A5057859445- Attention Deficit Hyperactivity Disorder
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Substance Abuse Treatment and Outcomes
- Functional Brain Connectivity Studies
- Suicide and Self-Harm Studies
- Health, Environment, Cognitive Aging
- Bipolar Disorder and Treatment
- Alcohol Consumption and Health Effects
- Cognitive Abilities and Testing
- Obesity, Physical Activity, Diet
- Coffee research and impacts
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Mental Health Research Topics
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Autism Spectrum Disorder Research
- Gastrointestinal motility and disorders
- Adolescent and Pediatric Healthcare
- Neurotransmitter Receptor Influence on Behavior
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Early Childhood Education and Development
Vall d'Hebron Institut de Recerca
2019-2025
Universitat Autònoma de Barcelona
2019-2025
University of California, San Diego
2025
Centro de Investigación Biomédica en Red de Salud Mental
2021-2024
Vall d'Hebron Hospital Universitari
2019-2024
Centre for Biomedical Network Research on Rare Diseases
2023-2024
Instituto de Salud Carlos III
2021-2023
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
Abstract Background Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of involvement remains unclear. Methods We used genomic structural equation modeling genome-wide association studies ( N = 79,729–903,147) to examine latent genetic architecture nine traits seven (SU) SUD traits. Results found that SU factors were strongly genetically inter-correlated r G =0.77) their associations...
Air pollution and greenness are emerging as modifiable risk protective factors, respectively, in child psychopathology. However, research shows inconsistencies. Here, we examined associations between air surrounding with internalizing externalizing behaviors. In addition, the potential modifying role of genetic susceptibility for these traits socioeconomic status (SES) was explored. This population-based study included 4485 schoolchildren aged 5-18 years from Spain. Internalizing behaviors...
Compelling evidence supports alterations in gut microbial diversity, bacterial composition, and/or relative abundance of several taxa attention-deficit/hyperactivity disorder (ADHD). However, findings for ADHD are inconsistent among studies, and specific microbiome signatures the remain unknown. Given that previous studies have mainly focused on pediatric form involved small sample sizes, we conducted largest study to date compare gastrointestinal composition 100 medication-naïve adults with...
Substance use disorder (SUD) often co-occur at high prevalence with other psychiatric conditions. Among them, attention-deficit and hyperactivity (ADHD) is present in almost one out of every four subjects SUD associated higher severity, more frequent polysubstance dependence increased risk for mental health problems patients. Despite studies suggesting a genetic basis the co-occurrence these two conditions, factors involved joint development both disorders mechanisms mediating causal...
Abstract Background Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental caused by combination of genetic and environmental factors often thought as an entry point into negative life trajectory, including risk for comorbid disorders, poor educational achievement or low income. In the present study, we aimed to clarify causal relationship between ADHD comprehensive range related traits. Methods We used genome-wide association study (GWAS) summary statistics...
Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability being partly determined genetic component, the underpinnings explaining high rates comorbidity remain largely unclear there are no conclusive data on temporal relationship between them. Exploring overlapping architecture IBS conditions may help to identify novel loci biological mechanisms...
Delay discounting (DD), a person's preference for smaller immediate rewards over larger delayed rewards, is heritable trait that associated with psychiatric and physical outcomes, yet the biological mechanisms underlying these links are not known. We performed GWAS of DD using 134,935 adults identified 14 genome-wide significant loci. observed genetic correlations between 73 behavioral, neuroimaging traits, many which persisted even after accounting educational attainment, intelligence,...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental that often persists into adulthood. There growing evidence epigenetic dysregulation participates in ADHD. Given only limited number of epigenome-wide association studies (EWASs) ADHD have been conducted so far and they mainly focused on pediatric population-based samples, we performed an EWAS clinical sample adults with We report one CpG site four regions differentially methylated between...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental that results from the interaction of both genetic and environmental risk factors. Genome-wide association studies have started to identify multiple loci associated with ADHD, however, exact causal genes biological mechanisms remain largely unknown. We performed multi-step analysis characterize modules co-expressed ADHD using data peripheral blood mononuclear cells 270 cases 279 controls....
Alcohol consumption is associated with numerous negative social and health outcomes. These associations may be direct consequences of drinking, or they reflect common genetic factors that influence both alcohol other
Tobacco use disorder (
Abstract Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship school performance whether these links explained, in part, by the liability of EA. Here, we aim to dissect polygenic contribution ADHD ASD performance, early manifestation psychopathology other psychiatric related traits To do so, tested association scores for EA, assessed influenced...
Abstract Substance use disorder (SUD) is a global health problem with significant impact on individuals and society. The presentation of SUD diverse, involving various substances, ages at onset, comorbid conditions, disease trajectories. Current treatments for struggle to address this heterogeneity, resulting in high relapse rates. often co-occurs other psychiatric mental health-related conditions that contribute the heterogeneity predispose adverse Family genetic studies highlight role...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to disorder, molecular mechanisms underlying genetic basis remain be elucidated. To explore biology, we ran two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) 143 subjects and 169 healthy controls. Through this exploratory...
Abstract Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by age-inappropriate symptoms of inattention, impulsivity and hyperactivity that persist into adulthood in the majority diagnosed children. Despite several risk factors during childhood predicting persistence ADHD adulthood, genetic architecture underlying trajectory over time still unclear. We set out to study contribution variants for across lifespan conducting meta-analyses genome-wide...