A5061231392- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- COVID-19 and Mental Health
- Pharmacological Receptor Mechanisms and Effects
- Nicotinic Acetylcholine Receptors Study
- Climate Change and Health Impacts
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Gastroesophageal reflux and treatments
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Cerebrovascular and Carotid Artery Diseases
- Zebrafish Biomedical Research Applications
- Hemodynamic Monitoring and Therapy
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Diet and metabolism studies
Johannes Kepler University of Linz
2024-2025
Innsbruck Medical University
2018-2024
Universität Innsbruck
2018-2024
UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik
2018-2024
Carol Davila University of Medicine and Pharmacy
2017-2024
Kepler Universitätsklinikum
2024
MIT University
2018
Iuliu Hațieganu University of Medicine and Pharmacy
2018
University Medical Center Hamburg-Eppendorf
2017
Universität Hamburg
2017
Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery acute infection. Here, the aim was to describe natural history of neurological manifestations over 1 year COVID-19.A prospective, multicentre, longitudinal cohort study in COVID-19 survivors performed. At a 3-month and 1-year follow-up, patients were assessed for impairments by examination standardized test battery including assessment hyposmia (16-item Sniffin' Sticks test), cognitive deficits...
To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental physical subcategories 3 months after diagnosis COVID-19.
Subarachnoid hemorrhage is a life-threatening disease associated with high mortality and morbidity. A substantial number of patients develop systemic inflammatory response syndrome. We aimed to identify risk factors for syndrome development evaluate the role on patients' outcome.Retrospective observational cohort study prospectively collected data.Neurocritical care unit at tertiary academic medical center.Two-hundred ninety-seven consecutive nontraumatic subarachnoid admitted neurologic ICU...
Abstract Background After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which directly linked to body temperature, may influence physiology. Increased and/or BT cause secondary damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion (CPP), and outcome. Methods Collaborative European NeuroTrauma Effectiveness Research in Traumatic Injury (CENTER-TBI), a prospective multicenter longitudinal study TBI Europe Israel, includes high resolution...
Background Chalos et al recently developed the MR PREDICTS@24H model to predict 90 days functional outcomes in ischaemic stroke patients following endovascular treatment (EVT). We aimed validate this real-world situation of admitted a tertiary care hospital. Methods conducted retrospective cohort study including selection adult (≥18 years old) eligible for EVT tretiary center between January 2014 and May 2023. Model performance was assessed using C-statistics discrimination calibration plots...
Brain tissue hypoxia (PbtO2 < 20 mmHg) is common after subarachnoid hemorrhage (SAH) and associated with poor outcome. Recent data suggest that brain oxygen optimization feasible reduces the time spent PbtO2 mmHg from 45 to 16% in patients severe traumatic injury. Here, we intended quantify burden despite implementation of a protocolized treatment approach poor-grade SAH identify simultaneous occurrence pathologic values potentially amenable treatment. We present bi-centric observational...
Optimal fluid management is important in patients with acute brain injury, including subarachnoid hemorrhage. We aimed to examine the relationship between daily intake and balance hospital complications functional outcome.Retrospective observational cohort study.Neurocritical care unit at a tertiary academic medical center.Two-hundred thirty-seven consecutive nontraumatic hemorrhage admitted neurologic ICU 2010 2016.Total amount of fluids were calculated over 15 days. Using multivariate...
Nimodipine is recommended to prevent delayed cerebral ischemia in patients with spontaneous subarachnoid hemorrhage (SAH). Here, we studied hemodynamic side effects of different nimodipine formulations (per os [PO] and intravenous [IV]) SAH undergoing continuous blood pressure monitoring.This observational cohort study includes consecutive (271 included the IV group, 49 PO group) admitted a tertiary care center between 2010 2021. All received prophylactic or nimodipine. Hemodynamic responses...
Background: Infectious complications (IC) commonly occur in patients with intracerebral hemorrhage (ICH) and are associated increased length of hospitalization (LOS) poor long-term outcome. Little is known about early ICH-related predictors for the development IC to allow appropriate allocation resources timely initiation preventive measures. Methods: We prospectively enrolled 229 consecutive non-traumatic ICH admitted neurocritical care (NICU) a tertiary hospital. Patients were screened...
Background and Purpose— Global cerebral edema occurs in up to 57% of patients with subarachnoid hemorrhage (SAH) is associated prolonged hospital stay poor outcome. Recently, admission brain was successfully graded using a simplified computed tomography-based semiquantitative score (subarachnoid early [SEBES]). Longitudinal evaluation the SEBES grade may discriminate rapid delayed resolution after SAH. Here, we aimed describe study relationship between this radiographic biomarker course...
Abstract Background Despite improvements in the critical care management of subarachnoid hemorrhage (SAH), a substantial number patients still suffer from disabilities. In most areas world, longitudinal follow-up is not routinely performed, and patient’s trajectory remains unknown. Methods We prospectively collected data 298 consecutive with spontaneous SAH evaluated clinical trajectories at discharge, 3 months, 1 year after SAH. subgroup transferred to local neurorehabilitation center...
