A5006670658- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Heart Failure Treatment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholesterol and Lipid Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Cardiovascular Function and Risk Factors
- Magnesium in Health and Disease
- Eicosanoids and Hypertension Pharmacology
- Peripheral Artery Disease Management
- Adipose Tissue and Metabolism
- Syphilis Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Erythropoietin and Anemia Treatment
- Intensive Care Unit Cognitive Disorders
- Adolescent Sexual and Reproductive Health
- Vascular Procedures and Complications
Heinrich Heine University Düsseldorf
2020-2025
Düsseldorf University Hospital
2020-2024
Philipps University of Marburg
2018
Purpose: Early lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a >0% might differ from patients inferior terms of intensive care management outcomes. This study analyzes large collective regards to baseline risk distribution Methods: In total, 3299 were included this analysis, consisting 1528 (46%) ≤0% 1771 (54%) patients. The primary endpoint was unit (ICU) mortality. Multilevel logistic regression analyses used compare...
Abstract Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it may have obscured beneficial properties the activated platelet secretome. We identify platelets as major source a sphingosine-1-phosphate (S1P) burst during AMI, and find its magnitude to favorably associate with cardiovascular mortality infarct size STEMI patients over 12 months. Experimentally, administration supernatant from reduces murine which blunted deficient for S1P export ( Mfsd2b...
Purpose: Although a moderate proportion of cardiac arrest (CA) patients achieve return spontaneous circulation (ROSC), few survive to discharge, mostly with poor neurological development. As serum phosphate levels were described as elevated after cardiopulmonary resuscitation (CPR), we asked whether these elevations would predict higher risk mortality and impaired outcome in CA following ROSC. Methods: Initial levels, survival, neurologic status at discharge 488 non-traumatic treated single...
Abstract Background and Purpose Remote ischaemic preconditioning (rIPC) for cardioprotection is severely impaired in diabetes, therapeutic options to restore it are lacking. The vascular endothelium plays a key role rIPC. Given that the activity of endothelial nitric oxide synthase (eNOS) inhibited by proline‐rich tyrosine kinase 2 (Pyk2), we hypothesized pharmacological Pyk2 inhibition could eNOS thus remote diabetes. Experimental Approach New Zealand obese (NZO) mice demonstrated features...
Altered plasma sphingosine-1-phosphate (S1P) concentrations are associated with clinical manifestations of atherosclerosis. However, whether long-term elevation endogenous S1P is pro- or anti-atherogenic remains unclear. Here, we addressed the impact permanently high levels on atherosclerosis in cholesterol-fed apolipoprotein E-deficient (ApoE-/-) mice over 12 weeks. This was achieved by pharmacological inhibition S1P-degrading enzyme lyase 4-deoxypyridoxine (DOP). DOP treatment dramatically...
Background: The search for the best therapeutic approach in cardiopulmonary resuscitations (CPR) remains open to question. In this study, we evaluated if Amiodarone administration during CPR was associated with short-term mortality or neurological development. Methods: A total of 232 patients sudden cardiac arrest (CA) shockable rhythms were included our analysis. Propensity score matching based on age, gender, type CA, and duration used stratify between without CPR. Primary endpoints...
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that transport by involved cardiac function. Hypertension-induced remodeling was induced 4-weeks Angiotensin II (AngII) administration and assessed echocardiography. Ca
Identifying patients who may benefit from mechanical circulatory support (MCS) after out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC) remains challenging; thus, a search for helpful biomarkers is warranted. We aimed to evaluate phosphate lactate levels on admission regarding their associations with survival without MCS.In 224 OHCA achieved ROSC, the initial were investigated discriminate in-hospital mortality by receiver operating characteristic (ROC)...
Anemia is common in the old and often observed critically ill patients. Increased age associated with higher mortality following a COVID-19 infection, making patients prone to poor outcomes. We investigated whether anemia at admission ICU or need for blood transfusion was 90-day older, patients.In this prospective multicenter study, of patients≥70 years treated 138 intensive care units (ICU) analyzed. Associations between (WHO definition) discharge from use red cell (RBC) transfusions were...
Aim: The goal of this retrospective analysis was to study the prevalence and treatment most common sexually transmitted infections (STI) in men followed by urologists Germany. Methods: This included a total 347,090 71 urology practices Germany between 2013 2015. first outcome individuals diagnosed with STI following eight types were analysis: chlamydial infection, gonococcal anogenital warts, herpes trichomoniasis, ulcus molle, phthiriasis, syphilis. second who received an appropriate...
Abstract Background Enlargement of the left atrium (LA) predicts future cardiovascular events. Current guidelines recommend cocoa flavanol (CF) intake as it provides and metabolic benefits, although underlying mechanisms are not fully revealed. In this study, we hypothesized that CF reverses LA enlargement a surrogate marker for diastolic dysfunction in elderly individuals without diseases. Methods Results randomized, double-blinded trial, investigated effects on systolic heart function...
Mechanical injury during transradial coronary angiography (TCA) results in the induction of vascular injury. The intake cocoa flavanols seven days prior to and after elective TCA mitigated long-term functional decline hyperplasia.
Abstract Background Loss of functional capacity is one the hallmarks in cardiovascular aging. Cocoa flavanols (CF) exert favorable effects on endothelial function, blood pressure, and inflammation. These health markers worsen with increasing age limit exercise capacity. Aim To investigate effect CF cardiorespiratory-fitness healthy elderly. Methods In a randomized, double-masked, placebo-controlled, parallel-group dietary intervention trial, 68 elderly (55-79 years, 28 female) received...
Abstract Background Endothelial function and cardioprotection through remote ischemic preconditioning (rIPC) are severely impaired in type 2 diabetes mellitus (T2DM). Proline-rich tyrosine kinase (Pyk2), a downstream target of the insulin receptor, reduces endothelial nitric oxide synthase (eNOS) activity. Therapeutic options to rescue T2DM improve outcomes after acute myocardial infarction (AMI) lacking. We hypothesized that vascular endothelium contributes rIPC, inhibition Pyk2 restores...
Cocoa flavanols improve peakVO 2 and exercise capacity in healthy elderly people.