Werner O. Hackl

ORCID: 0000-0002-2688-3396
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About
Contact & Profiles
Research Areas
  • Electronic Health Records Systems
  • Data Quality and Management
  • Biomedical Text Mining and Ontologies
  • Pharmaceutical Practices and Patient Outcomes
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Intracranial Aneurysms: Treatment and Complications
  • Online and Blended Learning
  • Health and Medical Studies
  • Nursing Diagnosis and Documentation
  • Pharmacovigilance and Adverse Drug Reactions
  • Online Learning and Analytics
  • Healthcare Technology and Patient Monitoring
  • Ion channel regulation and function
  • Clinical practice guidelines implementation
  • Patient Safety and Medication Errors
  • Intensive Care Unit Cognitive Disorders
  • Social and Demographic Issues in Germany
  • Respiratory Support and Mechanisms
  • Innovative Teaching and Learning Methods
  • Mobile Health and mHealth Applications
  • Cardiac electrophysiology and arrhythmias
  • Artificial Intelligence in Healthcare
  • Cardiac Arrest and Resuscitation
  • Anesthesia and Sedative Agents
  • E-Learning and Knowledge Management

UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik
2015-2024

MIT University
2012-2018

University of Health Science
2015

University of Health Sciences Antigua
2014

Medical University of Vienna
2013

University Hospital Heidelberg
2013

Radboud University Nijmegen
2013

Innsbruck Medical University
2013

Medical University of Graz
2013

German Cancer Research Center
2013

Despite the excellent prognosis of Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, type I endometrial cancers, a substantial number patients experience recurrence and die from this disease. We analyzed value immunohistochemical L1CAM determination to predict clinical outcome.We conducted retrospective multicenter cohort study determine expression by immunohistochemistry in 1021 cancer specimens. The Kaplan-Meier method Cox proportional hazard model were applied for...

10.1093/jnci/djt144 article EN JNCI Journal of the National Cancer Institute 2013-06-18

The hypothesis that forced-air warming preserves core temperature better than circulating-water mattresses was tested in: (a) 16 adults undergoing major maxillofacial surgery, including radical node resection and flap reconstruction; (b) 53 hip arthroplasty, having approximately 25% of their body surface area available for warming; (c) 20 infants minor surgery; (d) 10 young children pelvic or femoral osteotomies. Patients each type surgery were randomly assigned to (approximately 40 degrees...

10.1213/00000539-199307000-00018 article EN Anesthesia & Analgesia 1993-07-01

There is a substantial amount of evidence from animal models that early brain injury (EBI) may play an important role for secondary after aneurysmal subarachnoid hemorrhage (aSAH). Cerebral microdialysis (CMD) allows online measurement metabolites, including the pro-inflammatory cytokine interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9), which indicative disruption blood-brain barrier.Twenty-six consecutive poor-grade aSAH patients with multimodal neuromonitoring were analyzed...

10.1186/s13054-015-0809-9 article EN cc-by Critical Care 2015-02-23

Monocyte phenotype, their phagocytic capacity as well the cytokine production from 10 patients with sepsis low interleukin-6 (IL-6) serum concentrations (<1000 pg/mL) and 8 high IL-6 (⩾1000 plasma were investigated within 24 hours of fulfilling criteria for sepsis. Monocytes levels had higher human leukocyte antigen (HLA)-DR, HLA-ABC, CD64, CD71, tumor necrosis factor-α (TNF-α) IL-8, monocytes to phagocytose, was significantly elevated. Of IL-6, 4 died. In contrast, all survived until day...

10.1086/317499 article EN Clinical Infectious Diseases 2000-12-01

Abstract Background Computerized physician order entry systems (CPOE) can reduce the number of medication errors and adverse drug events (ADEs) in healthcare institutions. Unfortunately, they tend to produce a large partly irrelevant alerts, turn leading alert overload causing fatigue. The objective this work is identify factors that be used prioritize present alerts depending on 'context' clinical situation. Methods We combination literature searches expert interviews validate possible...

