A5076818447- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Inflammatory mediators and NSAID effects
- Nutrition, Genetics, and Disease
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Cancer-related gene regulation
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Immune cells in cancer
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Broad Institute
2016-2025
Tokyo Medical and Dental University
2024-2025
Dana-Farber/Harvard Cancer Center
2012-2025
Dana-Farber Cancer Institute
2015-2024
Massachusetts Institute of Technology
2016-2024
Massachusetts General Hospital
2009-2024
Beth Israel Deaconess Medical Center
2009-2024
The University of Texas MD Anderson Cancer Center
2000-2024
The tumor microenvironment of colorectal carcinoma is a complex community genomically altered cancer cells, nonneoplastic and diverse collection microorganisms. Each these components may contribute to carcinogenesis; however, the role microbiota least well understood. We have characterized composition in using whole genome sequences from nine tumor/normal pairs. Fusobacterium were enriched carcinomas, confirmed by quantitative PCR 16S rDNA sequence analysis 95 carcinoma/normal DNA pairs,...
Colonoscopy and sigmoidoscopy provide protection against colorectal cancer, but the magnitude duration of protection, particularly cancer proximal colon, remain uncertain.We examined association use lower endoscopy (updated biennially from 1988 through 2008) with colorectal-cancer incidence (through June 2010) mortality 2012) among participants in Nurses' Health Study Professionals Follow-up Study.Among 88,902 followed over a period 22 years, we documented 1815 incident cancers 474 deaths...
Bacteria go the distance in cancer The bacterial species Fusobacterium nucleatum is associated with a subset of human colorectal cancers, but its role tumorigenesis unclear. Studying patient samples, Bullman et al. found that F. and certain co-occurring bacteria were present not only primary tumors also distant metastases. Preliminary evidence suggests bacterium localized primarily within metastatic cells rather than stroma. Antibiotic treatment mice carrying xenografts –positive slowed...
Serrated lesions of the colorectum are precursors perhaps one-third colorectal cancers (CRCs). Cancers arising in serrated usually proximal colon, and account for a disproportionate fraction cancer identified after colonoscopy. We sought to provide guidance clinical management based on current evidence expert opinion regarding definitions, classification, significance lesions. A consensus conference was held over 2 days reviewing topic from perspectives histology, molecular biology,...
<h3>Objective</h3> Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. <i>Fusobacterium nucleatum</i> may promote tumour growth inhibit T cell-mediated immune responses against tumours. Thus, we hypothesised that amount of <i>F. in carcinoma might be associated with worse clinical outcome. <h3>Design</h3> We used molecular pathological epidemiology database 1069 rectal colon cancer cases Nurses' Health Study Professionals Follow-up Study, measured DNA tissue....
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, survival data. identified recurrently mutated genes in CRC, such as BCL9L, RBM10, CTCF, KLF5, that were not previously appreciated this disease. Furthermore, we investigated correlates immune-cell infiltration found higher neoantigen...
Regular use of aspirin after a diagnosis colon cancer has been associated with superior clinical outcome. Experimental evidence suggests that inhibition prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by down-regulates phosphatidylinositol 3-kinase (PI3K) signaling activity. We hypothesized the effect on survival and prognosis in patients cancers characterized mutated PIK3CA (the phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit alpha...
<h3>Background:</h3> The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with microsatellite instability (MSI) and <i>BRAF</i> mutation in colorectal cancer. independent effect of CIMP, MSI on prognosis remains uncertain. <h3>Methods:</h3> Utilising 649 colon cancers (stage I–IV) two cohort studies, we quantified DNA methylation eight CIMP-specific promoters (<i>CACNA1G, CDKN2A</i> (p16), <i>CRABP1, IGF2, MLH1</i>, <i>NEUROG1, RUNX3</i>...
Regular use of aspirin reduces the risk a colorectal neoplasm, but mechanism by which affects carcinogenesis in colon is not well understood.
Numerous longevity genes have been discovered in model organisms and altering their function results prolonged lifespan. In mammals, some speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of propensity to boost cell survival. The Sir2/SIRT1 family NAD+-dependent deacetylases is proposed underlie the calorie restriction (CR), a diet broadly suppresses mammals. Here we show CR induces two-fold increase SIRT1...
Colorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic epigenetic features differ by tumour location. Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that molecular might gradually change along subsites, rather than abruptly at splenic flexure.Utilising 1443 colorectal cancers two US nationwide prospective cohort studies, the frequencies (CpG island methylator phenotype...
Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota immunity for colorectal cancer prevention therapy, better understanding of relationship microorganisms immune cells in tumor microenvironment is needed. Experimental evidence suggests that Fusobacterium nucleatum may promote colonic neoplasia development by downregulating antitumor T cell-mediated adaptive immunity.To test hypothesis greater amount F carcinoma tissue...
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal and adjacent normal tissues of 28 MMRp 34 MMRd individuals. Analysis 88 cell subsets their 204 associated gene expression programs revealed extensive transcriptional spatial remodeling across discover hubs...
Abstract To understand the genetic drivers of immune recognition and evasion in colorectal cancer, we analyzed 1,211 cancer primary tumor samples, including 179 classified as microsatellite instability–high (MSI-high). This set includes The Cancer Genome Atlas cohort 592 completed here. MSI-high, a hypermutated, immunogenic subtype had high rate significantly mutated genes important immune-modulating pathways antigen presentation machinery, biallelic losses B2M HLA due to copy-number...