A5078015467- Ovarian cancer diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Endometriosis Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Mathematical Biology Tumor Growth
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Cancer Immunotherapy and Biomarkers
- Pregnancy-related medical research
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Gynecological conditions and treatments
- Intestinal and Peritoneal Adhesions
- Pancreatic and Hepatic Oncology Research
- Cancer Risks and Factors
- Menstrual Health and Disorders
- Renal cell carcinoma treatment
Brigham and Women's Hospital
2017-2025
Harvard University
2017-2025
Boston Children's Hospital
2020-2025
Fred Hutch Cancer Center
2025
University of Massachusetts Boston
2023
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2022
Nippon Medical School Hospital
2020
Minoh City Hospital
2012-2017
Itami City Hospital
2016
Abstract Most ovarian cancers are infiltrated by prognostically relevant activated T cells 1–3 , yet exhibit low response rates to immune checkpoint inhibitors 4 . Memory B cell and plasma infiltrates have previously been associated with better outcomes in cancer 5,6 but the nature functional relevance of these responses controversial. Here, using 3 independent cohorts that total comprise 534 patients high-grade serous cancer, we show robust, protective humoral dominated production...
Limited data exist on the performance of high-throughput proteomics profiling in epidemiological settings, including impact specimen collection and within-person variability over time. Thus, Olink (972 proteins) SOMAscan7Kv4.1 (7322 proteoforms 6596 assays were utilized to measure protein concentrations archived plasma samples from Nurses' Health Studies Professionals Follow-Up Study. Spearman's correlation coefficients (r) intraclass (ICCs) used assess agreement between (1) 42 triplicate...
<h3>Importance</h3> Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether reduction extends beyond that provided by pregnancy alone or differs histotype is unclear. Furthermore, the observed associations between duration and timing breastfeeding have inconsistent. <h3>Objective</h3> To determine association (ie, ever/never, duration, timing) overall histotype. <h3>Design, Setting, Participants</h3> A...
OBJECTIVE: To investigate the relationship between endometriosis and adverse pregnancy outcomes. METHODS: Women ages 25 42 years in 1989 (n=116,429) reported detailed information on pregnancies reproductive health at baseline every 2 thereafter Nurses' Health Study II, a cohort study. In 2009, they completed detailed, pregnancy-focused questionnaire. A total of 196,722 were reported. Adverse outcomes included spontaneous abortion, ectopic pregnancy, stillbirth, gestational diabetes mellitus...
Abstract Purpose: A major challenge in platinum-based cancer therapy is the clinical management of chemoresistant tumors, which have a largely unknown pathogenesis at level epigenetic regulation. Experimental Design: We evaluated potential using global loss 5-hydroxymethylcytosine (5-hmC) levels as novel diagnostic and prognostic marker to better assess chemotherapy response outcome high-grade serous tumors (HGSOC), most common deadliest subtype ovarian cancer. Furthermore, we identified...
To assess the effect of dienogest on recurrence ovarian endometriomas and severity pain after laparoscopic surgery, a retrospective study 81 patients was performed at three institutions in Osaka, Japan. Patients had six-month minimum follow-up surgery for between June 2012 August 2014. who chose to receive 2 mg daily those were managed expectantly postoperatively included. Recurrence defined as presence more than cm. A visual analog scale (VAS) used score intensity pelvic pain. The...
Abstract Introduction Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder affecting salivary and lacrimal glands, while endometriosis involves uterine‐like tissue growth outside the uterus, causing pelvic pain infertility. Investigating their intricate relationship using real‐world data crucial due to limited research on connection. Material Methods This population‐based cohort study included patients with controls without endometriosis. Propensity score matching was used...
Introduction Over four million women in the US alone have been diagnosed with endometriosis. For those living this disease, surgery and hormonal treatment reduce associated pelvic pain some, while others continue to experience life impacting pain. Therefore, identification of accessible cost-effective methods reduction compliment current is urgently needed. Our objective was quantify prevalence complementary alternative used manage acyclic their reported benefit among different age groups...
