William Ge
A5002886528- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Ovarian cancer diagnosis and treatment
- Dental Health and Care Utilization
- Child and Adolescent Health
- Cancer Immunotherapy and Biomarkers
- Animal Genetics and Reproduction
- Adolescent and Pediatric Healthcare
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- CRISPR and Genetic Engineering
- Colorectal Cancer Treatments and Studies
- Innovations in Medical Education
- Colorectal Cancer Screening and Detection
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Extracellular vesicles in disease
- Pediatric health and respiratory diseases
- Prostate Cancer Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Biological Research and Disease Studies
- Ferroptosis and cancer prognosis
- Intergenerational Family Dynamics and Caregiving
Dana-Farber Cancer Institute
2022-2024
Harvard University
2021-2024
Northwell Health
2018-2022
Broad Institute
2019-2021
Massachusetts Institute of Technology
2021
Yale University
2016-2020
Cohen Children's Medical Center
2018-2019
Schneider Children's Hospital
2018
National Institutes of Health
2014
Moffitt Cancer Center
2011
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal and adjacent normal tissues of 28 MMRp 34 MMRd individuals. Analysis 88 cell subsets their 204 associated gene expression programs revealed extensive transcriptional spatial remodeling across discover hubs...
ABSTRACT A multitude of single-cell RNA sequencing methods have been developed in recent years, with dramatic advances scale and power, enabling major discoveries large cell mapping efforts. However, these not systematically comprehensively benchmarked. Here, we directly compare seven for single and/or nucleus profiling from three types samples – lines, peripheral blood mononuclear cells brain tissue generating 36 libraries six separate experiments a center. To analyze datasets, applied...
Lipid raft membrane microdomains organize signaling by many prototypical receptors, including the Toll-like receptors (TLRs) of innate immune system. Raft-localization proteins is widely thought to be regulated cholesterol levels, but this largely on basis studies that have manipulated cell using crude and poorly specific chemical tools, such as β-cyclodextrins. To date, there has been no proteome-scale investigation whether endogenous regulators intracellular trafficking, ATP binding...
The introduction of immune checkpoint blockade (ICB) has markedly improved outcomes for advanced melanoma. However, many patients develop resistance through unknown mechanisms. While combination ICB response rate and progression-free survival, it substantially increases toxicity. Biomarkers to distinguish who would benefit from therapy versus aPD-1 remain elusive. We analyzed whole-exome sequencing pretreatment tumors four cohorts ( n = 140) ICB-naïve treated with aPD-1. High genomic...
Infecting 90% of the global population, HSV-1 and HSV-2 represent some most prevalent viruses in world. Much their success can be attributed to ability establish lifelong latent infections dorsal root ganglia (DRG). It is still largely unknown, however, how host transcription factors are involved establishing this latency. Here, we report that RUNX1, expressed highly DRG, binds genome, represses numerous viral genes, suppresses productive vitro infection. Our computational work further...
Plan checks are important components of a robust quality assurance (QA) program. Recently, the American Association Physicists in Medicine (AAPM) published two reports concerning plan and chart checking, Task Group (TG) 275 Medical Physics Practice Guideline (MPPG) 11.A. The purpose current study was to crosswalk initial check failure modes revealed TG against our institutional QA program local incident reporting data. Ten physicists reviewed 46 high-risk reported Table S1.A.i report....
Abstract While the introduction of immune checkpoint blockade (ICB) has dramatically improved clinical outcomes for patients with advanced melanoma, a significant proportion develop resistance to therapy, and mechanisms are poorly elucidated in most cases. Further, while combination ICB higher response rates progression free survival compared single agent therapy front line setting, there is significantly increased toxicity ICB, biomarkers identify who would disproportionately benefit from...
This commentary highlights the risks and benefits associated with an increasingly popular video game format, augmented-reality (ARG). ARGs are different from typical games in that they combine live views of real world computer generated into one interface. Despite recent popularity ARG particular, Pokemon GO, relatively little information has yet been provided to pediatricians parents about dangers can offer children. article aims illuminate potential harms this type order best protect...
Abstract Background: Despite significant advances, only a subset of patients with advanced melanoma treated immune checkpoint blockade (ICB) experience durable responses, and biomarkers to predict response are limited. Further, while combination ICB has higher rates improved progression-free survival compared single-agent therapy in the front-line setting, there is significantly increased toxicity ICB, identify who would disproportionately benefit from vs aPD-1 poorly characterized. Methods:...
Abstract Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal and adjacent normal tissues of 28 MMRp 34 MMRd patients. Analysis 88 cell subsets their 204 associated gene expression programs revealed extensive transcriptional spatial remodeling across discover hubs...
Supplementary Figure S1 from <i>LIN28B</i> Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer