A5065746423- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Cancer, Lipids, and Metabolism
- Microfluidic and Bio-sensing Technologies
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Salivary Gland Disorders and Functions
- Advanced Proteomics Techniques and Applications
- Digestive system and related health
- Metastasis and carcinoma case studies
- Renal and related cancers
- Oral health in cancer treatment
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
Dokuz Eylül University
2016-2025
Allen Institute
2019-2024
Stanford University
2015-2023
Massachusetts Institute of Technology
2020-2023
Dokuz Eylül Üniversitesi Hastanesi
2021
University of Health Science
2020
University of Health Sciences
2020
Turkish Thoracic Society
2020
Süleyman Demirel University
2019
Koch Institute for Integrative Cancer Research At MIT
2019
Significance Cells consist of micro- and nanoscale components materials that contribute to their fundamental magnetic density signatures. Previous studies have claimed levitation can only be used measure signatures nonliving materials. Here, we demonstrate both eukaryotic prokaryotic cells levitated each cell has a unique profile. Furthermore, our platform uniquely enables ultrasensitive measurements, imaging, profiling in real-time at single-cell resolution. This method broad applications,...
Abstract Cancer microenvironment is a remarkably heterogeneous composition of cellular and non-cellular components, regulated by both external intrinsic physical chemical stimuli. Physical alterations driven increased proliferation neoplastic cells angiogenesis in the cancer result exposure to elevated levels flow-based shear stress. We developed dynamic microfluidic cell culture platform utilizing eshopagael as model investigate phenotypic changes upon fluid report epithelial hybrid...
The insulin‑like growth factor receptor (IGF‑1R) axis drives cellular growth, survival and chemoresistance in colorectal cancer (CRC) by promoting proliferative signaling, anti‑apoptotic effects epithelial‑mesenchymal transition (EMT). Targeting the IGF‑1R pathway is therefore a promising strategy, not only for overcoming drug resistance, but also reducing migration metastatic behavior related to EMT. present study aimed evaluate potential of picropodophyllin (PPP), selective inhibitor,...
Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship clinicopathological features prognosis. Materials Methods: EGFR exons 18-21 48 specimens of paraffin-embedded tumor tissue from NSCLC were amplified by PCR, followed direct sequencing analysis links Results: detected 18 (42.6%) NSCLC. There 9 cases exon 20, 7 19 2 21. Mutations more frequently observed women (5/7 pts, 71.4%)...
Fluoropyrimidine-based chemotherapy is extensively used for the treatment of solid cancers, including colorectal cancer. However, fluoropyrimidine-driven toxicities are a major problem in management disease. The grade and type depend on demographic factors, but substantial inter-individual variation fluoropyrimidine-related toxicity partly explained by genetic factors. aim this study was to investigate effect dihydropyrimidine dehydrogenase (DPYD), thymidylate synthase (TYMS),...
Accurate assessment of cell stiffness distribution is essential due to the critical role mechanobiology in regulation vital cellular processes like proliferation, adhesion, migration, and motility. Stiffness provides information understanding onset progress various diseases, including metastasis differentiation cancer. Atomic force microscopy optical trapping set gold standard measurements. However, their widespread use has been hampered with long processing times, unreliable contact point...
Purpose: Collagen is a critical extracellular matrix (ECM) component that significantly influences cellular behaviors such as adhesion, migration, and proliferation. Optimizing collagen coating protocols essential for developing accurate in vitro models, particularly studying vascular smooth muscle cells (HVSMCs). The aim of this study was to optimize models using HVSMCs by assessing cell morphology, adhesion potential, viability under various concentrations incubation conditions. Methods:...
Nanomedicine has provided promising tools for the imaging, diagnosis, and treatment of cancer. Gold nanoparticles (GNPs) may be useful in enhancing efficacy radiotherapy, such as radiosensitization, cancer therapy. To develop a nanodrug complex containing cetuximab (C225,CTX) cisplatin (CDDP) conjugated with GNPs to investigate its cytotoxic effects on oral cavity cells when combined radiotherapy. In vitro cell culture study. The were synthesized successfully cisplatin. Cell viability was...
