A5077575390- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Fuel Cells and Related Materials
- Atrial Fibrillation Management and Outcomes
- Dialysis and Renal Disease Management
- Cardiac Ischemia and Reperfusion
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Aortic Disease and Treatment Approaches
- Oral microbiology and periodontitis research
- Pneumocystis jirovecii pneumonia detection and treatment
- Gut microbiota and health
- Nutrition and Health in Aging
- Nitric Oxide and Endothelin Effects
- Hemodynamic Monitoring and Therapy
Columbia University Irving Medical Center
2016-2025
Columbia University
2016-2025
New York Hospital Queens
2014-2025
NewYork–Presbyterian Hospital
2016-2025
Presbyterian Hospital
2007-2025
Texas Health Dallas
2003-2024
Albert Einstein College of Medicine
2001-2022
Montefiore Medical Center
2016-2022
Cardiovascular Research Foundation
2020
University of Chicago
2015-2017
Continuous-flow left ventricular assist systems increase the rate of survival among patients with advanced heart failure but are associated development pump thrombosis. We investigated effects a new magnetically levitated centrifugal continuous-flow that was engineered to avert
Background— Indirect evidence implicates endothelial dysfunction in the pathogenesis of vascular diseases associated with obstructive sleep apnea (OSA). We investigated directly whether and inflammation occur vivo endothelium patients OSA. The effects continuous positive airway pressure (CPAP) therapy on function repair capacity were assessed. Methods Results— Thirty-two newly diagnosed OSA 15 control subjects studied. Proteins that regulate basal nitric oxide (NO) production (endothelial NO...
The HeartMate 3 (HM3) Left Ventricular Assist System (LVAS) (Abbott) is a centrifugal, fully magnetically levitated, continuous-flow blood pump engineered to enhance hemocompatibility and reduce shear stress on components. MOMENTUM trial (Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With 3) compares the HM3 LVAS with II (HMII) advanced heart failure refractory medical management, irrespective therapeutic intention (bridge transplant...
Aortic insufficiency (AI) is increasingly recognized as a complication of continuous flow left ventricular assist device support; however, its long-term prevalence, clinical significance, and efficacy potential interventions are not well known.We studied the prevalence management AI in 232 patients with at our institution. Patients aortic valve (AV) surgery before implantation were excluded from analysis. To examine de novo AI, without preoperative divided into retrospective prospective...
Left ventricular distention (LVD) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is increasingly recognized but seldom reported in the literature. The current study defined LVD as not present (LVD−); subclinical (LVD+, evidence of pulmonary edema on chest radiograph AND artery diastolic blood pressure greater than 25 mm Hg within first 2 hours intensive care unit admission); or clinical (LVD++, need for decompression left ventricle immediately following VA-ECMO...
Endothelial cells have been shown to activate T cell responses alloantigens, triggering transplant rejection. However, they may also play a role in tolerance induction. Using RT–PCR we show here that alloantigen specific CD8+CD28− suppressor generated vitro are FOXP3 positive and interact with human endothelial cells. This interaction results the induction of inhibitory receptors down-regulation costimulatory adhesion molecules, thus rendering tolerogenic. In turn, tolerized elicit...
Background— Unrecognized obstructive sleep apnea (OSA) is highly prevalent in obesity. Both obesity and OSA are associated with vascular endothelial inflammation increased risk for cardiovascular diseases. We investigated directly whether the alterations that attributed commonly to fact related OSA. Methods Results— Seventy-one subjects a body mass index ranging from normal obese underwent attended polysomnography. To assess oxidative stress directly, we quantified expression of nuclear...
Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state cardiac remodeling. The deacetylase sirtuin 3 (SIRT3) plays a pivotal role in maintenance function through regulating acetylome. It is interesting note that unique systemic microRNAs have been shown play important remodeling by modulating key signaling elements myocardium.Cellular was analyzed human cardiomyocyte-like AC16 cells, acetylation levels...
AimsVolume overload and venous congestion are typically viewed as a consequence of advanced acute heart failure (HF) renal (RF) although it is possible that hypervolaemia itself might be critical intermediate in the pathophysiology these diseases. This study aimed at elucidating whether peripheral sufficient to promote changes inflammatory, neurohormonal, endothelial phenotype similar those observed HF RF.
Background: The MOMENTUM 3 study (Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3) has demonstrated that the (HM3) pump is associated with reduced strokes compared II (HMII) device. We now perform a comprehensive analysis stroke events to evaluate their longitudinal occurrence, clinical correlates, patterns, and impact on outcome across 2-year duration support. Methods: randomized controlled trial HM3 centrifugal-flow...
Background— Time course and predictors of myocardial recovery on contemporary left ventricular assist device support are poorly defined because limited number patients at any implanting center. This study sought to investigate using multicenter data from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Methods Results— Thirteen thousand four hundred fifty-four adult were studied. Device explant rates 0.9% 1-year, 1.9% 2-year, 3.1% 3-year follow-up....
Doppler ultrasound is the clinical gold standard for noninvasive blood pressure (BP) measurement among continuous-flow left ventricular assist device patients. The relationship of BP to systolic (SBP) and mean arterial (MAP) uncertain measurements require a clinic visit. We studied between both arterial-line (A-line) SBP MAP. Validity reliability Terumo Elemano Monitor, novel slow cuff-deflation that could potentially be used by patients at home, were assessed.Doppler made in triplicate 60...
Mortality for refractory cardiogenic shock remains high. In this patient cohort, there have been mixed results in mechanical circulatory support device use as a bridge-to-decision therapy. We evaluated continuous-flow external ventricular assist (VAD), CentriMag VAD (Thoratec Corp., Pleasanton, CA), patients with various causes of shock.This is retrospective review adult who underwent surgical insertion From January 2007 through June 2012, 143 received VAD. The cause was failure medical...