A5000884026- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Non-Invasive Vital Sign Monitoring
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Traumatic Brain Injury Research
- Tuberous Sclerosis Complex Research
- Vascular Malformations Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
University College London
2016-2025
Great Ormond Street Hospital
2016-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2014-2025
National Health Service
2021-2025
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Hospices Civils de Lyon
2022
Hôpital Femme Mère Enfant
2022
Institute of Child Health
2021
National Hospital for Neurology and Neurosurgery
2005-2020
Computer-assisted planning (CAP) allows faster SEEG and improves grey matter sampling, orthogonal drilling angles to the skull, reduces risk scores minimises intracerebral electrode length. Incorporating prior trajectories enhances CAP planning, refining output with centre-specific practices. This study significantly expands on previous work, compares priors libraries between two centres, describes differences in adults children these centres. 98 61 who underwent implantation as part of...
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Drug-resistant focal epilepsy is often caused by cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and impact lesion location on clinical presentation surgical outcome are largely unknown. We created a neuroimaging cohort patients with individually mapped FCDs to determine factors associated predictors postsurgical outcome.
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
Neurosurgery is a safe and effective form of treatment for select children with drug-resistant epilepsy. Still, there concern that it remains underutilized, seizure freedom rates have not improved over time. We investigated referral surgical practices, patient characteristics, postoperative outcomes the past two decades.
Neuropsychological impairments are common in children with drug-resistant epilepsy. It has been proposed that epilepsy surgery might alleviate these by providing seizure freedom; however, findings from prior studies have inconsistent. We mapped long-term neuropsychological trajectories before and after undergoing surgery, to measure the impact of disease course on functioning. performed a retrospective cohort study 882 who had undergone at Great Ormond Street Hospital (1990-2018). extracted...
Traumatic brain injury (TBI) is associated with depressed aerobic metabolism and mitochondrial dysfunction. Normobaric hyperoxia (NBH) has been suggested as a treatment for TBI, but studies in humans have produced equivocal results. In this study the authors used tissue O(2) tension measurement, cerebral microdialysis, near-infrared spectroscopy to effects of NBH after TBI. They investigated on cellular redox states measured by lactate/pyruvate ratio (LPR) change oxidized cytochrome c...
Traumatic brain injury causes diffuse axonal and loss of cortical neurons. These features are well recognized histologically, but their in vivo monitoring remains challenging. In microdialysis samples the extracellular fluid adjacent to neurons axons. Here, we describe a novel neuronal proteolytic pathway demonstrate exclusive neuro-axonal expression Pavlov's enterokinase. Enterokinase is membrane bound cleaves neurofilament heavy chain at positions 476 986. Using 100 kDa cut-off two...
In the evaluation of Stereo-Electroencephalography (SEEG) signals, physicist's workflow involves several operations, including determining position individual electrode contacts in terms both relationship to grey or white matter and location specific brain regions. These operations are (i) generally carried out manually by experts with limited computer support, (ii) hugely time consuming, (iii) often inaccurate, incomplete, prone errors.In this paper we present SEEG Assistant, a set tools...
Glioneuronal tumours are an important cause of treatment-resistant epilepsy. Subtypes tumour often poorly discriminated by histological features and may be difficult to diagnose due a lack robust diagnostic tools. This is illustrated marked variability in the reported frequencies across different epilepsy surgical series. To address this, we used DNA methylation arrays RNA sequencing assay expression profiles within large cohort glioneuronal tumours. By adopting class discovery approach,...
To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015.We collected information on volumes types surgery, pathology, seizure outcome from 20 recognized reference centers 10 countries.We analyzed retrospective aggregate data 1859 operations. The proportion surgeries significantly increased over time (P < .0001). Engel class I was achieved 69.3% children, with no significant improvement 2015. histopathological findings consistent glial scars the ages...
OBJECTIVE The aim of this study was to compare the accuracy optical frameless neuronavigation (ON) and robot-assisted (RA) stereoelectroencephalography (SEEG) electrode placement in children, identify factors that might increase risk misplacement. METHODS authors undertook a retrospective review all children who underwent SEEG at their institution. Twenty were identified stereotactic total 218 electrodes. Six procedures performed using ON 14 placed robotic assistant. Placement error...
We aimed to assess determinants of seizure outcome following pediatric hemispherotomy in a contemporary cohort.We retrospectively analyzed the outcomes 457 children who underwent hemispheric surgery five European epilepsy centers between 2000 and 2016. identified variables related through multivariable regression modeling with missing data imputation optimal group matching, we further investigated role surgical technique by Bayes factor (BF) analysis.One hundred seventy seven (39%) vertical...
BACKGROUND: A variety of near-infrared spectroscopy devices can be used to make noninvasive measurements cerebral tissue oxygen saturation (ScO2). The ScO2 measured by the NIRO 300 spectrometer (Hamamatsu Photonics, Japan) is called oxygenation index (TOI) and an assessment balance between delivery utilization. We designed this study investigate effect systemic intracranial physiological changes on TOI. METHODS: Fifteen healthy volunteers were studied during isocapneic hyperoxia hypoxemia,...
Glioneuronal tumors (GNTs) are well-recognized causes of chronic drug-resistant focal epilepsy in children. Our practice involves an initial period radiological surveillance and antiepileptic medications, with surgery being reserved for those progression or refractory seizures. We planned to analyze the group patients low-grade GNTs, aiming identify factors affecting seizure cognitive outcomes.We retrospectively reviewed medical records 150 children presenting Great Ormond Street Hospital...
Summary Objective Drug‐resistant epilepsy (DRE) during the first few months of life is challenging and necessitates aggressive treatment, including surgery. Because most common causes DRE in infancy are related to extensive developmental anomalies, surgery often entails tissue resections or disconnection. The literature on “ultra‐early” sparse, with limited data concerning efficacy controlling seizures, safety. current study's goal review safety ultra‐early performed before age 3 months....