A5049706122- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Biblical Studies and Interpretation
- Jewish and Middle Eastern Studies
- Water Quality and Resources Studies
- Medieval and Classical Philosophy
- Cardiac, Anesthesia and Surgical Outcomes
- Historical and Linguistic Studies
- Hydrology and Watershed Management Studies
- Cancer Immunotherapy and Biomarkers
- Diverticular Disease and Complications
- Archaeology and Natural History
- Metastasis and carcinoma case studies
- Groundwater flow and contamination studies
- Urological Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Archaeology and Historical Studies
- Groundwater and Isotope Geochemistry
- Jewish Identity and Society
- Enhanced Recovery After Surgery
- Pancreatic and Hepatic Oncology Research
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Suzuki (Japan)
2023
Mass General Brigham
2022
University of Pittsburgh Medical Center
2022
MGH Institute of Health Professions
2019-2021
Boston University
2013-2021
Steven Winter Associates (United States)
2016-2020
Yeshiva University
2001-2020
Hebrew Union College - Jewish Institute of Religion
2020
Objective The objectives were to review adult intussusception, its diagnosis, and treatment. Summary Background Data Adult intussusception represents 1% of all bowel obstructions, 5% intussusceptions, 0.003%-0.02% hospital admissions. Intussusception is a different entity in adults than it chlidren. Methods records patients 18 years older with the postoperative diagnosis at Massachusetts General Hospital during 1964 through 1993 reviewed retrospectively. 58 divided into those benign enteric,...
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal and adjacent normal tissues of 28 MMRp 34 MMRd individuals. Analysis 88 cell subsets their 204 associated gene expression programs revealed extensive transcriptional spatial remodeling across discover hubs...
PURPOSE: To evaluate a focused, helical computed tomographic (CT) technique for imaging the appendix in patients suspected of having appendicitis. MATERIALS AND METHODS: One hundred prospectively underwent CT examination, with use oral and colon contrast media contiguous, thin-collimation, right lower quadrant. Results were correlated results surgery pathologic examination from 61 or clinical follow-up 39 patients. RESULTS: scans positive appendicitis 59 patients: true-positive 56 on basis...
Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted.To evaluate the margin-negative (R0) resection rate FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) losartan followed by chemoradiotherapy for cancer.A single-arm phase 2 clinical trial was conducted at large academic hospital from August 22, 2013, to May 2018, among 49 patients previously untreated unresectable as determined...
Abstract Purpose: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require sequencing to tumor-derived mutations facilitate detection, requiring and blood. We evaluated a plasma-only assay integrating genomic epigenomic cancer signatures enable tumor-uninformed detection. Experimental Design: A total 252 prospective serial plasma specimens from 103...
Because of rising costs and shrinking reimbursements, hospitals must continually find ways to improve efficiency productivity. This study attempts increase caseloads in ambulatory surgery operating rooms while maintaining patient satisfaction safety.In most hospitals, patients move through their operative day a linear fashion, starting at registration finishing the recovery room. Given this pattern, only 1 may occupy efforts room team time. By processing parallel throughput are increased...
Screening colonoscopy seemingly decreases colorectal cancer rates in the United States. In addition to removing benign lesions and preventing progression malignancy, screening theoretically identifies asymptomatic patients with early-stage disease, potentially leading higher survival rates.To assess effect of on outcomes colon surgery by reviewing differences staging, disease-free interval, risk recurrence, identify whether diagnosis through improves long-term independent...
Traditionally considered a disease common in the older population, colorectal cancer is increasing incidence among younger demographics. Evidence suggests that populational- and generational-level shifts composition of human gut microbiome may be tied to recent trends gastrointestinal carcinogenesis. This review provides an overview current research putative mechanisms behind rising with insight into future interventions prevent or reverse rate early-onset carcinoma.
In Brief Introduction: Gastrointestinal (GI) complications following heart operation may be life-threatening. Systematic analysis of risk factors to allow early identification patients at for GI complication lead the development strategies mitigate this as well optimize management after its occurrence. Methods: Of 8709 consecutive undergoing during 7 years (1997–2003), 46 (0.53%) developed requiring surgical consultation. Preoperative, intraoperative, and postoperative predictors death were...
Bowel function following surgery for diverticulitis has not previously been systematically described.This study aimed to document the frequency, severity, and predictors of suboptimal bowel in patients who have undergone sigmoid colectomy diverticulitis.This is a retrospective analysis.This was conducted at large, academic medical center.Three hundred twenty-five underwent laparoscopic or open with restoration intestinal continuity were included population. Of these, 249 (76.6%) returned...
In colon cancer, radial margin positivity (RMP) is defined as primary disease involvement at the cut edge of mesentery or nonserosalized portions colon. Although extensively studied for rectal malignancies, RMP has unclear prognostic implications tumors colon.To determine effect on perioperative outcomes well survival and disease-free in cancer.A retrospective cohort study including all patients with surgically treated cancer a tertiary care center from January 1, 2004, through December 31,...
Vascular invasion, in particular extramural venous invasion (EMVI), is a pathologic characteristic that has been extensively studied rectal cancer but rarely colon cancer. This study aims to evaluate its prognostic role stage II-III
Abandoning mandatory angiography in patients with blunt lower-extremity trauma and normal neurovascular examination results does not affect limb salvage.Retrospective, nonrandomized cohort study. Mean follow-up (31 of 52 patients) 9.5 months (range, 0-96 months).Single-institution, academic level I center.Medical records presenting on an emergency basis knee dislocation, distal femoral fractures, or proximal tibial fractures during a 20-year period were reviewed. Fifty-three injuries...
Gavin I. Langmuir's work on the formation and nature of antisemitism has earned him an international reputation. In History, Religion, Antisemitism he bravely confronts problems that arise when historians have to describe explain religious phenomena, as any historian must. How, what extent, can be objective? Is it possible discuss Christian attitudes toward Jews, for example, without adopting historical explanations those whose thoughts actions one is discussing? What, exactly, does mean by...