A5009629552- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Craniofacial Disorders and Treatments
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- EEG and Brain-Computer Interfaces
- Teratomas and Epidermoid Cysts
- Cleft Lip and Palate Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Oral and Maxillofacial Pathology
- Infectious Encephalopathies and Encephalitis
- Sleep and Wakefulness Research
- Spinal Fractures and Fixation Techniques
Sapienza University of Rome
2025
Istituto Giannina Gaslini
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Vita-Salute San Raffaele University
2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
Children's Hospital
2021
Bambino Gesù Children's Hospital
2021
University of Genoa
2019
Azienda Ospedaliero-Universitaria Careggi
2018
Boston Children's Hospital
2009-2010
Sturge-Weber Syndrome (SWS) is a rare, sporadic neurocutaneous disorder affecting the skin, brain, and eyes, due to somatic activating mutations in GNAQ or, less commonly, GNA11 gene. It characterized by at least two of following features: facial capillary malformation, leptomeningeal vascular ocular involvement. The spectrum clinical manifestations includes headache, seizures, stroke-like events, intellectual disability, glaucoma, asymmetry, gingival hyperplasia, etc. An early diagnosis...
OBJECTIVE Cranioplasty is a reconstructive procedure used to restore skull anatomy and repair defects. Optimal reconstruction challenge for neurosurgeons, the strategy achieve best result remains topic of debate, especially in pediatric patients whom continuing growth makes choice material more difficult. When native bone flap, which universally accepted as preferred option patients, unavailable, authors' prosthetic polymethylmethacrylate (PMMA) implant designed using custom-made technique....
To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015.We collected information on volumes types surgery, pathology, seizure outcome from 20 recognized reference centers 10 countries.We analyzed retrospective aggregate data 1859 operations. The proportion surgeries significantly increased over time (P < .0001). Engel class I was achieved 69.3% children, with no significant improvement 2015. histopathological findings consistent glial scars the ages...
To assess seizure and cognitive outcomes their predictors in children (<16 years at surgery) adults undergoing temporal lobe epilepsy (TLE) surgery eight Italian centers.This is a retrospective multicenter study. We performed descriptive analysis subsequently carried out multivariable mixed-effect models corrected for multiple comparisons.We analyzed data from 511 patients (114 children) observed significant differences several clinical features between children. The possibility of achieving...
Summary Objective To analyze the attitude and results of Italian epilepsy surgery centers in surgical management “low grade associated neuroepithelial tumors” ( LEAT s). Methods We conducted a retrospective study enrolling 339 consecutive patients with s who underwent between January 2009 June 2015 at eight centers. compared demographic, clinical, pathologic, features favorable (Engel class I) unfavorable II , III, IV ) seizure outcome. In addition, we tumor‐associated focal cortical...
Summary Objective Drug‐resistant epilepsy (DRE) during the first few months of life is challenging and necessitates aggressive treatment, including surgery. Because most common causes DRE in infancy are related to extensive developmental anomalies, surgery often entails tissue resections or disconnection. The literature on “ultra‐early” sparse, with limited data concerning efficacy controlling seizures, safety. current study's goal review safety ultra‐early performed before age 3 months....
OBJECTIVE AND IMPORTANCE: Extraventricular ependymomas account for 50% of supratentorial ependymomas. Some tumors may extend to the gray matter reaching pial surface, but pure cortical are uncommon. Here, we report three patients with intracortical ependymoma. CLINICAL PRESENTATION: We reviewed clinicopathological findings all operated on at Bellaria Hospital during an 11-year period and found lesions described as The represented 2.5% ependymal 21.4% study period. patient were aged 52, 24,...
Neural tube defects are severe malformations affecting 1/1,000 live births. The planar cell polarity pathway controls the neural closure and has been implicated in pathogenesis of both animal models human cohorts. In mouse disruption Dvl2 alone (Dvl2 (-/-)) or Dvl3 (-/-); (+/-), (+/-); results incomplete neurulation, suggesting a role for Disheveled closure. is multifunctional protein that involved canonical Wnt signaling noncanonical pathway. this study, we analyzed orthologs DVL2 DVL3...
Abstract Objective To assess seizure and developmental outcomes, their predictors, complications in 160 children who, between 1998 2022, underwent surgery for lesional epilepsy with curative intent before the age of 3 years. compare trends this group after year 2014. Methods Retrospective multicenter study. Descriptive univariate analyses, multivariable models all outcomes. Results These patients (76 F; 47.5%) 169 surgeries (age at 20.4 ± 9.4 months). At last follow‐up (77 57.4 months), 121...
Background Neural Tube Defects (NTD) are a common class of birth defects that occur in approximately 1 1000 live births. Both genetic and nongenetic factors involved the etiology NTD. Planar cell polarity (PCP) genes plays critical role neural tube closure model organisms. Studies humans have identified nonsynonymous mutations PCP pathway genes, including VANGL may play as risk for Methods Here, we present results VANGL1 VANGL2 mutational screening series 53 NTD patients 27 couples with...