A5084146851- Spaceflight effects on biology
- Cardiac Valve Diseases and Treatments
- High Altitude and Hypoxia
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiovascular and Diving-Related Complications
- Climate Change and Health Impacts
- Thermal Regulation in Medicine
- Exercise and Physiological Responses
- Infective Endocarditis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Fuel Cells and Related Materials
- Geriatric Care and Nursing Homes
- Thermoregulation and physiological responses
- Nutrition and Health in Aging
- Renal function and acid-base balance
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Healthcare Systems and Challenges
- Sex and Gender in Healthcare
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- COVID-19 Impact on Reproduction
- Medical and Biological Ozone Research
Heinrich Heine University Düsseldorf
2020-2025
Düsseldorf University Hospital
2020-2025
Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of Activities Daily Living (ADL) with outcome in this vulnerable patient group. The COVIP study is a prospective international observational that recruited ICU ≥ 70 years admitted COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 no disability), Clinical Frailty Scale...
Abstract Background and Aims Valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) has proven to be an effective treatment option for high-risk patients with degenerated surgical bioprosthetic valves. Multislice computed tomography (MSCT) analysis, the current gold standard procedural planning, certain limitations. Virtual reality (VR) could optimize preprocedural planning by delivering three-dimensional patient-specific information. This study aimed investigate feasibility of...
Purpose: Early lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a >0% might differ from patients inferior terms of intensive care management outcomes. This study analyzes large collective regards to baseline risk distribution Methods: In total, 3299 were included this analysis, consisting 1528 (46%) ≤0% 1771 (54%) patients. The primary endpoint was unit (ICU) mortality. Multilevel logistic regression analyses used compare...
Abstract Gravitational changes between micro- and hypergravity cause several adaptations alterations in the human body. Besides muscular atrophy immune system impairment, effects on circulatory have been described, which can be associated with a wide range of blood biomarker changes. This study examined nine individuals (seven males, two females) during parabolic flight campaign (PFC). Thirty-one parabolas were performed one day, resulting ~22 s microgravity each parabola. Each participant...
Profound knowledge about cardiovascular physiology in the setting of microgravity can help course preparations for human space missions. So far, influences on system have been demonstrated, particularly pertaining to venous fluid shifts. Yet, little is known mechanisms these adaptations continuous macrocirculatory level and regarding microcirculation.Twelve healthy volunteers were subjected alternating hypergravity parabolic flight maneuvers. Under conditions, as well normal gravity,...
Older critically ill patients with COVID-19 have been the most vulnerable during ongoing pandemic, men being more prone to hospitalization and severe disease than women. We aimed explore sex-specific differences in treatment outcome after intensive care unit (ICU) admission this cohort. performed a analysis ≥ 70 yr of age who were included international prospective multicenter COVIP study. All analyzed for ICU characteristics. multilevel adjusted regression elucidate associations sex 30-day...
Diagnostic and risk stratification are limited in emergencies. The measurement of microcirculation might identify patients with poor perfusion but compensated macrocirculation such as beginning shock. This proof-of-concept study examines whether sublingual prehospital sidestream dark-field microscopy is feasible.This prospective observational included receiving medical aid by an emergency ambulance who had a spontaneous circulation offered access to the mucosa. Sublingual was performed using...
PURPOSECritically ill elderly patients who suffer from Sars-CoV-2 disease are at high risk for organ failure. The modified MELD-XI score has not been evaluated outcome prediction in these most vulnerable patients.METHODSThe Corona Virus (COVID19) Very Elderly Intensive Care Patients study (COVIP, NCT04321265) prospectively recruited on intensive care units (ICU), were = 70 years. Data collected March 2020 to February 2021. was calculated using the highest serum bilirubin and creatinine ICU...
"Spaceflight associated neuro-ocular syndrome" (SANS) represents a challenging health condition in modern space medicine. Forty-eight percent of astronauts are diagnosed with SANS after long-term missions. The pathophysiological mechanism seems to be multifactorial, and yet remains unknown. In this proof-of-concept study we plan investigate retinal microcirculatory changes weightlessness aim identify their role the development SANS.Healthy individuals will take part parabolic flight...
Dehydration occurs frequently in older patients and constitutes a significant clinical problem.This proof-of-concept study examines whether 1) sublingual measurement dehydrated old is feasible, 2) frailty incompliance old, awake affects video-quality, 3) dehydration impacts microcirculationMETHODS:This prospective observational included clinically aged ≥65 years immediately after admission. was assessed clinically. A sidestream dark field camera (SDF) used for measurement. Video-quality...
Abstract Background Aortic valve stenosis treated by transcatheter aortic implantation (TAVI) is a fast-growing section in interventional cardiology. Optimal depth (ID) of self-expanding TAVI devices an important condition for hemodynamic and clinical outcomes. The cusp overlap technique (COT) offers optimized fluoroscopic projections with due to improved anatomic discrimination elongation the left ventricular outflow tract isolation non-coronary (NCC) better assessment ID. Purpose This...
COVID-19 is associated with cytokine release in critical disease states. Thus, absorption has been proposed as a therapeutic option. This study investigated the influence of on mortality old patients and renal failure admitted to intensive care units (ICU).This retrospective analysis prospective international observation (the COVIP study) analysed ICU patients≥70 years COVID-19. Data Sequential Organ Failure Assessment (SOFA) score, clinical frailty scale (CFS), therapy details including...
Abstract Background/Introduction Optimizing valve implantation depth (ID) plays a crucial role in minimizing conduction disturbances and achieving optimal functional integrity. Until now, the impact of intraprocedural fast (FP) or rapid ventricular pacing (RP) on has not been investigated. Purpose Therefore, we aimed to 1) evaluate different maneuvers ID, 2) identify independent predictors deep ID. Methods 562 TAVR patients with newer-generation self-expandable devices were retrospectively...