A5061545433- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Endometriosis Research and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Testicular diseases and treatments
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- BRCA gene mutations in cancer
Innsbruck Medical University
2016-2025
Universität Innsbruck
2014-2025
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2004-2025
University Hospital Innsbruck
1995-2024
Belfast Health and Social Care Trust
2019
Arbeitsgemeinschaft Gynäkologische Onkologie Studiengruppe
2018
AGO Austria
2011-2016
Medical University of Vienna
2011-2013
University Hospital Heidelberg
2013
Radboud University Nijmegen
2013
Abstract Purpose: The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated poor survival different malignancies. aim the presented study was determine prognostic effect mRNA expression (reflecting tissue content Treg) ovarian carcinoma and its relation cytokines, such as IFN-γ. Experimental Design: Total RNA isolated from 99 14 healthy biopsies. Real-time PCR for done...
Despite the excellent prognosis of Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, type I endometrial cancers, a substantial number patients experience recurrence and die from this disease. We analyzed value immunohistochemical L1CAM determination to predict clinical outcome.We conducted retrospective multicenter cohort study determine expression by immunohistochemistry in 1021 cancer specimens. The Kaplan-Meier method Cox proportional hazard model were applied for...
Abstract Hypomethylation of some portions the genome and hypermethylation others are very frequent in human cancer. The hypomethylation often involves satellite 2 (Sat2) DNA juxtacentromeric (centromere-adjacent) region chromosome 1. In this study, we analyzed methylation centromeric 115 ovarian cancers, 26 non-neoplastic specimens, various normal somatic tissue standards. We found that both types samples increased significantly from toward cancer tissue. Furthermore, strong was more...
Recently, the new 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer (EC) critically integrating pathological molecular features was published. The present study evaluated clinical impact FIGO by comparing it to previous 2009 system.This is an international, pooled retrospective 519 EC patients who underwent primary treatment (and characterisation) at three European Society Gynaecological Oncology (ESGO) accredited centres in...
Germ cell tumors (GCTs) represent about 5% of urological cancers affecting mostly younger males with increasing incidence in the last decades. GCTs are very sensitive to cisplatin-based therapy and highly curable regardless metastatic stage, likely based on having inherited unique mechanisms sensitivity DNA damage other stressors prevent germline mutations. Here, we present first case a 60-year Caucasian male heavily pretreated, cisplatin-refractory extragonadal non-seminomatous GCT...
Abstract Despite strong homology, the roles of TP53 and TP73 in tumorigenesis seem to be fundamentally different. In contrast TP53, tumor-associated overexpression many different cancers, combined with virtual absence inactivating mutations lack a cancer phenotype null mouse are inconsistent suppressor function but instead support an oncogenic function. The discovery NH2-terminally truncated p73 isoforms, collectively called ΔTAp73, is now focus intense interest because they act as potent...
The management of recurrent ovarian cancer remains controversial. Single-agent topotecan is an established treatment option, and preliminary evidence suggests improved tumor control by combining with etoposide or gemcitabine.Women relapsed after primary surgery platinum-based chemotherapy were randomly assigned to monotherapy 1.25 mg/m(2)/d, 1.0 mg/m(2) plus oral 50 mg/d, 0.5 mg/m(2)/d gemcitabine 800 on day 1 600 8 every 3 weeks. Patients stratified for platinum-refractory...
Abstract Purpose: The major obstacle in treating ovarian cancer is the rapid development of platinum resistance during therapy. Deregulation members E2F family transcription factors crucially involved carcinogenesis and probably mechanisms underlying resistance. We therefore investigated relevance whole set predicting clinical outcome their significance Experimental Design: Real-time PCR all was done from 77 carcinomas, defined as our training set, 8 healthy control samples. correlation with...
Endometrial carcinomas (ECs) are classified into type 1 (less aggressive) and 2 (aggressive) tumours that differ in genetic alterations. So far, reliable immunohistochemical markers can identify patients with high risk for recurrence rare. We have defined the expression of L1 cell adhesion molecule (L1CAM), a biomarker previously identified EC, compared its to oestrogen receptor (ER)/progesterone (PR) E-cadherin. found L1CAM was absent normal endometrium vast majority endometrioid ECs (type...
// Verena Wieser 1 , Inge Gaugg Martina Fleischer Giridhar Shivalingaiah 2, 5 Soeren Wenzel 2 Susanne Sprung 3 Sigurd F. Lax 4 Alain G. Zeimet Heidelinde Fiegl and Christian Marth Department of Obstetrics Gynecology, Medical University Innsbruck, Innsbruck 6020, Austria Division Human Genetics, Institute Pathology, Hospital Graz Süd-West, Academic Teaching the Graz, 8020, Present address: Biological Chemistry, Biocenter, Correspondence to: Fiegl, email: Heidelinde.Fiegl@i-med.ac.at Keywords:...
// Maximilian Boesch 1,2 , Alain G. Zeimet 3 Daniel Reimer Stefan Schmidt 1 Guenther Gastl Walther Parson 4 Franziska Spoeck Jiri Hatina 5 Dominik Wolf 1,6,* Sieghart Sopper 1,2,* Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria 2 Tyrolean Cancer Research Institute, Department of Gynecology and Obstetrics, Institute Legal Medicine, Biology Biomedical Centre, Faculty Pilsen, Charles University Prague, Czech Republic 6 Clinic III, Oncology, Hematology Rheumatology, Bonn...
An increasing body of evidence shows that miR-34 family has tumor suppressive properties mediating apoptosis, cell cycle arrest and senescence. In ovarian cancer, miR34 members were found to be under expressed. Particularly miR-34a been revealed a direct transcriptional target p53 which is frequently mutated in epithelial carcinomas especially high grade serous cancer. Moreover, methylation CpG Islands was down-regulate expression. The aim this study investigate the clinical relevance mir34a...
Clonal hematopoiesis (CH) driven by mutations in the DNA damage response (DDR) pathway is frequent patients with cancer and associated a higher risk of therapy-related myeloid neoplasms (t-MNs). Here, we analyzed 423 serial whole blood plasma samples from 103 relapsed high-grade ovarian receiving carboplatin, poly(ADP-ribose) polymerase inhibitor (PARPi) heat shock protein 90 (HSP90i) treatment within phase II EUDARIO trial using error-corrected sequencing 72 genes. DDR-driven CH was...
Abstract Purpose: We aimed to determine the clinical role of p53 family members and p73 in responsiveness platinum-based chemotherapy survival ovarian cancer, considering their cross-talk polymorphism at codon 72. Experimental Design: A detailed analysis a series 122 cancers was done. used functional yeast-based assay mutational status. Red yeast colonies, indicating mutant p53, were subsequently sequenced specific alteration. mutations divided into two groups according previous...