Erich Schmutzhard
A5064696586- Traumatic Brain Injury and Neurovascular Disturbances
- Bacterial Infections and Vaccines
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Malaria Research and Control
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Pharmacological Effects and Toxicity Studies
- Viral Infections and Vectors
- Cardiac Arrest and Resuscitation
- Parasites and Host Interactions
- Infectious Diseases and Tuberculosis
- Parasite Biology and Host Interactions
- Intensive Care Unit Cognitive Disorders
- Parasitic infections in humans and animals
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Venous Sinus Thrombosis
Innsbruck Medical University
2015-2024
Universität Innsbruck
2015-2024
Massachusetts General Hospital
2023
University of Rochester Medical Center
2023
American Academy of Neurology
2023
University of Liverpool
2022
National Health Service
2022
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2022
All India Institute of Medical Sciences
2021
World Health Organization
2013-2021
Some patients awaken from coma (that is, open the eyes) but remain unresponsive only showing reflex movements without response to command). This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: wakefulness (abbreviated UWS).Many clinicians feel uncomfortable when referring as vegetative. Indeed, most of lay public and media state pejorative connotation seems inappropriately refer these being vegetable-like. political religious...
Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view recent randomized controlled trials (RCTs) management ICH, European Stroke Organisation (ESO) has updated its evidence-based guidelines ICH.A multidisciplinary writing committee 24 researchers from 11 countries identified 20 questions relating ICH created recommendations based on evidence RCTs using Grading Recommendations...
Lyme neuroborreliosis (LNB) is a nervous system infection caused by Borrelia burgdorferi sensu lato (Bb).To present evidence-based recommendations for diagnosis and treatment.Data were analysed according to levels of evidence as suggested EFNS.The following three criteria should be fulfilled definite LNB, two them possible LNB: (i) neurological symptoms; (ii) cerebrospinal fluid (CSF) pleocytosis; (iii) Bb-specific antibodies produced intrathecally. PCR CSF culture may corroborative if...
We recently reported a novel neurological syndrome characterized by unique NREM and REM parasomnia with sleep apnea stridor, accompanied bulbar dysfunction specific association antibodies against the neuronal cell-adhesion protein IgLON5. All patients had HLA-DRB1*1001 HLA-DQB1*0501 alleles. Neuropathological findings in two revealed tauopathy restricted to neurons predominantly involving hypothalamus tegmentum of brainstem. The aim current study is describe neuropathological features...
Background and Purpose — Early identification of stroke patients at risk for fatal brain edema may be useful in selecting aggressive interventions. Prior studies suggested that early nausea/vomiting major hypodensity on baseline computed tomography (CT) were predictive herniation. Methods This study was a retrospective multicenter case-control with large middle cerebral artery (MCA) strokes admitted within 48 hours symptom onset. Medical records, laboratory data, CT scans analyzed. Cases,...
OBJECTIVE Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution outcomes among patients with hemorrhage. However, this intervention may increase the rates of rebleeding infection. To assess safety efficacy thrombolysis, we conducted a pilot, randomized, double-blind, controlled, multicenter study. METHODS Patients hemorrhage requiring ventriculostomy were randomized to receive injections normal saline solution or urokinase (25,000...
Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. acute ischemic stroke safe feasible in pilot trials. We designed study protocol to provide safer, faster therapeutic patients.Safety procedures 4°C saline infusions cooling were added the ICTuS trial (Intravascular Cooling Treatment of Stroke) protocol. A femoral venous intravascular catheter intravenous recombinant tissue-type plasminogen activator...
<h3>Objective:</h3> To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <h3>Methods:</h3> Associations ICH sites poor (death [6] or major disability [3–5] modified Rankin Scale) European Quality Life Scale (EQ-5D) utility scores at 90 days were assessed logistic regression models. <h3>Results:</h3> Of 2,066 patients included...
An epidemic illness characterized by head nodding associated with onchocerciasis has been described in eastern Africa since the early 1960s; we summarize published reports and recent studies. Onset of occurs previously healthy 5-15-year-old children is often triggered eating or cold temperatures accompanied cognitive impairment. Its incidence increased Uganda South Sudan over past 10 years. Four case-control studies identified modest inconsistent associations. There were nonspecific lesions...
<h3>Objectives:</h3> To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved in patients with acute intracerebral hemorrhage (ICH). <h3>Methods:</h3> INTERACT2 was an open, blinded endpoint, randomized controlled trial 2,839 ICH within 6 hours onset elevated systolic (SBP) (150–220 mm Hg) who were allocated receive (target SBP <140 Hg 1 hour, lower limit 130 for treatment cessation) or guideline-recommended <180...
Abstract Introduction Daily interruption of sedation (IS) has been implemented in 30 to 40% intensive care units worldwide and may improve outcome medical patients. Little is known about the benefit IS acutely brain-injured Methods This prospective observational study was performed a neuroscience unit tertiary-care academic center. Twenty consecutive severely patients with multimodal neuromonitoring were analyzed for levels brain lactate, pyruvate glucose, intracranial pressure (ICP),...
There is a substantial amount of evidence from animal models that early brain injury (EBI) may play an important role for secondary after aneurysmal subarachnoid hemorrhage (aSAH). Cerebral microdialysis (CMD) allows online measurement metabolites, including the pro-inflammatory cytokine interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9), which indicative disruption blood-brain barrier.Twenty-six consecutive poor-grade aSAH patients with multimodal neuromonitoring were analyzed...
BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, substantial defined as ≥1, ≥2, ≥3, ≥4 points decrease, respectively, National Institutes Health Stroke Scale 24 hours to 7 days...
Background and Purpose —Intraventricular hemorrhage (IVH) remains associated with high morbidity mortality. Therapy external ventricular drainage alone has not modified outcome in these patients. Methods —Twelve pilot IVH patients who required were prospectively treated intraventricular urokinase followed by the randomized, double-blinded allocation of 8 to either treatment or placebo. Observed 30-day mortality was compared predicted obtained use a previously validated method. Results...