A5089974611- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Viral Infections and Immunology Research
- Sepsis Diagnosis and Treatment
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Trauma and Emergency Care Studies
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Hip and Femur Fractures
- Enhanced Recovery After Surgery
Deutsches Herzzentrum der Charité
2023-2025
Charité - Universitätsmedizin Berlin
2021-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022-2025
German Centre for Cardiovascular Research
2022-2025
Humboldt-Universität zu Berlin
2023
Freie Universität Berlin
2023
Massachusetts General Hospital
2016-2020
Beth Israel Deaconess Medical Center
2018-2020
Harvard University
2016-2019
Evaluate the dose-response relationship between intraoperative fluid administration and postoperative outcomes in a large cohort of surgical patients.Healthy humans may live state responsiveness without need for supplementation. Goal-directed protocols driven by such measures are limited their ability to define optimal during surgery.This analysis data on file included 92,094 adult patients undergoing noncardiac surgery with endotracheal intubation 2007 2014 at an academic tertiary care...
Background Inflammatory cardiomyopathy is one of the most common causes sudden cardiac death in young adults. Diagnosis inflammatory remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation monitor treatment response. Methods Results A total 233 patients were enrolled, with mean age 45 (±18) years, 105 (45%) women. The primary analysis included 209 adult subjects, whom 66 (32%) diagnosed cardiomyopathy, 17...
Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous studies investigating lactate as a potential prognostic marker have been small inconclusive. In study, it was hypothesised that level (immediately prior to initiation ECPR) clearance (within 24 hours after initiation)...
Postoperative residual neuromuscular blockade continues to be a frequent occurrence with reported incidence rate of up 64%. However, the effect postoperative on health care utilization remains unclear. We conducted retrospective cohort study investigate effects hospital costs (primary outcome), intensive unit admission rate, and length stay (secondary outcomes).
Understanding the clinical features of myocarditis in various age groups is required to identify age-specific disease patterns. The objective this study was examine differences sex distribution and outcomes patients with ages. Patients acute or chronic 3 centers Berlin, Germany from 2005 2021 United States (National Inpatient Sample) 2010 2019 were included. Age examined included "prepubescent" (below 11 years for females below 13 males), adolescents (11 [female] [male] 18 years), young...
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Objectives: Inhalational anesthetics are bronchodilators with immunomodulatory effects. We sought to determine the effect of inhalational anesthetic dose on risk severe postoperative respiratory complications. Design: Prospective analysis data file in surgical cases between January 2007 and December 2015. Setting: Massachusetts General Hospital (tertiary referral center) two affiliated community hospitals. Patients: A total 124,497 adult patients (105,267 study cohort 19,230 validation...
Journal Article Accepted manuscript The Legacy of ECPR - Bridging the Past, Shaping Present, Defining Future Get access Tharusan Thevathasan, Thevathasan Department Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Benjamin Franklin, Berlin, GermanyBerlin Institute Health, GermanyDZHK (German Center for Cardiovascular Research), Germany Search other works by this author on: Oxford Academic Google Scholar Christian Hassager, Hassager...
Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists,...
Abstract Acute pulmonary embolism is a life-threatening condition caused by the thromboembolic obstruction of arteries, which often leads to hemodynamic instability, right ventricular failure, and potentially death. Patients with massive or high-risk PE are particularly vulnerable may not respond conventional treatments, necessitating implementation mechanical circulatory support. Here, we discuss recent advancements in diagnosis multidisciplinary management patients highlight need for rapid...
Abstract Cardiac arrest is a critical emergency in cardiovascular medicine, requiring rapid, multidisciplinary interventions to enhance patient survival and neurological outcomes. This review explores the unique challenges of managing out-of-hospital in-hospital cardiac arrest, with focus on mechanical circulatory support extracorporeal cardiopulmonary resuscitation for selected patients. While management should prioritize rapid transport specialized centers, may allow immediate,...
Objectives: The use of electrocardiograms for predicting significant coronary lesions and mortality in patients with successfully resuscitated out-of-hospital cardiac arrest (OHCA) without ST-segment elevation has not been defined yet. objective this study was to investigate the association predictive value various standardized 12-lead electrocardiogram patterns OHCA no elevations on presence (diagnostic performance) 30-day (prognostic performance). Design: Predefined subanalysis Angiography...
OBJECTIVES: Existing scores for risk stratification after out-of-hospital cardiac arrest (OHCA) are either medically outdated, limited to registry data, small cohorts, and certain healthcare systems only, or include rather complex calculations. The objective of this study was develop an easy-to-use prediction score short-term mortality in patients with successfully resuscitated OHCA without ST-segment elevation on the post-resuscitation electrocardiogram, derived from Angiography...
In this prespecified cohort study, we investigated the influence of postoperative admission to intensive care unit versus surgical ward on health utilization among patients undergoing intermediate-risk surgery.
Recent advances in machine learning provide new possibilities to process and analyse observational patient data predict outcomes. In this paper, we introduce a processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The ability identify high-risk could possibly allow taking pre-emptive measures thus prevent development CS. We mainly focus on techniques imputation missing by generating...
Summary Background Critical care beds are a limited resource, yet research indicates that recommendations for postoperative critical admission based on patient‐level risk stratification not followed. It is unclear how prioritisation decisions made in real‐world settings and the effect of this outcomes. Methods This was prespecified analysis an observational cohort study adult patients undergoing inpatient surgery, conducted 274 hospitals across UK Australasia during 2017. The primary outcome...