A5003870293- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Neurological disorders and treatments
- Autoimmune Neurological Disorders and Treatments
- Obstructive Sleep Apnea Research
- Pharmacological Effects and Toxicity Studies
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- Glycogen Storage Diseases and Myoclonus
- Cytomegalovirus and herpesvirus research
- Functional Brain Connectivity Studies
- Sleep and Work-Related Fatigue
- Pregnancy and Medication Impact
- Plant Pathogens and Fungal Diseases
- Dysphagia Assessment and Management
- Plant and Fungal Interactions Research
- Fire dynamics and safety research
- Traumatic Brain Injury and Neurovascular Disturbances
- Transcranial Magnetic Stimulation Studies
- Pregnancy and preeclampsia studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Fire effects on ecosystems
Universität Innsbruck
2018-2024
Innsbruck Medical University
2012-2024
Johannes Kepler University of Linz
2024
Centre National de la Recherche Scientifique
2007
Abbott Fund
1999
York University
1951
Abstract Anti-IgLON5 disease is a rare neurological, probably autoimmune, disorder associated in many cases with specific tauopathy. Only few post-mortem neuropathological studies have been reported so far. Little known about the pathogenic mechanisms that result neurodegeneration. We investigated neuropathology of anti-IgLON5 and characterized cellular humoral inflammation. included nine (six them previously published). Median age patients was 71 years (53–82 years), median duration 6...
Parasomnias are due to a transient unstable state dissociation during entry into sleep, within or arousal from and manifest with abnormal sleep related behaviors, perceptions, emotions, dreams, autonomic nervous system activity Rapid eye movement (REM) parasomnias include REM behavior disorder (RBD), isolated recurrent paralysis nightmare disorder. Neurophysiology is key for diagnosing these disorders provides insights their pathophysiology. RBD very well characterized neurophysiological...
Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is critical due to its link α-synucleinopathies and risk injuries requires video-polysomnography (V-PSG). Usefulness screening questionnaires outside the context validation studies limited.The aim was assess performance three validated RBD compared with gold-standard V-PSG.In this bicentric prospective study, 400 consecutive subjects referred a center for first time filled (RBD Screening Questionnaire, Single Question,...
To investigate the frequency and characteristics of large muscle group movements (LMMs) during sleep in healthy adults.LMMs were scored following International Restless Legs Syndrome Study Group criteria 100 participants aged 19-77 years. A LMM was defined as a temporally overlapping increase EMG activity and/or occurrence movement artifacts at least two channels. indices durations total time (TST), NREM REM sleep, association with arousals, awakenings, respiratory events calculated....
Background Chalos et al recently developed the MR PREDICTS@24H model to predict 90 days functional outcomes in ischaemic stroke patients following endovascular treatment (EVT). We aimed validate this real-world situation of admitted a tertiary care hospital. Methods conducted retrospective cohort study including selection adult (≥18 years old) eligible for EVT tretiary center between January 2014 and May 2023. Model performance was assessed using C-statistics discrimination calibration plots...
Acyclovir resistance is rarely seen in herpes simplex virus (HSV) type I encephalitis. Prevalence rates vary between 0.5 % immunocompetent patients (Christophers et al. 1998; Fife 1994) and 3.5-10 immunocompromised (Stranska 2005). We report a 45-year-old, (negative HIV antigen/antibody testing), female patient, without previous illness who developed-after febrile prodromal stage-aphasia psychomotor slowing. Cerebral magnetic resonance imaging (cMRI) showed right temporal insular...
Abstract Study Objectives The differentiation of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) or its prodromal phase (prodromal RBD) from other disorders with motor activity during is critical for identifying α-synucleinopathy in an early stage. Currently, definite RBD diagnosis requires video polysomnography (vPSG). aim this study was to evaluate automated 3D analysis leg movements REM as objective diagnostic tool iRBD. Methods A total 122 participants (40 iRBD, 18 RBD,...
