A5024710760- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Sleep and related disorders
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Head and Neck Surgical Oncology
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Cerebrospinal fluid and hydrocephalus
- Metabolism and Genetic Disorders
- Advanced Neuroimaging Techniques and Applications
- Ion channel regulation and function
- Neurobiology of Language and Bilingualism
- Infectious Encephalopathies and Encephalitis
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- Brain Tumor Detection and Classification
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016-2025
Collaborative Group (United States)
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Ospedale Policlinico San Martino
2023
Universitätsklinikum Erlangen
2022
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Ospedale Maggiore
2009-2010
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2006-2009
Santa Maria Nuova Hospital
2006-2009
Study Objectives:Arousal parasomnias are expressions of sleep/ wake state dissociations in which wakefulness and NREM sleep seem to coexist. We describe the results a neurophysiological (intracerebral EEG) investigation that captured an episode confusional arousal.
Sleep-related complex motor seizures are a common feature of nocturnal frontal lobe epilepsy. Nevertheless, recent studies also suggest that sleep-related hypermotor can originate in the insula. The present study describes electroclinical features eight drug-resistant epileptic patients with insular-opercular manifesting seizures.Patients underwent comprehensive presurgical evaluation, which included history, interictal electroencephalography (EEG), scalp video-EEG monitoring,...
Magnetic resonance imaging-positive temporal lobe atrophy with temporo-polar grey/white matter abnormalities (usually called 'blurring') has been frequently reported in patients epilepsy associated hippocampal sclerosis. The poor distinction of grey and white attributed to various causes, including developmental cortical abnormalities, gliosis, myelin alterations, a non-specific increase water content metabolic/perfusion alterations. However, there is still no consensus regarding the genesis...
Of the cases with nocturnal frontal lobe epilepsy (NFLE) approximately 30% are refractory to antiepileptic medication, several patients suffering from effects of both ongoing seizures and disrupted sleep. From a consecutive series 522 operated on for drug-resistant focal epilepsy, 21 (4%), whose occurred almost exclusively (>90%) during sleep, were selected. All underwent comprehensive pre-surgical evaluation, which included history, interictal EEG, scalp video-EEG monitoring,...
Summary Objective Hippocampal sclerosis ( HS ) is the major structural brain lesion in patients with temporal lobe epilepsy TLE ). However, its internal anatomic structure remains difficult to recognize at 1.5 or 3 Tesla T magnetic resonance imaging MRI ), which allows neither identification of specific pathology patterns nor their proposed value predict postsurgical outcome, cognitive impairment, underlying etiologies. We aimed identify subtypes resected surgical samples on 7 by...
In patients with temporal lobe epilepsy (TLE), assessment of language lateralization is important as anterior lobectomy may lead to impairments. Despite the widespread use fMRI, evidence its usefulness in predicting postsurgical performance scant. We investigated whether preoperative functional related performance, peri-ictal aphasia, and can predict outcome one year post-surgery. studied a total 72 TLE (42 left, 30 right), by using three fMRI tasks: Naming, Verb Generation Fluency....
In the present report, correlations between ex vivo high-resolution imaging and specific histological ultrastructural patterns in type II focal cortical dysplasia (FCD) have been studied to explain differences magnetic resonance (MRI) detection of contribute presurgical evaluation this pathology.Surgical specimens from 13 patients with FCD IIa/b were submitted 7T MRI scanning, then analyzed histologically ultrastructurally compare results findings. Region interest (ROI)-based measures on...
To assess seizure and cognitive outcomes their predictors in children (<16 years at surgery) adults undergoing temporal lobe epilepsy (TLE) surgery eight Italian centers.This is a retrospective multicenter study. We performed descriptive analysis subsequently carried out multivariable mixed-effect models corrected for multiple comparisons.We analyzed data from 511 patients (114 children) observed significant differences several clinical features between children. The possibility of achieving...