10.1186/1472-6947-11-35 article EN cc-by BMC Medical Informatics and Decision Making 2011-05-25

While Nursing Informatics competencies seem essential for the daily work of nurses, they are not formally integrated into nursing education in Austria, Germany and Switzerland, nor there any national educational recommendations. The aim this paper is to show how such recommendations can be developed, what competency areas most relevant three countries implemented practice. To end, a triple iterative procedure was proposed applied starting with health informatics other professionals, matching...

10.1080/17538157.2018.1497635 article EN Informatics for Health and Social Care 2018-08-27

Social presence is a key element in collaborative/cooperative learning. In online learning environments, it challenging to measure the current state of social presence. This work aims identify measures We manually coded 3546 students' postings (n = 49 students). selected from network analysis and indices derived log data as potential indicators. conducted an exploratory path define which indicators appropriately describe The size individual egocentric student's (path coefficient −0.56**)...

10.1016/j.iheduc.2022.100894 article EN cc-by-nc-nd The Internet and Higher Education 2022-10-01

Summary Background: Progress in the medical sciences, together with related technologies, past has led to higher specialization and created a strong need exchange health information across institutional borders. The concept of electronic records (EHR) was introduced fulfill these needs. Remarkably, many EHR introduction projects ran into trouble, not least because they lacked acceptance among physicians. Negative emotions, such as anxiety fear due lack information, may cause change barriers...

10.3414/me10-02-0020 article EN Methods of Information in Medicine 2010-11-08

To analyze the attitude of physicians towards alerting in CPOE systems different hospitals countries, addressing various organizational and technical settings view not currently using a CPOE.A cross-sectional quantitative qualitative questionnaire survey. We invited 2,600 eleven from nine countries to participate. Eight had use, three participating were system.1,018 participated. The general is positive found be mostly independent country, specific their personal experience with systems....

10.3414/me12-02-0007 article EN Methods of Information in Medicine 2012-11-28

Recent evidence suggests axonal injury after aneurysmal subarachnoid haemorrhage (aSAH). The microtubule-associated protein, tau, has been shown to be elevated in the cerebrospinal fluid aSAH, however, brain extracellular tau levels and their relation long-term neurological cognitive outcomes have not investigated.Serial cerebral microdialysis (CMD) samples were collected from 22 consecutive aSAH patients with multimodal neuromonitoring determine CMD-total-tau by ELISA. was analysed...

10.1136/jnnp-2013-307326 article EN Journal of Neurology Neurosurgery & Psychiatry 2014-04-16

SUMMARY Induction, emergence and recovery characteristics were compared during sevoflurane or halothane anaesthetic in a large (428) multicentre, international study of children undergoing elective inpatient surgical procedures. Two hundred fourteen each group underwent inhalation induction with nitrous oxide/oxygen halothane. Incremental doses either drug added until loss eyelash reflex was achieved. Steady state concentrations anaesthesia maintained the end surgery when agents terminated...

10.1111/j.1460-9592.1996.tb00452.x article EN Pediatric Anesthesia 1996-07-01

BACKGROUND: Using serum, plasma or tumor tissue specimens from biobanks for biomarker discovery studies is attractive as samples are often readily available. However, storage over longer periods of time can alter concentrations proteins in those specimens. We therefore assessed the bias estimates association case-control conducted using banked when maker levels changed single markers and also multiple correlated simulations. Data a small laboratory experiment serum guided choices simulation...

10.1186/2043-9113-1-9 article EN cc-by Journal of Clinical Bioinformatics 2011-01-01

Even if English is the leading language for international communication, it essential to keep in mind that research runs at local level by teams generally communicating their local/national language, especially Europe among European projects. Therefore, Federation Medical Informatics - Working Group on Health Inter-regional Cooperation" has one objective: To develop a multilingual ontology focusing and Digital as collaboration tool improves and, particular, collaborations. We have developed...

10.1016/j.ijmedinf.2022.104860 article EN cc-by International Journal of Medical Informatics 2022-08-29

To determine what information can be helpful in prioritizing and presenting medication alerts according to the context of clinical situation. assess usefulness different ways delivering user.An international Delphi study with two quantitative rounds. 69 researchers expertise computerized physician order entry (CPOE) systems were asked estimate 20 possible factors, potential impact six innovative alert on adverse drug event (ADE) rates.Participants identified following top five items (in...