Abstract Study Objectives To evaluate macro sleep architecture and characterize rapid eye movement (REM) without atonia (RWA) by using the SINBAR excessive electromyographic (EMG) montage including mentalis upper extremity muscles in early advanced Parkinson’s disease (PD). Methods We recruited 30 patients with early- advanced-stage of PD according to Movement Disorder Society (MDS) Clinical Diagnostic Criteria. Participants were classified as early-stage if they treatment-naïve or had no...
Abstract Differentiation of central disorders hypersomnolence (DOH) is challenging but important for patient care. This study aimed to investigate whether biomarkers derived from sleep structure evaluated both by manual scoring as well with artificial intelligence (AI) algorithms allow distinction patients different DOH. We included video-polysomnography data 40 narcolepsy type 1 (NT1), 26 2 (NT2), 23 idiopathic hypersomnia (IH) and 54 participants subjective excessive daytime sleepiness...
Automatic 3D video analysis of the lower body during rapid eye movement (REM) sleep has been recently proposed as a novel tool for identifying people with isolated REM behavior disorder (iRBD), but, so far, it not validated on unseen subjects. This study aims at validating this technology in large cohort and improving its performances by also including an movements head, hands upper body.
To evaluate interrater reliability for artifact correction in the context of semiautomated quantification rapid eye movement (REM) sleep without atonia (RWA) mentalis and flexor digitorum superficialis (FDS) muscles.We included video-polysomnographies 14 subjects with apnea-hypopnea index REM (AHIREM) < 15/h 11 AHIREM ≥ 15/h. Eight had isolated behavior disorder. A validated algorithm (www.osg.be) automatically scored phasic "any" EMG activity muscle, FDS muscles. Four independent expert...
Abstract Study objectives To identify a fast and reliable method for rapid eye movement (REM) sleep without atonia (RWA) quantification. Methods We analyzed 36 video-polysomnographies (v-PSGs) of isolated REM behavior disorder (iRBD) patients 35 controls’ v-PSGs. Patients diagnosed with RBD had: i) RWA, quantified reference method, i.e. automatic artifact-corrected 3-s Sleep Innsbruck Barcelona (SINBAR) index in periods (RSPs, manually selected portions sleep); ii) v-PSG-documented...
It is not known whether patients with Juvenile Myoclonic Epilepsy (JME) differ from healthy people in decision making under risk, i.e. when the decision-making context offers explicit information about options, probabilities, and consequences already beginning. In this study, we adopted Game of Dice Task-Double (GDT-D) to investigate risk a group 36 JME (mean age 25.25/SD 5.29 years) 38 controls 26.03/SD 4.84 years). Participants also underwent comprehensive neuropsychological assessment...
To assess emotional processing and alexithymia in patients with restless legs syndrome (RLS) augmentation versus those who never had augmentation.We recruited 26 a history of (AUG), either current or past, 27 RLS treated dopamine agonists (RLS controls), 21 healthy controls (HC). All participants were screened for impulse control disorders (ICDs). Alexithymia was assessed by means the Toronto Scale - 20 (TAS-20). Facial emotion recognition tested through an eye-tracking task. Furthermore,...
The role of central sleep apnea (CSA) in pacing-induced cardiomyopathy (PICM) remains speculative. In a prospective trial entitled UPGRADE, the presence CSA was assessed by single-night polysomnography (PSG) 54 PICM patients within 1 month after left ventricular lead implantation (with biventricular stimulation still not activated). diagnosed half (n = 27). Patients with moderate or severe were randomized to cardiac resynchronization therapy (CRT) versus right pacing (RVP) double-blinded...
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Background The aim of this study was to investigate the effects on subjective and objective sleepiness a stay above large struck singing bowl compared relaxation period in silent bowl. Methods Fifty-eight healthy subjects were recruited for study, 48 participated two days, one week apart, during same timeslot. Karolinska scale used evaluate current sleepiness, relative pupillary unrest index assess sleepiness. In randomized cross-over intervention consisted 20-minute hammock while bowl,...