Siel Olbrecht
A5079039857- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- Genetic Associations and Epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Family Support in Illness
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Protein Kinase Regulation and GTPase Signaling
KU Leuven
2014-2025
VIB-KU Leuven Center for Cancer Biology
2020-2023
The European Academy of Gynaecological Surgery
2020-2022
Cancer Institute (WIA)
2019-2020
Australia New Zealand Gynaecological Oncology Group
2019
The development of guidelines is one the core activities European Society for Medical Oncology (ESMO) and Gynaecologial (ESGO), as part mission both societies to improve quality care patients with cancer across Europe. ESMO ESGO jointly developed clinically relevant evidence-based recommendations in several selected areas order women ovarian cancer. ESMO–ESGO consensus conference on was held April 12–14, 2018 Milan, Italy, comprised a multidisciplinary panel 40 leading experts management...
High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characterisation of this but the lack strong prognostic or predictive correlations with these subtypes currently hinders their clinical implementation. Stromal admixture profoundly affects impact molecular subtypes,...
A bstract The stromal compartment of the tumour microenvironment consists a heterogeneous set tissue-resident and tumour-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what extent this heterogeneity similar between cancers affecting different organs. Here, we profile 233,591 single cells from patients with lung, colorectal, ovary breast (n=36) construct pan-cancer blueprint cell using single-cell RNA protein-based technologies. We identify 68...
Abstract Background Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo‐ovarian high‐grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification overexpression with survival, but to date no large‐scale, histotype‐specific validation has been performed. The hypothesis was that high‐level of overexpression, as well combination the two, are linked shorter overall survival HGSC. Methods Within Ovarian Tumor Tissue...
Abstract Background In estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 (HER-2) negative breast cancers, the progesterone (PR) is an independent prognostic marker. Little known about value of PR by tumor grade. We assessed this in two datasets. Patients and Methods Women with primary operable, invasive ER+ HER-2 cancer diagnosed between 2000 2012, treated at University Hospitals Leuven, were included. association status subtype (grade 1–2 vs. grade 3) distant...
Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions cell types contributing cfDNA. Based on cfDNA fragmentation patterns, the deviation in footprints was quantified between diagnosed ovarian cancer patients and healthy individuals. Multinomial modeling subsequently applied capture these deviations a per sample footprint score. Validation performed 271 cfDNAs pre-surgically collected from women with an adnexal mass. We confirmed that scores were...
Abstract Background Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported multiple solid cancers, and expression associated with poor prognosis. This manuscript compares TF across various tumor types via immunohistochemistry a single study, which not performed previously. Aims To increase insight the prevalence cellular localization of cancer types, we detailed systematic analysis obtained from patients ovarian, esophageal, bladder, cervical,...
<h3>Introduction/Background</h3> Previous studies have shown that CTNNB1 mutations increase the risk of recurrence in endometrial cancer (EC), particularly non-specific molecular profile (NSMP) subset.<sup>1</sup> is a β-catenin-encoding gene, and are present approximately 20–25% EC. This study investigates clinicopathological differences between mutated (CTNNB1mut) tumours wild type (CTNNB1wt) tumours, including progression free survival (PFS) overall (OS) <h3>Methodology</h3> retrospective...
Abstract Protein aggregation is an underappreciated mechanism that may contribute to the loss- and oncogenic-gain-of-function of mutant tumor suppressors such as p53 axin. In present study, we describe amyloid-like behaviour second most frequently mutated suppressor in human cancer, PTEN. silico analysis revealed a particularly high vulnerability for this protein, which was corroborated by vitro assays. cultured cells, found under stress conditions, PTEN readily undergoes result mutation....
<h3>Introduction/Background</h3> Non-epithelial ovarian tumours encompass a heterogeneous group of neoplasms that mainly include germ cell (GCT) and sex-cord stromal (SCST). These are characterised by an extensive inter- intratumoral heterogeneity. By applying single-cell RNA sequencing (scRNA-seq), we attempt to elucidate the complexity tumour microenvironment. <h3>Methodology</h3> We performed scRNA-seq 66 919 cells collected from 12 patients. Most fresh tissue samples were derived SCST...
Abstract Background After menopause, an absent PgR predicts distant metastases (DM) in patients with ER positive HER-2 negative invasive BC. Yamamoto et al. (JCO 2013) questioned the prognostic effect of PR premenopausal patients, as ovarian estrogens might affect expression. We investigated on DM free interval (DMFI) and BC specific survival (BCSS) by age at diagnosis surrogate marker for menopause. Patients methods Retrospective data consecutive a primary operable (1/1/2000 - 31/12/2009)...
Abstract The tumor microenvironment (TME) shapes response to immune checkpoint blockade (ICB). Several pan-cancer single-cell RNA-sequencing (scRNA-seq) analyses have reported how TME heterogeneity profoundly differs between cancer types. These studies mainly focused on one cell type (e.g., T-cells) and combined different technologies bioinformatics pipelines with data being collected from both published newly generated datasets. A comprehensive scRNA-seq map of the involving all types is...