A5061490390- Child and Animal Learning Development
- Neural and Behavioral Psychology Studies
- Pain Mechanisms and Treatments
- Menstrual Health and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Lysosomal Storage Disorders Research
- Musculoskeletal pain and rehabilitation
- Neurological diseases and metabolism
- Memory and Neural Mechanisms
- Behavioral and Psychological Studies
- Neurobiology of Language and Bilingualism
- Infant Health and Development
- Attention Deficit Hyperactivity Disorder
- Cognitive Science and Mapping
- Cognitive Functions and Memory
- Pelvic floor disorders treatments
- Botulinum Toxin and Related Neurological Disorders
- Media Influence and Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Action Observation and Synchronization
- Sexual function and dysfunction studies
- Gastrointestinal motility and disorders
- Dysphagia Assessment and Management
- Nuclear Receptors and Signaling
23andMe (United States)
2023-2024
NorthShore University HealthSystem
2020-2024
University of Chicago
2020-2023
The University of Texas at Dallas
2016-2020
Loyola University Chicago
2013-2015
Abstract The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s disease (PD); however, questions remain regarding penetrance, clinical phenotype and natural history carriers. We performed a 3.5-year prospective longitudinal online study in large number 1286 genotyped carriers 109 154 controls, with without PD, recruited from 23andMe Research Cohort. collected self-reported motor non-motor symptoms every 6 months, as well demographics, family histories environmental risk...
Media violence exposure causes increased aggression and decreased prosocial behavior, suggesting that media desensitizes people to the emotional experience of others. Alterations in face processing following may result desensitization others' states. This study used scalp electroencephalography methods examine link between neural changes associated with processing. Twenty-five participants were shown a violent or nonviolent film clip then completed gender discrimination stop-signal task...
Early detection of Parkinson's disease (PD), a neurodegenerative with central and peripheral nerve involvement, ensures timely treatment access. Microbes influence nervous system health are altered in PD. We examined gut mouth microbiomes from recently diagnosed patients geographically diverse, matched case-control, shotgun metagenomics study. Here, we show greater alpha-diversity 445 PD versus 221 controls. The microbial signature includes overabundance 16 OTUs, including Streptococcus...
Abstract Multimodal hypersensitivity (MMH)—greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)—is associated with the development of chronic pain. However, previous MMH studies are restricted given their reliance on self-reported questionnaires, narrow use multimodal testing, or limited follow-up. We conducted testing an observational cohort 200 reproductive-aged women, including those at elevated risk for pelvic pain conditions and pain-free...
Some individuals who sustain traumatic brain injuries (TBIs) continue to experience significant cognitive impairments chronically (months years post injury). Many tests of executive function are insensitive these impairments, as such may only appear during complex daily life conditions. Daily often requires us divide our attention and focus on abstract goals. In the current study, we compare effects two 1-month electronic rehabilitation programs for with chronic TBI. The active program...
Abstract Increased sensory sensitivity across non-nociceptive modalities is a common symptom of chronic pain conditions and associated with development. Providing better understanding the brain–behavior relationships that underlie multimodal hypersensitivity (MMH) may clarify role MMH in development pain. We studied cohort women (n = 147) who had diary confirmation menstrual status were enriched risk factors for pelvic pain, such as dysmenorrhea increased bladder sensitivity. administered 2...
Abstract Importance The lack of information on progression, phenoconversion, and risk dementia in a large genotyped sample impedes reliable enrichment for early interventional trials Parkinson’s disease (PD). Objective To investigate PD penetrance, risk, motor/non-motor phenotypes, APOE allele effects LRRK2 G2019S GBA N370S carriers. Design Observational longitudinal case-control self-report survey study. Setting A US population-based study cohort enrolled the 23andMe, Inc. Fox Insight...
Abstract Multisensory hypersensitivity (MSH), which refers to persistent discomfort across sensory modalities, is a risk factor for chronic pain. Developing better understanding of the neural contributions disparate systems MSH may clarify its role in development We recruited cohort women ( n =147) enriched with participants menstrual pain at developing Visual sensitivity was measured using periodic pattern-reversal stimulus during EEG. Self-reported visual unpleasantness ratings were also...
Abstract The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s Disease (PD); however, questions remain regarding penetrance, clinical phenotype, and natural history carriers. We performed a 3.5 year prospective longitudinal online study in large number 1,286 genotyped carriers 109,154 controls, with without disease (PD) recruited from 23andMe Research Cohort. collected self-reported motor non-motor symptoms every six months, as well demographics, family histories,...
Clinical investigations of individuals with chronic stage traumatic brain injury (TBI) showing mild-to-moderate levels residual impairment largely use standardized neuropsychological assessments to measure executive functioning. The Hayling Sentence Completion Test (HSCT) relies upon several functions but detects cognitive impairments across studies inconsistently. We sought (a) further characterize sentence completions on the HSCT by quantifying their semantic and lexical properties (b)...
Relational thinking involves comparing abstract relationships between mental representations that vary in complexity; however, this complexity is rarely made explicit during everyday comparisons. This study explored how people naturally navigate relational and interference using a novel match-to-sample (RMTS) task with both minimal relationally directed instruction to observe changes performance across three levels of complexity: perceptual, analogy, system mappings. Individual working...
Abstract Multimodal hypersensitivity (MMH)—greater sensitivity across multiple sensory modalities (e.g., light, sound, temperature, pressure)—is hypothesized to be responsible for the development of chronic pain and pelvic pain. However, previous studies MMH are restricted given their reliance on biased self-report questionnaires, limited use multimodal quantitative testing (QST), or follow-up. Therefore, we conducted QST a cohort 200 reproductive age women at elevated risk developing...