A5090905836- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Neurological diseases and metabolism
- COVID-19 and Mental Health
- Restless Legs Syndrome Research
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- Biochemical Analysis and Sensing Techniques
- Balance, Gait, and Falls Prevention
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Sleep and Wakefulness Research
- Voice and Speech Disorders
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Ginkgo biloba and Cashew Applications
- Advanced Chemical Sensor Technologies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mitochondrial Function and Pathology
Innsbruck Medical University
2016-2025
Universität Innsbruck
2015-2025
University College London
2014-2024
National Hospital for Neurology and Neurosurgery
2015-2024
John Wiley & Sons (United States)
2020-2023
Centro de Investigación Biomédica en Red
2015-2017
Hospital Clínic de Barcelona
2017
Sobell House
2014-2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, potentially intervene neuroprotective therapy. For future trials, it essential accurately estimate phenoconversion rate identify potential predictors phenoconversion. study assessed the disease risk neurodegeneration in large multicentre cohort...
Background Although gait disorders are common in the elderly, prevalence and overall burden of these general community is not well defined. Methods In a cross-sectional investigation population-based Bruneck Study cohort, 488 community-residing elderly aged 60–97 years underwent thorough neurological assessment including standardized evaluation. Gait were classified according to an accepted scheme their associations falls, neuropsychological measures, quality life explored. Results Overall,...
The ventral intermediate nucleus (VIM) of the thalamus is an established surgical target for stereotactic ablation and deep brain stimulation (DBS) in treatment tremor Parkinson's disease (PD) essential (ET). It centrally placed on a cerebello-thalamo-cortical network connecting primary motor cortex, to dentate contralateral cerebellum through dentato-rubro-thalamic tract (DRT). VIM not readily visible conventional MR imaging, so identifying traditionally involved indirect targeting that...
To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19.In this prospective, multicenter, observational cohort study we systematically evaluated signs diseases by detailed examination a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assessment), QoL (36-item Short Form), mental health (Hospital Anxiety Depression Scale, Posttraumatic Stress Disorder Checklist-5) disease...
Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery acute infection. Here, the aim was to describe natural history of neurological manifestations over 1 year COVID-19.A prospective, multicentre, longitudinal cohort study in COVID-19 survivors performed. At a 3-month and 1-year follow-up, patients were assessed for impairments by examination standardized test battery including assessment hyposmia (16-item Sniffin' Sticks test), cognitive deficits...
The aim of the present study was to determine predictive value olfactory dysfunction for early development a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observational period 5 years.Thirty-four patients polysomnography-confirmed iRBD underwent testing using entire Sniffin' Sticks test assessing odor identification, discrimination, and threshold. Patients were prospectively followed up 4.9 ± 0.3 years (mean SD). diagnosis...
<h3>Objective</h3>To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population.<h3>Design</h3>Longitudinal 3-center observational study 37 months of prospective follow-up.<h3>Setting</h3>Individuals 50 years or older without evidence PD any other neurodegenerative disease.<h3>Participants</h3>Of 1847 participants who underwent full medical history, neurological assessment, and...
ABSTRACT Background Dorsolateral nigral hyperintensity on iron‐sensitive magnetic resonance imaging (MRI) sequences seems to be a typical finding in Parkinson's disease (PD), but most studies have involved small samples and had heterogeneous control populations. Objectives The objective of this study was perform meta‐analysis dorsolateral as an marker for PD. Methods methods included systematic literature search hierarchical summary receiver operating characteristics curve approach. Results...
Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized cervical dystonia, but therapeutic success compromised by non-responder rate up to 25%, even in carefully-selected groups. Variability electrode placement inappropriate settings may account large proportion this outcome variability. Here, we present probabilistic mapping data on cohort patients collected from several European centres resolve optimal volume within...
SN hyperechogenicity (SN+), determined by transcranial sonography, has been proposed as a risk factor for Parkinson's disease (PD). Recently, we reported 17.4-fold increased PD in individuals with SN+ older than 50 years within 3 years.This is the second follow-up of prospective, longitudinal, three-center observational study after 5 years. Of initial 1,847 at baseline PD-free participants or older, 1,271 underwent 5-year reassessment.Within years, 21 developed incident PD. Participants had...
Background and purpose Screening batteries to narrow down a target‐at‐risk population are essential for trials testing neuroprotective compounds aiming delay or prevent onset of P arkinson's disease ( PD ). Methods The PRIPS study focuses on early detection incident in 1847 at baseline ‐free subjects, assessed age, male gender, positive family history, hyposmia, subtle motor impairment enlarged substantia nigra hyperechogenicity SN +). Results After 3 years follow‐up 11 subjects had...
The prevalence of rapid eye movement sleep behavior disorder (RBD) and its association with markers neurodegeneration in the general population are poorly defined.We assessed probable RBD defined by two validated questionnaires, Screening Questionnaire (RBDSQ) Innsbruck RBD-Inventory (RBD-I), studied associations clinical imaging for Bruneck Study cohort aged 60 y or older.Of 456 participants without Parkinson's disease, 4.6% (RBDSQ; 95%CI, 3.0%-7.0%) 7.7% (RBD-I; 5.6%-10.5%) had RBD....
<b><i>Background:</i></b> Sarcopenia and frailty are found in up to one-third of the general elderly population. Both associated with major adverse health outcomes such as nursing home placement, disability, decreased quality life, death. Data on frequency both syndromes Parkinson’s disease (PD), however, very limited.<b><i> Objective:</i></b> We aimed screen for sarcopenia PD patients assess potential associations geriatric demographic...
Dystonia is a debilitating disease with few treatment options. One effective option deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted common approach posterior third nucleus, large-scale investigations regarding optimal sites potential network effects not carried out. Here, we retrospectively studied clinical results following DBS for in multicenter cohort 80 patients. We model electrode placement based on pre-...
To evaluate the presence of prodromal markers Parkinson disease (PD) in patients with longstanding idiopathic REM sleep behavior disorder (IRBD), a small subgroup individuals IRBD long-term follow-up thought not to be at risk developing PD.Demographic, clinical, and neuroimaging PD were evaluated 20 polysomnographic-confirmed 32 matched controls.Patients 16 men 4 women mean age 72.9 ± 8.6 years from diagnosis 12.1 2.6 years. Patients more often had objective smell loss (35% vs 3.4%, p =...
Study Objectives: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases.It unknown if this also applies to isolated REM without atonia (RWA).We performed long-term follow-up investigation subjects with RWA.Methods: Participants were recruited from 50 RWA who identifi ed at the laboratory Department Neurology Medical University Innsbruck between 2003 and 2005.Eligible underwent clinical examination, polysomnography,...
IntroductionPallidal deep brain stimulation (GPi-DBS) is an effective therapy for isolated dystonia, but 10–20% of patients show improvement below 25–30%. We here investigated causes insufficient response to GPi-DBS in dystonia a cross-sectional study.MethodsPatients with at time surgery, and <30% on the Burke-Fahn-Marsden dystonia-rating-scale (BFMDRS) after ≥6 months continuous were videotaped ON OFF stimulation, history, preoperative videos, MRI, medical records, settings, system...