5-Fluorouracil (5-FU), the mainstay of solid tumor chemotherapy over past 40 years, induces grade III-IV toxicities in up to 15% patients with polymorphisms dihydropyrimidine dehydrogenase (DPYD), thymidylate synthase (TYMS), and methylenetetrahydrofolate reductase (MTHFR) genes. These include mucositis, neutropenia, nausea, diarrhea, myelosuppression, hand-foot syndrome, rare ocular adverse effects. Here, we present case a female patient rectal cancer who received 5-FU-based developed III...
The prognostic value of KRAS and BRAF mutation in colorectal cancer (CRC) is very consistent. Several studies have demonstrated an association between these gene mutations resistance to anti-EGFR based therapies. Wild type required for a response CRC therapy. aim this study identify the frequency series Turkish patients evaluate relationship demographic features population. were analyzed 220 tumor tissues. assays performed with genomic DNA using automated microarray-based genotyping...
The aim of the study was in-silico drug-likeness analysis, absorption, distribution, metabolism, and excretion (ADME) properties, molecular docking studies anthocyanins as natural anticancer compounds against acting receptor-like kinase 5 (ALK5) receptor. Transforming growth factor-β (TGF-β) plays an essential role in various cellular processes. Increased expression TGF-β its receptor TGFβR-I (i.e. ALK5) have been associated with poor prognosis cancer patients.The activity performed using...
Colorectal cancer has a heterogeneous nature that is influenced by the tumour site. Many improvements have been made in identifying and characterizing genetic alterations between colon rectal cancers. However, there not enough information about KRAS mutational differences rectosigmoid cancers arising elsewhere large bowel. The aim of this study was to determine frequency cancers.Eighty-four patients diagnosed with colorectal were included study. Genomic DNA extracted from formalin-fixed...
Exhaled breath is a source of volatile and nonvolatile biomarkers in the body that can be accessed non-invasively used for monitoring. The collection lung secretions by conventional methods such as bronchoalveolar lavage, induced sputum collection, core biopsies limited invasive nature these methods. Non-invasive exhaled condensate (EBC) provides fluid samples are representative airway lining fluids. Various detected condensates, H2O2, nitric oxide, lipid mediators, cytokines, chemokines,...
Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in KIT gene, which can be used as a prognostic marker for biological behavior tumors, predictive response tyrosine kinase inhibitors, and diagnostic marker. Researchers focused on PDGFRA because both their potential DOG1 positivity diagnosis GISTs. The aim this study is to investigate effect DOG1, , prediction outcome GIST management. Polymerase chain reaction was performed gene exons 9, 11, 13, 17 12 18 with...
Treatment of colorectal peritoneal metastases with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is still evolving. Conducting a randomized trial challenging due to the high heterogeneity in presentation disease various surgical approaches. Biological research may facilitate more rapid translation information into clinical practice. There an emerging need for preclinical model improve HIPEC treatment protocols terms drug doses durations. The aim study design...
Epidermal growth factor receptor (EGFR) mutations are potential markers driving carcinogenesis, and may alter the response to EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). The frequency of NSCLC differs according sex, smoking habits regional-based ethnicity differences. aim present study was determine Turkish highlight importance regional differences, their associations patient characteristics. Genomic DNA extracted from formalin-fixed paraffin-embedded...
Biological invasion is the successful spread and establishment of a species in novel environment that adversely affects biodiversity, ecology, economy. Both invasive non-invasive Caulerpa genus secrete more than thirty different secondary metabolites. Caulerpin one most common metabolites Caulerpa. In this study, caulerpin found cylindracea lentillifera extracts were analyzed, quantified, compared using high-performance thin layer chromatography (HPTLC) for first time. The anticancer...
Background: Epithelial-mesenchymal transition (EMT) plays an important role in the biological and biochemical processes of cells, it is a critical process malignant transformation, mobility cancer. Additionally, EMT one main mechanisms contributing to chemoresistance. Resistance oxaliplatin (OXA) poses momentous challenge chemotherapy advanced colorectal cancer (CRC) patients, highlighting need reverse drug resistance improve patient survival. In this study, we explored response...