A5046689115- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Analytical chemistry methods development
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Nephrotoxicity and Medicinal Plants
- Photoreceptor and optogenetics research
- Origins and Evolution of Life
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Electrochemical Analysis and Applications
- Pharmacogenetics and Drug Metabolism
- Biochemical Analysis and Sensing Techniques
- Polyamine Metabolism and Applications
- Microbial Metabolic Engineering and Bioproduction
- DNA Repair Mechanisms
- Pesticide Residue Analysis and Safety
- Advanced Proteomics Techniques and Applications
- Bacterial biofilms and quorum sensing
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Water Treatment and Disinfection
- Carcinogens and Genotoxicity Assessment
University of Duisburg-Essen
2016-2025
Petra University
2016
Paderborn University
2016
University of Wuppertal
2006-2015
Dutch Polymer Institute
2009
University of Cologne
2009
Royal Bournemouth Hospital
2005
German Cancer Research Center
2000-2004
DKFZ-ZMBH Alliance
2000-2004
Heidelberg University
2000-2001
SUMMARY The phenotype of an organism is determined by the genes, environment and stochastic developmental events. Although recognized as a basic biological principle influencing life history, susceptibility to diseases, probably evolution, variation (DV) has been only poorly investigated due lack suitable model organism. This obstacle could be overcome using recently detected, robust highly fecund parthenogenetic marbled crayfish experimental animal. Batch-mates this clonal crayfish, which...
Collision cross section (CCS, Ω) values determined by ion mobility mass spectrometry (IM-MS) provide the study of shape in gas phase and use these as further identification criteria analytical approaches. Databases CCS for a variety molecules different instrument types are available. In this study, comparability drift tube spectrometer (DTIM-MS) traveling wave (TWIM-MS) was investigated to test if common database could be used across IM techniques. A total 124 substances were measured with...
Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of selected lipids under various biological conditions but comprehensive software tools to support such analyses are lacking. Here we present LipidCreator, a that fully supports assay development. LipidCreator offers framework compute MS/MS fragment masses for over 60 lipid classes. provides all functionalities needed define fragments, manage stable isotope labeling, optimize collision energy and generate in...
Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[ a ]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs). In order to evaluate the role of hepatic versus extra-hepatic metabolism BaP its pharmacokinetics, we used P450 reductase null (HRN) mouse model, in which oxidoreductase, unique electron donor CYPs, is deleted specifically hepatocytes, resulting loss essentially all CYP function. HRN...
Novel stationary phases have been emerging recently. A β-alanine-derived embedded urea and amide group-containing C18 phase (Sil-Ala-C18) was prepared for the first time. The media were packed into a 150 × 2.1 mm HPLC column, newly designed column evaluated with Tanaka Neue test protocols in reversed-phase liquid chromatography (RPLC) separation mode. Moreover, it characterized by protocol hydrophilic interaction (HILIC) new elemental analysis, attenuated total reflectance Fourier transform...
Pentafluorophenyl (PFP) stationary phase is one of the most important phases after C18 in terms its applications. Three embedded polar groups (EPG)-containing were newly synthesized to act EPGs as additional interaction sites. The silica surface was initially modified with (3-aminopropyl)trimethoxysilane (APS). APS-modified silicas coupled 2,3,4,5,6-pentafluorobenzoic acid, 2,3,4,5,6-pentafluorophenylacetic and 2,3,4,5,6-pentafluoro-anilino(oxo)acetic acid obtain Sil-PFP-BA, Sil-PFP-AA,...
Abstract We report on the development of a new laser‐ionization (LI) source operating at atmospheric pressure (AP) for liquid chromatography/mass spectrometry (LC/MS) applications. APLI is introduced as powerful addition to existing AP ionization techniques, in particular atmospheric‐pressure chemical (APCI), electrospray (ESI), and photoionization (APPI). Replacing one‐step VUV approach APPI with step‐wise two‐photon strongly enhances selectivity process. Furthermore, photon flux during an...
Abstract We report on the structural design and characterization of a series neutral heteroleptic iridium(III) complexes equipped with 2‐phenylpyridine, 2‐(naphthalen‐1‐yl)pyridine, 1‐phenylisoquinoline as cyclometalating ligands. To gradually increase unsymmetrical architecture complexes, they have been furnished 2,2,6,6‐tetramethylheptane‐3,5‐dione, 1‐(9 H ‐carbazol‐9‐yl)‐5,5‐dimethylhexane‐2,4‐dione, 1‐[3,6‐bis(4‐hexylphenyl)‐9 ‐carbazol‐9‐yl]‐5,5‐dimethylhexane‐2,4‐dione ancillary The...
Recently we introduced atmospheric pressure laser ionization (APLI) as a complementary method for coupling LC-MS systems (HPLC and CEC), allowing of nonpolar aromatic compounds via near-resonant two-photon excitation. In this paper, demonstrate that APLI with the same source enclosure LC is also suited hyphenation GC atmospheric-pressure mass spectrometry. This technique permits qualitative quantitative determination in an ultralow concentration range, show here polycyclic hydrocarbons...
The efficient synthesis of novel beta-diketonates equipped with functional carbazolyl moieties and their subsequent transformations in 5-hexyl-thienyl substituted carbazole derivatives is presented by utilizing an effective Stille cross-coupling reaction. introduced served as ancillary ligands for heteroleptic red- green-emitting Ir(III) complexes, when combined 2-(naphthalen-1-yl)pyridine 2-phenylpyridine cyclometalating ligands. These complexes revealed color-tunability a very good thermal...
Bitterness and pungency are important parameters for olive oil quality. Therefore, two instrumental methods evaluation of these taste attributes were developed. The first one is based on the photometric measurement total phenolic compounds content, whereas second semiquantitative hydrophilic by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Evaluation content was performed a modified method determination K(225) value using more specific detection pH dependency absorbance...