A5050543396- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Chronic Disease Management Strategies
- Genomics and Rare Diseases
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Face Recognition and Perception
- EEG and Brain-Computer Interfaces
- Genetic factors in colorectal cancer
- Fetal and Pediatric Neurological Disorders
- Autism Spectrum Disorder Research
- Healthcare cost, quality, practices
- Hallucinations in medical conditions
- Virology and Viral Diseases
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Immune responses and vaccinations
- Migraine and Headache Studies
- Facial Nerve Paralysis Treatment and Research
- Hair Growth and Disorders
- Bipolar Disorder and Treatment
- Parallel Computing and Optimization Techniques
- Skin and Cellular Biology Research
Assistance Publique – Hôpitaux de Paris
2021-2023
Circuit Therapeutics (United States)
2023
Brigham and Women's Hospital
2023
Harvard University
2019-2023
Boston Children's Hospital
2020-2023
Banque Nationale de Gènes
2022
Weatherford College
2022
Institut des Maladies Génétiques Imagine
2022
Berenson Allen Center for Noninvasive Brain Stimulation
2019-2021
Beth Israel Deaconess Medical Center
2019-2021
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized cervical dystonia, but therapeutic success compromised by non-responder rate up to 25%, even in carefully-selected groups. Variability electrode placement inappropriate settings may account large proportion this outcome variability. Here, we present probabilistic mapping data on cohort patients collected from several European centres resolve optimal volume within...
Face blindness can occur after injury to a variety of brain locations, and yet the regions critical for face recognition remain unclear. Cohen et al. show that lesions cause map specific network, use this predict subclinical deficits in an independent lesion cohort.
Abstract Inconsistent findings from migraine neuroimaging studies have limited attempts to localize symptomatology. Novel brain network mapping techniques offer a new approach for linking common neuroanatomical substrate and localizing therapeutic targets. In this study, we attempted determine whether neuroanatomically heterogeneous of network. We used meta-analytic coordinates decreased grey matter volume in migraineurs as seed regions generate resting state functional connectivity maps...
Abstract Dementia is a common and devastating symptom of Parkinson’s disease but the anatomical substrate remains unclear. Some evidence points towards hippocampal involvement neuroimaging abnormalities have been reported throughout brain are largely inconsistent across studies. Here, we test whether these disparate findings for dementia localize to network. We used literature search identify studies reporting correlates (11 studies, 385 patients). restricted our atrophy hypometabolism that...
Objective Approximately 50% of patients with tuberous sclerosis complex develop infantile spasms, a sudden onset epilepsy syndrome associated poor neurological outcomes. An increased burden tubers confers an elevated risk but it remains unknown whether some tuber locations confer higher than others. Here, we test location and connectivity are spasms. Methods We segmented from 123 children (n = 74) without 49) spasms prospective observational cohort. used voxelwise lesion symptom mapping to...
BACKGROUND. Although mania is characteristic of bipolar disorder, it can also occur following focal brain damage. Such cases may provide unique insight into regions responsible for symptoms and identify therapeutic targets.
Objectives: The relevant neuroanatomy for gait dysfunction remains unclear. We sought 1) to identify a brain circuit impairment post stroke, 2) changes after subthalamic DBS Parkinson′s disease, 3) test convergence between these two circuits. Methods: This cross-sectional retrospective study used data from four independent datasets including 109 individuals with stroke and 125 patients PD who received DBS. Gait was measured using the Combined Walking Index. subscore on UPDRS Part III....
Abstract Background Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for individuals with chronic diseases. However, few are available rare and undiagnosed diseases (RUDs). We aimed assess the impact of on activities French reference network RUDs in 2020. Results In this longitudinal retrospective study, we extracted analyzed national registry collected between Jan 1, 2019 Dec 31, compared annual evolution 2020 focusing adult pediatric...
Abstract Background In France, the Ministry of Health has implemented a comprehensive program for rare diseases (RD) that includes an epidemiological as well establishment expert centers clinical care patients with RD. Since 2007, most these have entered data developmental disorders into CEMARA population-based registry, national online repository all diseases. Through web portal, descriptive demographic data, and chronology medical follow-up can be obtained each center. We address interest...
<h3>Objective:</h3> To test whether lesions related to epilepsy map a common brain network. <h3>Background:</h3> Focal is commonly caused by lesions, but it remains unclear why some lesion locations result in while others do not. One possibility that regions or networks are more vulnerable than others. Identifying the could inform prognosis and guide interventions. <h3>Design/Methods:</h3> Lesion from patients with ischemic stroke-related (n = 76) control 625) were mapped atlas. Traditional...
Background: Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for individuals with chronic diseases. However, few are reported rare and undiagnosed diseases (RUDs). We aimed assess the impact of on activities French reference network RUDs in 2020.Methods: In this observational, cross-sectional study, we extracted analyzed national registry collected between Jan 1, 2019 Dec 31, 2020. compared annual longitudinal evolution 2020 focusing...
Abstract Background: Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for individuals with chronic diseases. However, few are reported rare and undiagnosed diseases (RUDs). We aimed assess the impact of on activities French reference network RUDs in 2020.Results: In this observational, cross-sectional study, we extracted analyzed national registry collected between Jan 1, 2019 Dec 31, 2020. compared annual longitudinal evolution 2020...
To evaluate whether stroke lesion locations disrupting gait and deep brain stimulation (DBS) sites improving in Parkinson's disease (PD) map to a common circuit.