A5074683378- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- GaN-based semiconductor devices and materials
- Fetal and Pediatric Neurological Disorders
- Advanced Memory and Neural Computing
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Anesthesia and Sedative Agents
- Memory and Neural Mechanisms
- Neurobiology of Language and Bilingualism
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Hearing Loss and Rehabilitation
- Photocathodes and Microchannel Plates
- Biomedical Text Mining and Ontologies
- Advanced Text Analysis Techniques
- Histiocytic Disorders and Treatments
Kempenhaeghe
2016-2025
Maastricht University Medical Centre
2015-2025
Centre Hospitalier Universitaire de Martinique
2023-2025
Maastricht University
2018-2025
Leipzig University
2023
Eindhoven University of Technology
2018-2023
Sandia National Laboratories
2023
Philips (Netherlands)
2023
Tampere University Hospital
2023
Hospital de Santa Maria
2023
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
The efficacy of deep brain stimulation the anterior nucleus thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated double-blind Stimulation Anterior Nucleus Thalamus for Epilepsy randomized controlled trial. Medtronic Registry (MORE) aims to understand safety and longer-term effectiveness ANT DBS therapy routine clinical practice.
Abstract Speech neuroprosthetics aim to provide a natural communication channel individuals who are unable speak due physical or neurological impairments. Real-time synthesis of acoustic speech directly from measured neural activity could enable conversations and notably improve quality life, particularly for have severely limited means communication. Recent advances in decoding approaches led high reconstructions invasively activity. However, most prior research utilizes data collected...
The diagnosis of frontal lobe epilepsy may be compounded by poor electroclinical localization, due to distributed or rapidly propagating epileptiform activity. This study aimed at developing optimal procedures for localizing interictal discharges (IEDs) patients with localization related in the lobe. To this end results obtained magnetoencephalography (MEG) and electroencephalography (EEG) were compared systematically using automated analysis procedures.Simultaneous recording EEG MEG was...
Deep brain stimulation of the anterior nucleus thalamus (ANT-DBS) can improve seizure control for patients with drug-resistant epilepsy (DRE). Yet, one cannot overlook high discrepancy in efficacy among patients, possibly resulting from differences site.To test hypothesis that at junction ANT and mammillothalamic tract (ANT-MTT junction) increases control.The relationship between location active contacts to ANT-MTT was investigated 20 treated ANT-DBS DRE. Coordinates Euclidean distance...
Stereoelectroencephalography (SEEG) is an established diagnostic technique for the localization of epileptogenic zone in drug-resistant epilepsy. In vivo accuracy SEEG electrode positioning paramount importance since higher may lead to more precise resective surgery, better seizure outcome and reduction complications.To describe experiences with our comprehensive epilepsy center, illustrate surgical methodology, evaluate application consider yield implantations.All patients who underwent...
Abstract Speech production is an intricate process involving a large number of muscles and cognitive processes. The neural processes underlying speech are not completely understood. As uniquely human ability, it can be investigated in animal models. High-fidelity data only obtained clinical settings therefore easily available to all researchers. Here, we provide dataset 10 participants reading out individual words while measured intracranial EEG from total 1103 electrodes. data, with its...
Abstract Objective Short‐term outcomes of deep brain stimulation the anterior nucleus thalamus (ANT‐DBS) were reported for people with drug‐resistant focal epilepsy (PwE). Because long‐term data are still scarce, Medtronic Registry Epilepsy (MORE) evaluated clinical routine application ANT‐DBS. Methods In this multicenter registry, PwE ANT‐DBS followed up safety, efficacy, and battery longevity. Follow‐up ended after 5 years or upon study closure. Clinical characteristics settings compared...
Abstract Objective Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought determine benchmark outcomes in patients after surgery drug‐resistant mesial temporal lobe epilepsy (MTLE). Methods This retrospective multicenter study included who underwent MTLE at 19 expert centers on five continents. Benchmarks were defined 15 endpoints covering outcome discharge, 1 year surgery, last available follow‐up....
In resective epilepsy surgery for drug-resistant focal (DRE), good seizure outcome is strongly associated with visualization of an epileptogenic lesion on MRI. Standard clinical MRI (≤ 3 Tesla (T)) may fail to detect subtle lesions. 7T enhances detection and delineation, the potential benefits increasing field strength 9.4T are explored. A 36 years old male patient DRE evaluated surgery, in which 3T failed any lesions, was submitted a dedicated scan protocol using T1 T2* weighted imaging at...
Abstract Objective To investigate whether local lesions created by stereo‐electroencephalography (SEEG)–guided radiofrequency thermocoagulation (RFTC) affect distant brain connectivity and excitability in patients with focal, drug‐resistant epilepsy (DRE). Methods Ten focal DRE underwent SEEG implantation subsequently 1 Hz bipolar repetitive electrical stimulation (RES) for 30 s before after RFTC. Root mean square (RMS) of cortico‐cortical evoked potentials (CCEPs) was calculated 15 ms to...
At present, in epilepsy, magnetoencephalography (MEG) is mostly used for presurgical evaluations. It has proven to be robust detecting and localizing interictal epileptiform discharges. Whether this also true first-line investigation the diagnosis of epilepsy not been investigated yet. We present our data on usefulness MEG earliest phase diagnosing epilepsy. examined 51 patients with suspicion neocortical an inconclusive routine EEG. A method integrate daily was developed. Results visually...
Deep brain stimulation (DBS) of the anterior nucleus thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning DBS lead potentially essential maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode can aid targeting ANT during surgery hypothesize that neuronal firing properties target region relate to clinical outcome. prospectively included 10 epilepsy performed under...
Aim of this study was to examine the relation between perception facial expressions and interpersonal behavior in epilepsy patients after unilateral amygdalohippocampectomy (AH). Nine with 14 controls completed a forced-choice emotional recognition task, which morphed were shown at different intensities, self-report questionnaire behavior. Face depressive symptoms also taken into account. Compared normal controls, less sensitive fearful disgusted expressions, line previous reports. These...