In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed a naturalistic setting are useful complement to characterize the drug profile. This multicentre study assessed effectiveness and tolerability of adjunctive BRV large population epilepsy context real-world clinical practice. The BRIVAFIRST (BRIVAracetam First Italian netwoRk STudy) was retrospective, including adult prescribed BRV. Patients...
Summary Purpose: To analyze the topography of epileptogenic zone (EZ) and etiologic substrate as risk factors for sleep‐related focal epilepsy. Methods: Three hundred three patients (172 males 131 females, mean age at surgery 25.6 ± 13.1 years), who were seizure‐free after resective drug‐resistant epilepsy, retrospectively reviewed. Statistical analysis was conducted to evaluate presenting epilepsy (SRE) against resection (assumed correspond or include EZ) results histology. Results:...
Comprehensively describe the phenotypic spectrum of sporadic fatal insomnia (sFI) to facilitate diagnosis and management this rare peculiar prion disorder.A survey among major disease reference centers in Europe identified 13 patients diagnosed with sFI past 20 years. We undertook a detailed analysis clinical histopathological features results diagnostic investigations.Mean age at onset was 43 years, mean duration 30 months. Early findings included psychiatric, sleep, oculomotor...
Objective The contribution of recurring seizures to the progression epileptogenesis is debated. Seizure‐induced brain damage not conclusively demonstrated either in humans or animal models epilepsy. We evaluated expression injury biomarkers on postsurgical tissue obtained from 20 patients with frequent and a long history drug‐resistant focal Methods patterns specific glial, neuronal, inflammatory molecules were by immunohistochemistry core type II cortical dysplasias (FCD‐II), at FCD...
Summary Objective To analyze the attitude and results of Italian epilepsy surgery centers in surgical management “low grade associated neuroepithelial tumors” ( LEAT s). Methods We conducted a retrospective study enrolling 339 consecutive patients with s who underwent between January 2009 June 2015 at eight centers. compared demographic, clinical, pathologic, features favorable (Engel class I) unfavorable II , III, IV ) seizure outcome. In addition, we tumor‐associated focal cortical...
Abstract Objective Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought determine benchmark outcomes in patients after surgery drug‐resistant mesial temporal lobe epilepsy (MTLE). Methods This retrospective multicenter study included who underwent MTLE at 19 expert centers on five continents. Benchmarks were defined 15 endpoints covering outcome discharge, 1 year surgery, last available follow‐up....
Abstract Musicogenic epilepsy (ME) is characterized by seizures triggered music. The epileptogenic focus in this rare reflex often the temporal lobe, although precise localization still unclear. A correlation between ME and presence of GAD65 antibodies indicates a potential immunological pathogenic mechanism. We evaluated 32‐year‐old woman with drug‐resistant lobe as candidate for surgery. In absence clear clinical lateralizing signs, video‐EEG monitoring intracranial electrodes inserted...
Subjects with intellectual disability are usually excluded from clinical trials and there is limited evidence-based guidance for the choice of antiseizure medications in this vulnerable population. The study explored effectiveness brivaracetam (BRV) people epilepsy disability. BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST) was a 12-month retrospective, multicenter including adults prescribed adjunctive BRV. Main outcomes included rates seizure‐freedom, seizure response (≥ 50%...
The maintenance of seizure control over time is a clinical priority in patients with epilepsy. aim this study was to assess the sustained frequency reduction adjunctive brivaracetam (BRV) real-world practice. Patients focal epilepsy prescribed add-on BRV were identified. Study outcomes included freedom and response, defined as 100% ≥50% baseline that continued without interruption withdrawal through 12-month follow-up. Nine hundred ninety-four median age 45 (interquartile range = 32-56)...
Summary Objective Because temporal lobe epilepsy ( TLE ) can impair theory of mind (ToM), we examined the effects anterior lobectomy ATL by comparing preoperative to postoperative ToM course with that other cognitive functions characteristically impaired in . Methods Eighty‐five patients left (n = 39) or right 46) drug‐resistant and an age at onset >12 54) ≤12 years 31) were evaluated before 1 year after surgery; 40 healthy controls assessed baseline. The participants' recognition...