A5069649296- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral Infections and Immunology Research
- Parathyroid Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Cardiovascular and exercise physiology
- Renal Transplantation Outcomes and Treatments
- Trauma and Emergency Care Studies
- Cancer-related cognitive impairment studies
- Blood Pressure and Hypertension Studies
- Intensive Care Unit Cognitive Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Treatment and Pharmacology
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Chemical Reactions and Isotopes
- Sarcoidosis and Beryllium Toxicity Research
- Blood transfusion and management
Düsseldorf University Hospital
2019-2025
Heinrich Heine University Düsseldorf
2019-2025
Biolog (United States)
1989
Transcatheter edge-to-edge repair of the mitral valve (M-TEER) is known for its low complication rates. However, optimal level and duration post-procedural care remain unclear. This study aimed to identify specific timeframe complications following M-TEER. We conducted a retrospective analysis 865 patients who underwent M-TEER at University Hospital Düsseldorf between August 2010 2023. Our focused on comprehensive examination all acute (1-100 h), considering time point occurrence or...
Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists,...
Abstract Aims Cancer therapy-related cardiac dysfunction (CTRCD) is a dreaded complication of anthracycline therapy. CTRCD most frequently appears in patients with cardiovascular risk factors (CVR) or known disease. However, limited data exist on incidence and course anthracycline-induced without preexisting factors. We therefore aimed to longitudinally investigate cohort young women treatment due breast cancer disease (NCT03940625). Methods results enrolled 59 primary scheduled...
Purpose: Although a moderate proportion of cardiac arrest (CA) patients achieve return spontaneous circulation (ROSC), few survive to discharge, mostly with poor neurological development. As serum phosphate levels were described as elevated after cardiopulmonary resuscitation (CPR), we asked whether these elevations would predict higher risk mortality and impaired outcome in CA following ROSC. Methods: Initial levels, survival, neurologic status at discharge 488 non-traumatic treated single...
Abstract Background In Europe, more than 300,000 persons per year experience out-of-hospital cardiac arrest (OHCA). Despite medical progress, only few patients survive with good neurological outcome. For many issues, evidence from randomized trials is scarce. OHCA often occurs for causes. Therefore, we established the national, prospective, multicentre German Cardiac Arrest Registry (G-CAR). Herein, describe first results of pilot phase. Results Over a period 16 months, 15 centres included...
Background: The search for the best therapeutic approach in cardiopulmonary resuscitations (CPR) remains open to question. In this study, we evaluated if Amiodarone administration during CPR was associated with short-term mortality or neurological development. Methods: A total of 232 patients sudden cardiac arrest (CA) shockable rhythms were included our analysis. Propensity score matching based on age, gender, type CA, and duration used stratify between without CPR. Primary endpoints...
Abstract Acute kidney injury (AKI) is a common complication post-PCI. Here, in single-center observational registry, we compared the frequency of AKI patients at elevated risk for (based on Mehran stratification scoring) who underwent VA-ECMO- or Impella-supported high-risk PCI. A total 28 scheduled elective PCI with mechanical circulatory support were studied prospectively. All turned down surgery due to exceedingly high risk. Allocation VA-ECMO (n=11) Impella (n=17) was performed according...
Identifying patients who may benefit from mechanical circulatory support (MCS) after out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC) remains challenging; thus, a search for helpful biomarkers is warranted. We aimed to evaluate phosphate lactate levels on admission regarding their associations with survival without MCS.In 224 OHCA achieved ROSC, the initial were investigated discriminate in-hospital mortality by receiver operating characteristic (ROC)...
During circulatory shock, gastrointestinal microcirculation is impaired, especially via activation of the renin-angiotensin-aldosterone system. Therefore, inhibition system might be beneficial in maintaining splanchnic microcirculation. The aim this study was to analyze whether locally applied losartan influences gastric mucosal perfusion (µflow, µvelo) and oxygenation (µHbO 2 ) without systemic hemodynamic changes. In repetitive experiments six anesthetized dogs received 30 mg topically on...
