A5005301373- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Lysosomal Storage Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Biochemical Analysis and Sensing Techniques
- Carbohydrate Chemistry and Synthesis
- Genetics and Neurodevelopmental Disorders
- Innovative concrete reinforcement materials
- Child Nutrition and Feeding Issues
- Neurological disorders and treatments
- Sepsis Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Thyroid Disorders and Treatments
- Neurological and metabolic disorders
- Trypanosoma species research and implications
- Concrete and Cement Materials Research
- Dysphagia Assessment and Management
- High Altitude and Hypoxia
- Long-Term Effects of COVID-19
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
Universität Innsbruck
2021-2025
Innsbruck Medical University
2021-2025
Ahmadu Bello University
2023
23andMe (United States)
2022
Riyadh Armed Forces Hospital
2013
Abstract The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is powerful early predictor eventual phenoconversion, therefore represents critical opportunity to intervene neuroprotective therapy. To inform the design randomized trials, it essential study natural progression...
Objective This study was undertaken to follow up predictive factors for α‐synuclein–related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD). Methods Patients with iRBD from 12 centers underwent detailed assessment potential environmental and lifestyle risk via standardized questionnaire at baseline. were then prospectively followed received assessments parkinsonism or dementia during follow‐up. The cumulative...
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom alpha-synucleinopathies and defines a more severe subtype. The genetic background RBD its underlying mechanisms are not well understood. Here, we perform genome-wide association study RBD, identifying five risk loci near SNCA, GBA, TMEM175, INPP5F, SCARB2. Expression analyses highlight SNCA-AS1 potentially SCARB2 differential expression in different brain regions with...
Recently, it has become increasingly clear that there is a bidirectional relationship between sleep/circadian rhythms and neurodegeneration. Knowledge about this topic further improved after the description of glymphatic system, which mainly active during sleep. Changes in sleep circadian are present not only overt neurodegenerative diseases but also their early, prodromal, preclinical phases, supporting they precede (and contribute to) development This narrative review provides brief...
The objective of this study was to evaluate interrater reliability between manual sleep stage scoring performed in 2 European centers and automatic by the previously validated artificial intelligence-based Stanford-STAGES algorithm.Full night polysomnographies 1,066 participants were included. Sleep stages manually scored Berlin Innsbruck automatically with algorithm. For each participant, we compared (1) scorings (INN vs BER); (2) AUTO); (3) (BER (4) epochs where scorers from had consensus...
Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is critical due to its link α-synucleinopathies and risk injuries requires video-polysomnography (V-PSG). Usefulness screening questionnaires outside the context validation studies limited.The aim was assess performance three validated RBD compared with gold-standard V-PSG.In this bicentric prospective study, 400 consecutive subjects referred a center for first time filled (RBD Screening Questionnaire, Single Question,...
Received: 15 January 2025 Accepted after revision: 24 March Manuscript online:26
To investigate the frequency and characteristics of large muscle group movements (LMMs) during sleep in healthy adults.LMMs were scored following International Restless Legs Syndrome Study Group criteria 100 participants aged 19-77 years. A LMM was defined as a temporally overlapping increase EMG activity and/or occurrence movement artifacts at least two channels. indices durations total time (TST), NREM REM sleep, association with arousals, awakenings, respiratory events calculated....
Abstract Differentiation of central disorders hypersomnolence (DOH) is challenging but important for patient care. This study aimed to investigate whether biomarkers derived from sleep structure evaluated both by manual scoring as well with artificial intelligence (AI) algorithms allow distinction patients different DOH. We included video-polysomnography data 40 narcolepsy type 1 (NT1), 26 2 (NT2), 23 idiopathic hypersomnia (IH) and 54 participants subjective excessive daytime sleepiness...
Automatic 3D video analysis of the lower body during rapid eye movement (REM) sleep has been recently proposed as a novel tool for identifying people with isolated REM behavior disorder (iRBD), but, so far, it not validated on unseen subjects. This study aims at validating this technology in large cohort and improving its performances by also including an movements head, hands upper body.
Hypoxia at high altitude facilitates changes in ventilatory control that can lead to nocturnal periodic breathing (nPB). Here, we introduce a placebo-controlled approach prevent nPB by increasing inspiratory CO
Summary Previous studies indicated that patients with isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) exhibit alterations in spectral electroencephalographic (EEG), spindle, and slow‐wave features. As it is currently unknown how these EEG features evolve over time, this study aimed to evaluate their temporal progression iRBD comparison controls. We included 23 Two polysomnographies (baseline follow‐up) were recorded a mean (standard deviation) interval of 4.0 (2.5) years...
Abstract Study Objectives Sleep is altered early in neurodegenerative diseases (NDDs) and may contribute to neurodegeneration. Long-term, large sample-size studies assessing NDDs association with objective sleep measures are scant. We aimed investigate whether video-polysomnography (v-PSG)-based features associated long-term incidence. Methods Retrospective cohort study of patients referred 2004–2007 the Disorders Unit, Neurology, Medical University Innsbruck, Austria. All ≥ 18 years...
Abstract Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen ( HLA ) locus plays a role in iRBD LBD. iRBD, HLA‐DRB1 *11:01 was only allele passing FDR correction (OR = 1.57, 95% CI 1.27–1.93, p 2.70e‐05). We also discovered associations between 70D 1.26, 95%CI 1.12–1.41, 8.76e‐05), 70Q 0.81, 0.72–0.91,...
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing fully-automated machine learning framework for the prediction phenoconversion in patients with iRBD by using data recorded during polysomnography (PSG). A total 66 were included, whom 18 converted to an overt alpha-synucleinopathy within 2.7 ± 1.0 years. For each patient, baseline PSG was available. Sleep stages scored automatically, and time...
Abstract Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematological cancers. It characterized by accumulation clonal cells, predominantly in the bone marrow. The prevalence type 2 diabetes increasing; therefore, it expected there will be an increase diagnosis multiple with concomitant mellitus. treatment and mellitus multifaceted. coexistence two conditions patient forms major challenge physicians.
ABSTRACT Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom alpha-synucleinopathies. RBD also defines more severe forms The genetic background and its underlying mechanisms are not well understood. Here, we performed the first genome-wide association study RBD, identifying five risk loci. Expression analyses highlight SNCA-AS1 SCARB2 differential expression in different brain regions with further supported by...