormalities in MRI. Specifically, quantifying subtle neuroanatomical changes other, not directly affected regions of the is essential to assess impact surgery, chemo/radiotherapy, or drug treatments. However, only a limited number solutions address this important task, while many standard analysis pipelines simply do support abnormal images at all. In paper, we method perform sensitive...
A bstract Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated a complex genetic architecture, but the translation from risk factors to brain vulnerability remains unclear. Here, we examined associations between epilepsy-related polygenic scores for HS (PRS-HS) and structure in large sample of neurotypical children, correlated these signatures case-control findings multicentric cohorts patients TLE-HS. Imaging-genetic analyses revealed PRS-related cortical thinning...
Despite decades of advancements in diagnostic MRI, 30-50% temporal lobe epilepsy (TLE) patients remain categorized as "non-lesional" (i.e., MRI negative or MRI-) based on visual assessment by human experts. MRI- face uncertainty and significant delays treatment planning. Quantitative studies have demonstrated that often exhibit a TLE-specific pattern limbic atrophy may be too subtle for the eye to detect. This signature could successfully translated into clinical use via artificial...
Abstract The detection of transient peri‐ictal magnetic resonance imaging (MRI) abnormalities has been variable after epileptic seizures. most common reason for this variability is that may disappear if the interval between seizure and scan acquisition prolonged using conventional high‐field systems. Here, we deployed a portable ultra‐low‐field MRI system in presurgical evaluation at bedside individuals with epilepsy. We hypothesized novel technology enables rapid postictal scans reliably...
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...