Daniella Coker
A5082634050- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Neurological diseases and metabolism
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Biochemical Analysis and Sensing Techniques
- Genetics and Neurodevelopmental Disorders
- Nonmelanoma Skin Cancer Studies
- Lysosomal Storage Disorders Research
- Genomic variations and chromosomal abnormalities
- Liver Disease Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Obesity, Physical Activity, Diet
- Neuroscience and Music Perception
- HIV/AIDS Research and Interventions
- Cell Adhesion Molecules Research
- Music and Audio Processing
- Cognitive Abilities and Testing
- Autism Spectrum Disorder Research
- Nutrition, Genetics, and Disease
- Animal Vocal Communication and Behavior
- Forensic and Genetic Research
- Hops Chemistry and Applications
- Homelessness and Social Issues
23andMe (United States)
2020-2024
University of Exeter
2023
Oak Ridge Institute for Science and Education
2022
Oak Ridge Associated Universities
2022
University of Rochester Medical Center
2022
Boston University
2022
Westchester Medical Center
2022
Columbia University
2022
Eli Lilly (United States)
2022
Valley Health System
2022
Abstract Reading and writing are crucial life skills but roughly one in ten children affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study 51,800 adults self-reporting diagnosis 1,087,070 controls identified 42 independent significant loci: 15 genes linked cognitive ability/educational attainment, 27 new potentially more specific...
Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies performed in just one population at a time. Here we large-scale multi-ancestry meta-analysis of with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals European, East Asian, Latin American African ancestry. In meta-analysis, 78 significant loci, 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2,...
Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency act prematurely and associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) eight impulsive personality traits from Barratt Impulsiveness Scale short UPPS-P Impulsive Personality ( N = 123,509–133,517 23andMe research participants European ancestry), measure Drug Experimentation 130,684). Because these GWAS...
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists substantial gap across populations. We propose MUSSEL, method for ancestry-specific polygenic prediction that borrows information in summary statistics from genome-wide association studies (GWASs) multiple ancestry groups via Bayesian hierarchical modeling ensemble learning. In our simulation data analyses four distinct studies, totaling 5.7 million...
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom alpha-synucleinopathies and defines a more severe subtype. The genetic background RBD its underlying mechanisms are not well understood. Here, we perform genome-wide association study RBD, identifying five risk loci near SNCA, GBA, TMEM175, INPP5F, SCARB2. Expression analyses highlight SNCA-AS1 potentially SCARB2 differential expression in different brain regions with...
Although many rare variants have been reportedly associated with Parkinson's disease (PD), not replicated or failed to replicate. Here, we conduct a large-scale replication of PD variants. We assessed total 27,590 cases, 6701 proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, AMP-PD. Based on well-known genes, 834 interest were selected the ClinVar annotated 23andMe dataset. performed meta-analysis using summary statistics all studies. The resulted in five...
Abstract The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s disease (PD); however, questions remain regarding penetrance, clinical phenotype and natural history carriers. We performed a 3.5-year prospective longitudinal online study in large number 1286 genotyped carriers 109 154 controls, with without PD, recruited from 23andMe Research Cohort. collected self-reported motor non-motor symptoms every 6 months, as well demographics, family histories environmental risk...
Abstract COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal others. Based on study over one million 23andMe research participants, we report genetic and non-genetic associations testing positive for COVID-19, respiratory symptoms, hospitalization. Risk factors hospitalization include advancing age, male sex, elevated body mass index, lower socio-economic status, non-European ancestry, pre-existing cardio-metabolic conditions. Using trans-ethnic...
Abstract There is currently a dearth of accessible whole genome sequencing (WGS) data for individuals residing in the Americas with Sub-Saharan African ancestry. We generated at intermediate (15×) coverage 2,294 large amounts ancestry, predominantly Atlantic admixed varying European and American performed extensive comparisons variant callers, phasing algorithms, filtration on these to construct high quality imputation panel containing from 2,269 unrelated individuals. With exception TOPMed...
Abstract Basal cell carcinoma and squamous are the most common skin cancers, have genetic overlap with melanoma, pigmentation traits, autoimmune diseases, blood biochemistry biomarkers. In this multi-trait analysis of over 300,000 participants from Europe, Australia United States, we reveal 78 risk loci for basal (19 previously unknown replicated) 69 (15 replicated). The implicated in cancer development progression (e.g. CDKL1 ), TPCN2 cardiometabolic FADS2 immune-regulatory pathways innate...
Few African Americans have been able to trace family lineages back ancestors who died before the 1870 United States Census, first in which all Black people were listed by name. We analyzed 27 individuals from Maryland’s Catoctin Furnace American Cemetery (1774–1850), identifying 41,799 genetic relatives among consenting research participants 23andMe, Inc.’s database. One of highest concentrations close is Maryland, suggesting that descendants remain area. find many derived ancestry Wolof or...
Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition that predisposes to emphysema, cirrhosis, panniculitis, and vasculitis. Underrecognition has prompted efforts enhance early detection testing of at-risk individuals. Direct-to-consumer (DTC) genetic represents additional method detection.
To further our understanding of the genetics musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGS
Alcohol consumption is associated with numerous negative social and health outcomes. These associations may be direct consequences of drinking, or they reflect common genetic factors that influence both alcohol other
Abstract Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading spelling. It substantially heritable frequently co-occurs other conditions, particularly attention deficit-hyperactivity disorder (ADHD). Here, we investigate the genetic structure underlying dyslexia range of psychiatric traits using results from genome-wide association studies dyslexia, ADHD, autism, anorexia nervosa, anxiety, bipolar disorder, major depressive...
Early detection of Parkinson's disease (PD), a neurodegenerative with central and peripheral nerve involvement, ensures timely treatment access. Microbes influence nervous system health are altered in PD. We examined gut mouth microbiomes from recently diagnosed patients geographically diverse, matched case-control, shotgun metagenomics study. Here, we show greater alpha-diversity 445 PD versus 221 controls. The microbial signature includes overabundance 16 OTUs, including Streptococcus...