There is no uniform definition for cerebral microdialysis (CMD) probe location with respect to focal brain lesions, and the impact of CMD-probe on measured molecule concentrations unclear. We retrospectively analyzed data 51 consecutive subarachnoid hemorrhage patients CMD-monitoring between 2010 2016 included in a prospective observational cohort study. Microdialysis was assessed all computed tomography (CT) scans performed during defined as perilesional presence hypodense or hyperdense...
Background and purpose Early pharmacological deep vein thrombosis ( DVT ) prophylaxis is recommended by guidelines, but rarely started within 48 h. We aimed to analyze the effect of early (within h) versus late (>48 on hematoma expansion HE outcome in patients with spontaneous intracerebral hemorrhage ICH ). Methods analyzed 134 consecutive admitted a tertiary neurointensive care unit diagnosed , without previous anticoagulation, severe coagulopathy, evacuation, withdrawal therapy or...
OBJECTIVE In patients with cervical spondylotic myelopathy (CSM), the motor system may undergo progressive functional/structural changes rostral to lesion, and these be associated clinical disability. The extent which have a prognostic value in recovery after surgical treatment is not yet known. this study, magnetic resonance spectroscopy (MRS) was used test 2 primary hypotheses. 1) Based on evidence of corticospinal spinocerebellar, rubro-, or reticulospinal tract degeneration/dysfunction...
Abstract Background Patients with spontaneous subarachnoid hemorrhage (SAH) frequently encounter cognitive dysfunction and mental health issues negative effects on health-related quality of life (HR-QoL). Here, we aimed to describe the prevalence deficits, problems, HR-QoL impairments 1 year after SAH. Methods In this prospective observational study, 177 patients SAH admitted our neurointensive care unit over a time span ten years followed invitation for an in-person 1-year follow-up,...
Intravenous nonsteroidal anti-inflammatory drugs and nonopioid analgesics are used to achieve normothermia or relieve pain in patients with aneurysmal subarachnoid hemorrhage (aSAH). We investigated the effects of paracetamol (1 g), diclofenac (75 mg) metamizole g) on systemic cerebral hemodynamics temperature during febrile nonfebrile episodes after aSAH. Prospectively collected data from 77 consecutive poor-grade aSAH invasive neuromonitoring were included. The burden occurrence...
Subarachnoid hemorrhage (SAH) is a devastating disease associated with high mortality and morbidity. Besides neurological sequelae, neuropsychological deficits largely contribute to patients' long-term quality of life. Little known about the pituitary gland volume (PGV) after SAH compared healthy referents association PGV outcome including cognitive function. Sixty consecutive non-traumatic patients admitted intensive care unit between 2010 2014 were enrolled. 3-Tesla magnetic resonance...
Elevated body temperature (T core ) is associated with poor outcome after subarachnoid hemorrhage (SAH). Brain brain usually higher than T . However, the implication of this difference delta remains unclear. We aimed to study factors and its association outcome. included 46 SAH patients undergoing multimodal neuromonitoring, for a total 7879 h averaged data , cerebral blood flow, perfusion pressure, intracranial pressure metabolism (CMD). Three-months good functional was defined as modified...
Effects of brain temperature modulation on cerebral hemodynamics are unclear. We aimed at investigating changes dynamic autoregulation (AR) indices during induction deep hypothermia (HT) in a porcine model mimicking the clinical scenario accidental HT. Thirteen pigs were surface-cooled to core 28°C. High-frequency monitoring included temperature, mean arterial blood pressure (MAP), intracranial (ICP), tissue oxygen tension (PbtO2), and regional saturation (rSO2) assessed by near-infrared...
Abstract Background Despite the tremendous impact of swallowing disorders on outcome following ischemic stroke, little is known about incidence dysphagia after subarachnoid hemorrhage (SAH) and its contribution to hospital complications, length intensive care unit stay, functional outcome. Methods This a retrospective analysis an ongoing prospective cohort study. Swallowing ability was assessed in consecutive non-traumatic SAH patients admitted our neurological using Bogenhausen Dysphagia...
Cardiac complications are common after spontaneous intracerebral hemorrhage (ICH). In this study we intended to investigate factors associated with higher alterations in heart rate and their impact on outcome.Eighty-eight ICH patients were included. A simplified approach calculate variability (HRSD) analogy systolic blood pressure (SBPSD) daily standard deviations of HR the acute (first 24 h) subacute phase (day1-day7) was used. Using multivariable regression, HRSD association between poor...
Fluid management in patients after subarachnoid hemorrhage (SAH) aims at the optimization of cerebral blood flow and brain oxygenation. In this study, we investigated effects hemodynamic on oxygenation by integrating advanced invasive neuromonitoring.This observational cohort bi-center study included data consecutive poor-grade SAH who underwent pulse contour cardiac output (PiCCO) monitoring neuromonitoring. was guided transpulmonary thermodilution system aimed euvolemia (cardiac index, CI...
Intensive care unit (ICU) acquired weakness is a major contributor to poor functional outcome of ICU patients. Quantification temporal muscle volume assessed on routine computed tomography (CT) scans may serve as biomarker for wasting in patients suffering from acute brain injury.This retrospective analysis prospectively collected data. Temporal was head CT consecutive with spontaneous subarachnoid hemorrhage within prespecified time frames (on admission, then weekly ± 2 days). Whenever...