A5089599573- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Melanoma and MAPK Pathways
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Photoacoustic and Ultrasonic Imaging
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- Inflammatory mediators and NSAID effects
Duke University
2019-2025
Allen Institute
2017-2025
Koch Institute for Integrative Cancer Research At MIT
2015-2025
Massachusetts Institute of Technology
1927-2023
University Gastroenterology
2019-2023
Durham VA Medical Center
2022
Duke University Hospital
2020
Tufts Medical Center
2011-2019
Molecular Oncology (United States)
2014-2019
Tufts University
2011-2018
Getting all stressed out by vitamin C Few experimental cancer therapies have incited as much debate C. Yet the mechanistic effect of on cells is still poorly understood. Yun et al. studied human colorectal with KRAS or BRAF mutations and found that they “handle” in a different way than other cells, ultimately to their detriment (see Perspective Reczek Chandel). Because certain receptor up-regulated mutant take up oxidized form (dehydroascorbate). This leads oxidative stress, inactivation...
The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) Kras
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated obesity and an increased risk colorectal cancer. Whether HFCS contributes directly to tumorigenesis unclear. We investigated the effects daily oral administration in adenomatous polyposis coli (APC) mutant mice, which are predisposed develop intestinal tumors. The HFCS-treated mice showed a substantial increase tumor size grade absence metabolic syndrome. concentrations fructose glucose lumen...
Purpose To examine the in vitro and vivo efficacy of dual PI3K/mTOR inhibitor NVP-BEZ235 treatment PIK3CA wild-type colorectal cancer (CRC). Experimental Design mutant human CRC cell lines were treated with NVP-BEZ235, resulting effects on proliferation, apoptosis, signaling assessed. Colonic tumors from a genetically engineered mouse (GEM) model for sporadic NVP-BEZ235. The macroscopic tumor growth/regression, angiogenesis, examined. Results In resulted transient PI3K blockade, sustained...
Abstract Colorectal cancers harboring KRAS or BRAF mutations are refractory to current targeted therapies. Using data from a high-throughput drug screen, we have developed novel therapeutic strategy that targets the apoptotic machinery using BCL-2 family inhibitor ABT-263 (navitoclax) in combination with TORC1/2 inhibitor, AZD8055. This leads efficient apoptosis specifically KRAS- and BRAF-mutant but not wild-type (WT) colorectal cancer cells. specific susceptibility results inhibition...
Appetite and energy expenditure are regulated in part by ghrelin leptin produced the gastric mucosa, which may be modified H. pylori colonization. We prospectively evaluated effect of eradication on meal-associated changes serum levels, body weight. Veterans referred for upper GI endoscopy were at baseline ≥8 weeks after endoscopy, status weight ascertained. During first visit all subjects, during subsequent visits initially pylori-positive subjects controls, blood was collected an overnight...
Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant with worst outcomes. This CRC subtype is associated activating mutations in mitogen-activated kinase pathway gene, BRAF , epigenetic modifications termed CpG Island Methylator Phenotype, leading to silencing key tumour suppressor genes. It still not clear which (epi-)genetic changes important neoplastic progression we begin address this knowledge...
Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) stool was inversely associated with intestinal tumor burden and IL-1β concentrations mice. Here, we assessed anti-inflammatory capacity Pd membrane fraction (PdMb) colon cancer cell lines. In addition, tested whether could suppress tumorigenesis Six-week-old male A/J mice were fed a low-fat (LF) diet, high-fat (HF) diet or HF+ whole freeze-dried...
Context: Leptin and ghrelin, hormones involved in human energy homeostasis, are both produced the stomach. Objective: We sought to determine whether presence of Helicobacter pylori affects gastric systemic levels leptin ghrelin. Design, Setting, Patients: consecutively enrolled 256 patients referred for upper endoscopy at a Veterans Affairs outpatient center. Outcomes: obtained fasting serum, fundic antral biopsies, juice. Based on histological, biochemical, serological assays, were...
BRAF(V600E) mutations are associated with poor clinical prognosis in colorectal cancer (CRC). Although selective BRAF inhibitors effective for treatment of melanoma, comparable efforts CRC have been disappointing. Here, we investigated potential mechanisms underlying this resistance to CRC.We examined phosphoinositide 3-kinase (PI3K)/mTOR signaling cell lines after inhibition and viability apoptosis combined PI3K/mTOR inhibition. We assessed the efficacy vivo combination using a novel...
Estrogens regulate eosinophilia in asthma and other inflammatory diseases. Further, peripheral tumor-associated tissue (TATE) predicts a better response to immune checkpoint blockade (ICB) breast cancer. However, how if estrogens affect eosinophil biology tumors this influences ICB efficacy has not been determined. Here, we report that decrease the number of eosinophils TATE, contributes increased tumor growth validated murine models cancer melanoma. Moreover, estrogen signaling healthy...
Background: Gastro-oesophageal reflux disease complications may reflect imbalances between protective and injurious factors. Through its effects on cell growth, leptin influence oesophageal mucosal homeostasis. Aims: To determine whether receptors are present in the oesophagus, serum or gastric levels associated with inflammation metaplasia. Methods: From patients referred for upper endoscopy, biopsies were obtained from stomach distal samples collected. Patients classified as having normal,...