Abstract Background: Parity and breastfeeding are associated with systemic changes in maternal inflammation reduced risk of ovarian cancer, but little is known about their impact on the tumor immune microenvironment. Methods: We evaluated associations self-reported parity history tumor-infiltrating T cells among 1,706 carcinoma cases tissue collected across four studies. The abundance was measured by multiplex immunofluorescence microarrays. Odds ratios (OR) 95% confidence intervals (CIs)...
Abstract Background: Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology of HGSC. We investigated between different epidemiologic factors and HGSC subtypes. Methods: pooled data from 11 case-control studies tumor gene custom NanoString CodeSets developed through a collaboration within Tumor Tissue Analysis Consortium....
Background Conditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pathways. However, there wide variation in the CPM response described literature and ongoing debate about its utility. Methods Here we explored women with ( n = 59) without 26) chronic pelvic (CPP), aiming to determine magnitude of effect factors influencing variability response. Results Using pressure threshold test stimulus ischaemic cuff conditioning (CS), found no significant difference...
What are the plasma metabolomics profiles associated with endometriosis in adolescents and young adults? Our findings show dysregulation of metabolomic adults endometriosis, revealing systemic elevation fatty acyls ceramides cases compared to controls. Endometriosis is a gynecologic disease often presenting severe pelvic pain impacting around 200 million reproductive-aged women worldwide. However, little known about pathophysiology molecular features diagnosed during adolescence adulthood....
Abstract STUDY QUESTION What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults? SUMMARY ANSWER Significant enrichment increased activation proteins related to angiogenesis cell migration pathways were observed cases compared controls (P-value &lt; 2.4 × 10−8). WHAT IS KNOWN ALREADY Little is known about pathophysiology adolescent despite fact that over 50% adults with report onset severe pelvic pain during adolescence. DESIGN, SIZE, DURATION A...
Abstract We described trends in pelvic pain characteristics over 2 years of follow-up among adolescents and adults with without endometriosis participating the longitudinal observational cohort Women's Health Study: From Adolescence to Adulthood, using data reported at baseline 1 follow-up. Participants completed a questionnaire (between November 2012 May 2019) annually thereafter that included validated measures severity, frequency, life interference dysmenorrhea, acyclic pain, dyspareunia....
Abstract Chronic pelvic pain is heterogeneous with potentially clinically informative subgroups. We aimed to identify subgroups of based on symptom patterns and investigate their associations inflammatory chronic pain-related comorbidities. Latent class analysis (LCA) identified participants (n = 1255) from the Adolescence Adulthood (A2A) cohort. Six participant characteristics were included in LCA: severity, frequency, impact daily activities both menstruation-associated (cyclic)...
Endometriosis is a painful gynecologic disease affecting one in ten reproductive aged women worldwide. Few studies have correlated this symptomatology with biomarker levels among and without endometriosis, no correlating pain been performed young patient populations. The purpose of study was to examine whether CA125 correlates different types severity adolescents endometriosis assess its performance as an those presenting dysmenorrhea population. Reproductive-aged laparoscopically-confirmed...
Abstract STUDY QUESTION What are the similarities and differences in systemic proteomic profiles by endometriosis-associated pain subtypes among adolescents young adults with endometriosis? SUMMARY ANSWER Endometriosis-associated exhibited distinct plasma profiles. WHAT IS KNOWN ALREADY Endometriosis patients, especially those diagnosed adults, often plagued various symptoms. However, it is not clear what biological processes underlie this heterogeneity. DESIGN, SIZE, DURATION We conducted a...
Summary: Biological characteristics of tumors are heterogeneous, forming spectra in terms several factors such as age at onset, anatomic spatial localization, tumor subtyping, and the degree aggressiveness (encompassing a neoplastic property spectrum). Instead blindly using dichotomized approaches, application multicategorical continuous analysis approaches to detailed cancer spectrum data can contribute better understanding etiology cancer, ultimately leading effective prevention precision...
Abstract Background Tea and coffee are the most frequently consumed beverages in world. Green tea particular contains compounds with potential anti-cancer effects, but its association survival after ovarian cancer is uncertain. Methods We investigated associations between consumption before diagnosis using data from 10 studies Ovarian Cancer Association Consortium. Data on (green, black, herbal), caffeine intake were available for up to 5724 women. used Cox proportional hazards regression...