A5023263334- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Diet and metabolism studies
- Salivary Gland Disorders and Functions
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Microfluidic and Bio-sensing Technologies
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Nutrition and Health in Aging
- Lung Cancer Diagnosis and Treatment
- Seaweed-derived Bioactive Compounds
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
Dokuz Eylül University
2018-2025
General Department of Preventive Medicine
2023
Süleyman Demirel University
2019
Imperial College London
2019
International University
2019
Cyprus International University
2019
Using CT texture analysis and machine learning methods, this study aims to distinguish the lesions imaged via 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT as metastatic completely responded in patients with known bone metastasis who were previously treated.We retrospectively reviewed 68Ga-PSMA PET/CT images of 75 after treatment, diagnosed prostate cancer had metastasis. A was performed on showing PSMA expression sclerotic without through images....
Abstract Metastatic colorectal cancer (CRC) is still in need of effective treatments. This study applies a holistic approach to propose new targets for treatment primary and liver metastatic CRC investigates their therapeutic potential in-vitro. An integrative analysis samples was implemented alternative target proposals. Integrated microarray were grouped based on co-expression network analysis. Significant gene modules correlated with phenotypes identified. Network clustering pathway...
Background and Purpose Epithelial-to-mesenchymal transition (EMT) enhances the invasive potential of cancers, significantly affecting survival rates in metastatic disease. TGF-β, a potent EMT regulator enriched colon cancer (CRC), is influenced by bioelectric biophysical forces. While some ion channels mechanical forces are linked, TGF-β-coupled mechanosensing mechanisms CRC remain poorly understood. This study investigates mechanosensitive channel TRPV4 its role TGF-β-induced EMT, focusing...
Background and Purpose: Recently, the “Epidermal Growth Factor Receptor” gene its related pathways are potential targets in precision medicine for “Non-Small Cell Lung Cancer” cases. The presented study is a proof of concept study, which utilizes exosomal miRNAs as an easy cheap liquid biopsy approach. We aim to investigate, 4 miRNAs: miR-30b, miR-30c, miR-221-3p, miR-22-3p; miR-1288 control. They defined literature previously. Methods: Thirty-six samples from distinct Non-Small Cancer cases...
The insulin‑like growth factor receptor (IGF‑1R) axis drives cellular growth, survival and chemoresistance in colorectal cancer (CRC) by promoting proliferative signaling, anti‑apoptotic effects epithelial‑mesenchymal transition (EMT). Targeting the IGF‑1R pathway is therefore a promising strategy, not only for overcoming drug resistance, but also reducing migration metastatic behavior related to EMT. present study aimed evaluate potential of picropodophyllin (PPP), selective inhibitor,...
Introduction Lung cancer (LC) is a leading cause of cancer-related mortality worldwide. Approximately 80% LC cases are the non-small cell lung (NSCLC) type, and approximately two-thirds these diagnosed in advanced stages. Only systemic treatment methods can be applied to patients stages when there no chance surgical treatment. Identification mutations that vital importance determining appropriate methods. New noninvasive needed repeat monitor molecular analyses. In this regard, liquid biopsy...
Fluoropyrimidine-based chemotherapy is extensively used for the treatment of solid cancers, including colorectal cancer. However, fluoropyrimidine-driven toxicities are a major problem in management disease. The grade and type depend on demographic factors, but substantial inter-individual variation fluoropyrimidine-related toxicity partly explained by genetic factors. aim this study was to investigate effect dihydropyrimidine dehydrogenase (DPYD), thymidylate synthase (TYMS),...
Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks cancer, has efficient anticancer effects. However, mechanism action is yet be discovered.
Accurate assessment of cell stiffness distribution is essential due to the critical role mechanobiology in regulation vital cellular processes like proliferation, adhesion, migration, and motility. Stiffness provides information understanding onset progress various diseases, including metastasis differentiation cancer. Atomic force microscopy optical trapping set gold standard measurements. However, their widespread use has been hampered with long processing times, unreliable contact point...
Background The diagnostic and prognostic clinical value of circulating tumor DNA (ctDNA) cell-free (cfDNA) in pancreatic malignancies are unclear. Herein, we aimed to perform a meta-analysis evaluate ctDNA cfDNA as potential biomarkers. Methods PRISMA reporting guidelines were followed closely for conducting the current meta-analysis. PubMed/Medline, Scopus, Web Science (WoS) databases scanned detail identify eligible papers study. A quality assessment was performed accordance with REMARK...
It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose this paper was to elucidate Vit-D intake serum 25-hydroxyvitamin-D (25(OH)D) cancer incidence mortality, current evidence in field, biases using meta-meta-analysis method. Meta-analyses focusing intake, 25(OH)D levels, risk/mortality were identified. A structured computer literature search performed PubMed/Medline,...
Nanomedicine has provided promising tools for the imaging, diagnosis, and treatment of cancer. Gold nanoparticles (GNPs) may be useful in enhancing efficacy radiotherapy, such as radiosensitization, cancer therapy. To develop a nanodrug complex containing cetuximab (C225,CTX) cisplatin (CDDP) conjugated with GNPs to investigate its cytotoxic effects on oral cavity cells when combined radiotherapy. In vitro cell culture study. The were synthesized successfully cisplatin. Cell viability was...
One of the most common extracranial solid tumors in childhood is neuroblastoma. In this study, it was aimed to perform a systematic review and meta-analysis evaluate risk neuroblastoma both high low birth weights. The PRISMA MOOSE guidelines were followed during design, analysis, reporting study. A comprehensive literature search undertaken for published papers Embase, PubMed/Medline, Scopus, Web Science (WoS) databases. odds ratio (OR) weight groups, with 95% confidence intervals (CIs),...
Background/aim: Mesenchymal stem cells (MSCs) are a type of adult cell consisting heterogeneous subset stromal that can be isolated from tissues. Folic acid is another important contributor to tissue regeneration and repair, which affects the synthesis some building block molecules used for wound healing. In this study, we examine effect folic MSC-derived soluble factors in healing model.Materials methods: Human umbilical vein endothelial (HUVECs) bone marrow-derived MSCs (BMSCs) were...
Aim. Lung adenocarcinoma is characterized by poor prognosis and short survival rates. Therefore, tools to identify the tumoural molecular structure guide effective diagnosis therapy decisions are essential. Surgical biopsies highly invasive not conducive for patient follow-up. To better understand disease prognosis, novel non-invasive analytic methods needed. The aim of present study genetic mutations in formalin-fixed paraffin-embedded (FFPE) tissue, plasma, exhaled breath condensate (EBC)...