A5034188143- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Pharmacogenetics and Drug Metabolism
- Plant Pathogens and Fungal Diseases
- DNA and Nucleic Acid Chemistry
- Estrogen and related hormone effects
- Nephrotoxicity and Medicinal Plants
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related Molecular Pathways
- Glutathione Transferases and Polymorphisms
- Forest Insect Ecology and Management
- Drug Transport and Resistance Mechanisms
- Health, Environment, Cognitive Aging
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Plant Pathogens and Resistance
- Genetically Modified Organisms Research
- Atomic and Subatomic Physics Research
- Heavy Metals in Plants
- Yeasts and Rust Fungi Studies
- Chemical Reactions and Isotopes
- Synthesis and Biological Evaluation
King's College London
2015-2025
Office of Naval Research
2024
University of New Mexico
2024
The Ohio State University
2018-2023
Centre International de Recherche sur le Cancer
2005-2023
Public Health England
2016-2020
Imperial College London
1993-2020
Institute of Cancer Research
2006-2018
MRC Centre for Environment and Health
2014-2018
The Francis Crick Institute
2016-2018
Tobacco smoking increases the risk of at least 17 classes human cancer. We analyzed somatic mutations and DNA methylation in 5243 cancers types for which tobacco confers an elevated risk. Smoking is associated with increased mutation burdens multiple distinct mutational signatures, contribute to different extents cancers. One these mainly found derived from tissues directly exposed smoke, attributable misreplication damage caused by carcinogens. Others likely reflect indirect activation...
Highlights•41 of 79 environmental agents yielded substitution signatures•6 produced double-substitution signatures and 8 indel signatures•Several match or exhibit similarity with found in human tumors•Topographical mutational asymmetries reveal mechanistic insightsSummaryWhole-genome-sequencing (WGS) tumors has revealed distinct mutation patterns that hint at the causative origins cancer. We examined 324 WGS human-induced pluripotent stem cells exposed to known suspected carcinogens....
Lung cancer is a leading cause of mortality with an inter-individual difference in susceptibility to the disease. The inheritance low-efficiency genotypes involved DNA repair and replication may contribute susceptibility. We investigated 44 single nucleotide polymorphisms (SNPs) 20 genes including excision (NER) XPA , ERCC1 ERCC2/XPD ERCC4/XPF ERCC5/XPG; base (BER) APE1 / APEX OGG1 MPG XRCC1 PCNA POLB POLι LIG3 EXO1; double-strand break (DSB-R) XRCC2 XRCC3 XRCC9 NBS1 ATR; direct damage...
EXPOsOMICS is a European Union funded project that aims to develop novel approach the assessment of exposure high priority environmental pollutants, by characterizing external and internal components exposome. It focuses on air water contaminants during critical periods life. To this end, centres 1) at personal population levels within existing short long-term studies, exploiting available tools methods which have been developed for monitoring (PEM); 2) multiple "omic" technologies analysis...
Whole genome sequencing of human tumours has revealed distinct patterns mutation that hint at the causative origins cancer. Experimental investigations mutations and spectra induced by environmental mutagens have traditionally focused on single genes. With advent faster cheaper platforms, it is now possible to assess in experimental models across whole genome. As a proof principle, we examined profiles mouse embryo fibroblasts immortalised following exposure benzo[a]pyrene (BaP), ultraviolet...
Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron copper, respectively, produce oxidative stress increase risk liver cancer. Because frequency p53 mutated alleles in nontumorous human tissue may be a biomarker oxyradical damage identify individuals at increased cancer risk, we have determined from WD hemochromatosis patients. When compared with samples normal controls, higher frequencies G:C to T:A transversions codon 249 (P < 0.001) C:G A:T...
Background Larvae of the greenbottle fly Lucilia sericata are used routinely for clinical treatment difficult necrotic and infected wounds. Degradation by proteinases contained in larval excretory/secretory (ES) products is thought to contribute wound debridement removal dead tissue. However, proteinase activity may also affect host tissue remodelling processes. Objectives To identify proteolytic enzymes derived from L. ES with activities against fibrin extracellular matrix (ECM) components....
Journal Article Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 C57BL/6 mice human MCL-5 cells Get access Ian N.H. White, White Search for other works by this author on: Oxford Academic PubMed Google Scholar Francesco de Matteis, Matteis Adrian Davies, Davies Lewis L. Smith, Smith Christopher Crofton-Sleigh, Crofton-Sleigh 1Haddow Laboratories, Institute Cancer ResearchCotswold Road, Sutton, Surrey, SM2 5NG, UK Stanley Venitt, Venitt Alan Hewer, Hewer...
Journal Article 32 P-Post-labelling analysis of DNA adducts formed in the livers animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F 1 mice Get access David H. Phillips, Phillips Search for works by this author on: Oxford Academic PubMed Google Scholar M. Vijayaraj Reddy, Reddy 1Department Pharmacology, Baylor College MedicineHouston, TX 77030, USA Kurt Randerath Carcinogenesis, Volume 5, Issue 12, December 1984, Pages 1623–1628,...
The aim of this project was to devise and test improved protocols the 32P-postlabelling assay for detection carcinogen-DNA adducts. intention reverse drift different investigators using increasingly divergent experimental conditions. This would lead a more standardized that can be used in future applications by monitoring human exposure genotoxic agents, permitting meaningful comparisons between studies or participants same study. As part process, there perceived need carcinogen-modified DNA...