10.1136/amiajnl-2010-000006 article EN Journal of the American Medical Informatics Association 2011-06-22

Spreading depolarizations (SDs) are highly active metabolic events, commonly occur in patients with intracerebral hemorrhage (ICH) and may be triggered by fever. We investigated the dynamics of brain-temperature (T brain ) core-temperature core relative to occurrence SDs. Twenty consecutive comatose ICH multimodal electrocorticograpy (ECoG) T monitoring perihematomal area were prospectively enrolled. Clusters SDs defined as ≥2 SDs/h. Generalized estimating equations used for statistical...

10.1177/0271678x17703940 article EN Journal of Cerebral Blood Flow & Metabolism 2017-04-24

Objective: In this synopsis, the editors of Clinical Information Systems (CIS) section IMIA Yearbook Medical Informatics overview recent research and propose a selection best papers published in 2022 CIS field. Methods: The follow systematic approach to gather relevant articles select for section. This year, they updated query incorporate topic telemedicine removed search terms related geographic information systems. revised resulted larger number identified papers, necessitating appointment...

10.1055/s-0043-1768756 article EN cc-by-nc-nd Yearbook of Medical Informatics 2023-08-01

Summary Objectives: To present European reflections on the concept of eHealth and emerging challenges related to further development in Europe. Methods: A survey with 10 questions was distributed representatives national member associations Federation Medical Informatics (EFMI). Results: The results document a shift from constricting ICT-orientation entire health system where strategies, organizational change, appropriate technological infrastructure are singled out as important aspects....

10.1055/s-0038-1638833 article EN Yearbook of Medical Informatics 2013-08-01

Diclofenac, a nonsteroidal antiinflammatory drug, is commonly used as antipyretic therapy in intensive care. The purpose of this study was to investigate the effects parenteral diclofenac infusion on brain homeostasis, including brain-tissue oxygen tension (PbtO2) and metabolism after aneurysmal subarachnoid hemorrhage (aSAH).We conducted prospective, observational with retrospective analysis 21 consecutive aSAH patients multimodal neuromonitoring. Cerebral perfusion pressure (CPP), mean...

10.1186/cc12714 article EN cc-by Critical Care 2013-05-12

Abstract Introduction Elevated brain potassium levels ([K + ]) are associated with neuronal damage in experimental models. The role of extracellular [K ] patients poor-grade aneurysmal subarachnoid hemorrhage (aSAH) and its association load, metabolic dysfunction outcome has not been studied so far. Methods Cerebral microdialysis (CMD) samples from 28 poor grade aSAH were analyzed for CMD 12 consecutive days after ictus, time-matched to hemodynamic parameters as well corresponding plasma ]....

10.1186/cc13916 article EN cc-by Critical Care 2014-06-11

Abstract The amino-acids tryptophan, phenylalanine and tyrosine seem to play an important role in the pathophysiology of depressive disorders. We measured daily brain extracellular levels these using cerebral microdialysis (CMD) high performance liquid chromatography 26 consecutive subarachnoid hemorrhage (SAH) patients associated them with presence Patients were grouped as follows: medical history depression (prior SAH), antidepressant intake 12 months after SAH (but not before), or...

10.1038/s41598-019-39569-5 article EN cc-by Scientific Reports 2019-02-26

The growing use of technology for mathematics in higher education opens new pedagogical and technological challenges teachers. objective this study was to analyze the teaching approaches technology-related competencies 29 teachers (15 females 14 males) from nine European countries. After conducting semi-structured interviews, Approaches Teaching Inventory (ATI-16) Technological Pedagogical Content Knowledge (TPACK) framework survey were applied. results show large individual variations...

10.3390/educsci10120354 article EN cc-by Education Sciences 2020-11-26

This study scrutinizes free AI tools tailored for supporting literature review and analysis in academic research, emphasizing their response to direct inquiries. Through a targeted keyword search, we cataloged relevant evaluated output variation source validity. Our results reveal spectrum of qualities, with some integrating non-academic sources others depending on outdated information. Notably, most showed lack transparency selection. highlights two key limitations: the exclusion commercial...

10.3233/shti240038 article EN Studies in health technology and informatics 2024-04-26
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