Marcus Franz
A5027307162- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Antimicrobial Resistance in Staphylococcus
- Protease and Inhibitor Mechanisms
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic Disease and Treatment Approaches
- Frailty in Older Adults
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Peptidase Inhibition and Analysis
- Cardiac Health and Mental Health
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
Jena University Hospital
2015-2024
Friedrich Schiller University Jena
2015-2024
Agaplesion Diakonieklinikum Rotenburg
2024
Erasmus MC
2023
University Hospital of Larissa
2021
Augsburg University
2019
Khanty-Mansiysk State Medical Academy
2018
Charité - Universitätsmedizin Berlin
2018
Deutsches Herzzentrum der Charité
2018
Albertinen Diakoniewerk
2018
Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE may lead to a sudden release of inflammatory mediators, which is associated postoperative organ dysfunction. We investigated effect hemoadsorption during on Methods: This multicenter, randomized, nonblinded, controlled trial assigned undergoing cardiac for (integration CytoSorb cardiopulmonary bypass) or control. The primary outcome (change sequential failure...
Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state cardiac remodeling. The deacetylase sirtuin 3 (SIRT3) plays a pivotal role in maintenance function through regulating acetylome. It is interesting note that unique systemic microRNAs have been shown play important remodeling by modulating key signaling elements myocardium.Cellular was analyzed human cardiomyocyte-like AC16 cells, acetylation levels...
Background— Transcatheter caval valve implantation is under evaluation as a treatment option for inoperable patients with severe tricuspid regurgitation (TR). The procedure involves the catheter-based of bioprosthetic valves in inferior vena cava and superior to treat symptoms associated TR. This study first evaluate feasibility, safety, efficacy this interventional concept. Methods Results— Twenty-five (mean age, 73.9±7.6 years; women, 52.0%) symptomatic TR despite optimal medical deemed...
Purpose Blood urea nitrogen (BUN) was reported to be associated with mortality in heart failure patients. We aimed evaluate admission BUN concentration a heterogeneous critically ill patient collective admitted an intensive care unit (ICU) for prognostic relevance. Methods A total of 4176 medical patients (67±13 years) German ICU between 2004 and 2009 were included. Follow-up performed retrospectively May 2013 November 2013. Association both intra-hospital long-term investigated by Cox...
Abstract Background This large-scale analysis pools individual data about the Clinical Frailty Scale (CFS) to predict outcome in intensive care unit (ICU). Methods A systematic search identified all clinical trials that used CFS ICU (PubMed searched until 24th June 2020). All patients who were electively admitted excluded. The primary was mortality. Regression models estimated on complete set, and for missing data, multiple imputations utilised. Cox adjusted age, sex, illness acuity score...
Shock is a life-threatening condition characterized by substantial alterations in the microcirculation. This study tests hypothesis that considering sublingual microcirculatory perfusion variables therapeutic management reduces 30-day mortality patients admitted to intensive care unit (ICU) with shock. randomized, prospective clinical multicenter trial-recruited an arterial lactate value above two mmol/L, requiring vasopressors despite adequate fluid resuscitation, regardless of cause All...
The lactate/albumin ratio has been reported to be associated with mortality in pediatric patients sepsis. We aimed evaluate the for its prognostic relevance a larger collective of critically ill (adult) admitted an intensive care unit (ICU). A total 348 medical German ICU sepsis between 2004 and 2009 were included. Follow-up was performed retrospectively May 2013 November 2013. association (cut-off 0.15) both in-hospital post-discharge investigated. An optimal cut-off calculated by means...
In intensive care units (ICU) octogenarians become a routine patients group with aggravated therapeutic and diagnostic decision-making. Due to increased mortality reduced quality of life in this high-risk population, medical decision-making fortiori requires an optimum risk stratification. Recently, the VIP-1 trial prospectively observed that clinical frailty scale (CFS) performed well ICU overall-survival short-term outcome prediction. However, it is known healthcare systems differ 21...
Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There wide variation the approach analysing relationship between CFS score and mortality after admission ICU. This study aimed evaluate influence of modelling on association short-term quantify prognostic value this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old 26 countries. primary...
Previous studies on hypothyroid subjects have indicated serious psychiatric symptoms affecting the patients' quality of life. The present prospective cross-sectional study's aim was to examine these in thyroid patients with different functional states. A total 254 (age: 56 +/- 14 years [mean standard deviation], 181 female, 73 male) referred a hospital for radioiodine treatment hyperthyroidism or follow-up differentiated cancer, respectively, were included. All underwent twelve-item general...
In 45 consecutive patients mitral valve replacement was performed leaving the posterior leaflet and its chordal attachment to both papillary muscles intact (Lillehei's technique). Most showed moderate severe pulmonary hypertension before surgery, 15 of had double operations 4 a triple procedure. All survived were discharged, postoperative courses being remarkably uneventful with only very limited need inotropic support in 3 resumption spontaneous respiration within first 20 hours after...
J Oral Pathol Med (2011) 40: 46–54 Epithelial–mesenchymal transition (EMT) is suggested to be crucial for the development of an invasive and metastatic carcinoma cell phenotype. Therefore, definition this phenotype great clinical interest. We recently evidenced vimentin positive cells in oral squamous (OSCC) front expressing laminin γ2 chain mRNA implicating EMT origin these cells. To further elucidate nature cells, we have investigated relation between criteria laminin-332 expression a...
Purpose MELD-XI, an adapted version of Model for End-stage Liver Disease (MELD) score excluding INR, was reported to predict outcomes e.g. in patients with acute heart failure. We aimed evaluate MELD-XI critically ill admitted intensive care unit (ICU) prognostic relevance. Methods A total 4381 medical (66±14 years, 2862 male) a German ICU between 2004 and 2009 were included retrospectively investigated. Admission diagnoses myocardial infarction (n = 2034), sepsis 694) failure 688). divided...
Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity mortality. That why ILD screening at very early stage, the onset of IRD, essential. The objective present study was to evaluate diagnostic value utility stepwise approach as potential tool patients newly diagnosed IRD.