A5079276029- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Dysphagia Assessment and Management
- Glycogen Storage Diseases and Myoclonus
- Child Nutrition and Feeding Issues
- Respiratory Support and Mechanisms
- Youth Substance Use and School Attendance
- Genetic Neurodegenerative Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Nicotinic Acetylcholine Receptors Study
- Psychosomatic Disorders and Their Treatments
- Sexual function and dysfunction studies
- Cardiovascular and Diving-Related Complications
- Genetics and Neurodevelopmental Disorders
Vita-Salute San Raffaele University
2015-2024
IRCCS Ospedale San Raffaele
2011-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2024
Neuroscience Institute
2017
San Raffaele University of Rome
1996-2016
University of Bologna
1983-2016
Great Ormond Street Hospital for Children NHS Foundation Trust
2016
University College London
2016
University of California San Diego Medical Center
2016
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, potentially intervene neuroprotective therapy. For future trials, it essential accurately estimate phenoconversion rate identify potential predictors phenoconversion. study assessed the disease risk neurodegeneration in large multicentre cohort...
The thalamus is affected in diffuse degenerative processes of the nervous system.1 2 3 4 5 However, it has not been established whether a genetically determined disease may be limited to selected thalamic nuclei.We report here case 53-year-old man who presented with progressive insomnia and dysautonomia (pyrexia, diaphoresis, miosis, sphincter disturbances). Dreamlike status, dysarthria, tremor, myoclonus subsequently developed led coma death after nine months.6 Two sisters patient many...
Abstract In a multinational, double‐blind, placebo‐controlled trial (NCT00474058), 287 subjects with Parkinson's disease (PD) and unsatisfactory early‐morning motor symptom control were randomized 2:1 to receive rotigotine (2–16 mg/24 hr [n = 190]) or placebo (n 97). Treatment was titrated optimal dose over 1–8 weeks subsequent maintenance for 4 weeks. Early‐morning function nocturnal sleep disturbance assessed as coprimary efficacy endpoints using the Unified Disease Rating Scale (UPDRS)...
Objective To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). Methods Twelve centers administered a detailed questionnaire assessing synucleinopathy to patients RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, autonomic/motor symptoms. After 4 years...
Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible desire to move the extremities associated with paraesthesia/dysaesthesia. These symptoms occur predominantly at rest and worsen night, resulting in nocturnal insomnia chronic sleep deprivation. In this paper, we show significant evidence of linkage new locus for RLS on chromosome 14q13-21 region 30-member, three-generation Italian family affected periodic leg movements (PLMS). This second...
To evaluate the cognitive performance of patients with idiopathic REM sleep behavior disorder (RBD).The authors studied 17 consecutive RBD vs age- and education-matched control subjects. Tests given to each patient included Mini-Mental State Examination, verbal spatial short-term memory, visual selective attention, fluency, prose visuoconstructional abilities, learning, executive function tests. A self-administered depression rating scale was also used.RBD had significantly lower scores than...
Summary The aim of this study was to evaluate quantitatively the amplitude submentalis muscle EMG activity during sleep in controls and patients with idiopathic REM behavior disorder (RBD) or RBD multiple system atrophy (MSA). We recruited 21 RBD, 10 MSA, age‐matched 24 young normal controls. average rectified signal used for assessment atonia a Sleep Atonia Index developed; moreover, also chin activations were detected their duration interval analyzed. able distinguish clearly from NREM...
Recent evidence has been accumulating that the sleep of individuals with attention deficit hyperactivity disorder (ADHD) is not only disrupted in a nonspecific way but ADHD an increased association simple related movement disorders such as restless legs syndrome/periodic limb movements (RLS/PLMS), rhythmic (body rocking and head banging), parasomnias, partial arousal (sleep walking, terrors, confusional arousals). In addition associations have reported between hypersomnias narcolepsy apnea...
The aims of this study were to measure the error in sleep estimation normal controls and subjects with primary insomnia establish minimum amount needed for reliable subjective depict distribution both groups. A two-step retrospective (study 1) prospective 2) validation was carried out. Study 1 included 288 [176 females 112 males, mean age 58.5 years, standard deviation (SD) 7.23]. 2 159 patients (98 61 males; 49.1 SD 12.71) insomnia. Participants underwent a full-night polysomnographic...
The purpose of this study was to characterize the nature relation between periodic leg movements during sleep (PLMS) and cortical arousals contribute debate on clinical significance treatment PLMS.A prospective, placebo-controlled, single-blind, parallel group carried out including 46 drug-naive patients with idiopathic restless legs syndrome (RLS). Each patient underwent 2 consecutive full-night polysomnographic studies. first night baseline night. Prior second night, 1 received a single...
Restless legs syndrome (RLS) is a neurological disorder with lifetime prevalence of 3-10%. in European studies. However, the diagnosis RLS primary care remains low and mistreatment common. The current article reports on considerations management that were made during Legs Syndrome Study Group (EURLSSG)-sponsored task force consisting experts practioners. sought to develop better understanding barriers practice overcome these diagnostic treatment algorithms. identified by include presentation...
<h3>Objective:</h3> Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and commonly prediagnostic sign of parkinsonism dementia. Since risk factors have not been defined, we initiated multicenter case-control study to assess environmental lifestyle for disorder. <h3>Methods:</h3> Cases were patients with idiopathic who free dementia parkinsonism, recruited from 13 International Sleep Behavior Disorder Study Group centers. Controls matched according age...
This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort.Data of self-administered questionnaire on use 318 iRBD matched controls were analyzed. Comparisons cases made logistic regression analysis.Patients more likely to report depression (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.3-2.9) concomitant antidepressant (OR...
Objective This study was undertaken to follow up predictive factors for α‐synuclein–related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD). Methods Patients with iRBD from 12 centers underwent detailed assessment potential environmental and lifestyle risk via standardized questionnaire at baseline. were then prospectively followed received assessments parkinsonism or dementia during follow‐up. The cumulative...