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent myocardial in patients suffering from ischaemic cardiomyopathy (ICM) or dilated (DCM) its association with energy metabolism unknown. We aimed at establishing a relevant role cardiac the impairment production advanced non‐ischaemic HF. Methods included 81 stage D HF (ICM, n = 44; DCM, 37) undergoing left ventricular assist device implantation (...
Abstract Background Despite successful resuscitation with return of spontaneous circulation (ROSC), the prediction survival in patients suffering out‐of‐hospital cardiac arrest (OHCA) remains difficult. Several studies have shown alterations sublingual microcirculation critical ill. We hypothesized that early may predict short‐term after OHCA. Methods prospectively included all adults admitted to our university hospital between April and September 2019 ROSC following Sidestream dark‐field...
Abstract Background Cardiac amyloidosis (CA) is an increasingly recognized cause of human heart failure. Up to 16% patients with severe aortic stenosis (AS) undergoing transcatheter valve replacement have been reported suffer concomitant transthyretin CA (ATTR). Since the diagnosis implies distinct therapies prognostic relevance, early crucial. Different parameters described improve screening accuracy for detection CA, but it unknown whether these are valid, and prevalence stable throughout...
Abstract Background Recent studies suggest that mitral regurgitation (MR) is a dynamic condition influenced by global and regional left ventricular (LV) remodeling as well valvular deformation. Exercise testing plays substantial role in assessing the hemodynamic relevance of MR recommended current guidelines. Handgrip exercise may serve alternative intervention to bicycle exercise, it easy perform even bedside. However, there are no data yet, on prevalence, mechanisms prognostic impact...
Abstract Background Recent randomised controlled trials showed short-term survival benefits with extracorporeal cardiopulmonary resuscitation (ECPR) compared to standard cardiac arrest treatment in selected patients refractory arrest. Only limited data exist on multi-dimensional long-term outcomes after ECPR. Purpose To investigate of ECPR survivors, that is general health status, as well cardiac, cognitive and psychological functions. Methods This a multicenter, mixed-method clinical study...
Abstract Aims Data on the clinical profiles of patients with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) in post‐approval era tafamidis 61 mg are lacking. Study aims were characterization contemporary ATTR‐CM patients, analysis potential eligibility for ‘Transthyretin Amyloidosis Cardiomyopathy Clinical Trial’ (ATTR‐ACT) and identification factors associated decision treatment. Methods results This retrospective study analysed seen at eight University Hospitals first year after...
Abstract Background Bleeding and ischemic complications are the main cause of morbidity mortality in critically ill cardiogenic shock patients, supported by short-term percutaneous mechanical circulatory support (pMCS) devices. Hence, finding optimal antithrombotic regimen is challenging. not only occurs because heparin antiplatelet therapy (both required prevention pump acute stent thrombosis) but also device- disease related coagulopathy. To prevent clotting-related device failure, most...
Percutaneous left ventricular assist devices (pVADs) may be used in patients with cardiogenic shock (CS) to stabilize hemodynamics and maintain sufficient end-organ perfusion. Vascular complications are commonly observed pVAD support. We aimed assess the relationship between implantation time access-site complication rates. This retrospective observational study included all who underwent insertion for treatment of CS at our university hospital 2014 2021 (n = 224). Depending on time, were...
Abstract Background/Introduction In Europe, over 30.000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course OHCA patients warranted. Purpose The German Cardiac Arrest Registry (G-CAR) an observational, prospective,...
Cytomegalovirus (CMV) infections after heart transplantation (HTx) can cause cardiac allograft vasculopathy. Consequently, monitoring and prophylaxis for cytomegalovirus deoxyribonucleic acid (CMV-DNAemia) within the first weeks HTx is recommended.
Objective: Although the application of higher doses norepinephrine (NE) in potential organ donors is a frequent reason for heart decline, its associations with outcomes after transplantation (HTx) are discussed controversially. Therefore, we aimed to explore donor NE support’s impact on our single-center transplant cohort. Methods: All patients who had undergone HTx center between September 2010 and April 2022 (n = 241) were screened eligibility. From those, all complete data support 238)...