A5028514265- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Organ and Tissue Transplantation Research
- Healthcare Policy and Management
- Organ Donation and Transplantation
- Pharmacogenetics and Drug Metabolism
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Cardiac pacing and defibrillation studies
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Drug Transport and Resistance Mechanisms
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Fuel Cells and Related Materials
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
Emory University
2016-2024
Columbia University Irving Medical Center
2013-2022
University Medical Center
2022
Columbia University
2013-2021
New York Hospital Queens
2020-2021
NewYork–Presbyterian Hospital
2020-2021
Presbyterian Hospital
2020
Icahn School of Medicine at Mount Sinai
2016
University of Washington
2016
University of North Carolina at Chapel Hill
2003-2007
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known have anti-inflammatory antithrombotic properties, been studied the setting of viral infections, but their benefit has not assessed COVID-19. This is retrospective analysis patients admitted with COVID-19 from February 1 st through May 12 th , 2020 study...
A single-nucleotide polymorphism (A6986G) in the cytochrome P-450 3A5 ( CYP3A5) gene distinguishes an expressor *1) and a reduced-expressor *3) allele largely predicts CYP3A5 content liver intestine. is prevailing CYP3A isoform kidney. We report that, among renal microsomes from 21 organ donors, those *1/ *3 individuals had at least eightfold higher mean kidney microsomal 18-fold catalytic activity than did *3/ P = 0.0001 0.0137, respectively). also significant associations between A6986G...
Background: There is mixed evidence of racial and socioeconomic disparities in heart transplant outcomes. Their underlying cause—and whether individual- or community-level traits are most influential—remains unclear. The current study aimed to characterize outcomes identify time trends mediators these disparities. Methods Results: We used United Network for Organ Sharing registry data included 33 893 adult recipients between 1994 2014. Socioeconomic status (SES) indicators insurance,...
Background: Bridge to transplantation (BTT) with left ventricular assist devices (LVADs) is a mainstay of therapy for heart failure in patients awaiting (HT). Criteria HT listing do not differ between medically managed and those mechanically bridged HT. The objectives the present study were evaluate impact BTT LVAD on posttransplantation survival, describe differences causes 1-year mortality patients, risk factors without at time Methods: Using United Network Organ Sharing database, we...
In the USA, transthyretin cardiac amyloidosis usually results from 'wild-type' (senile [SCA]) or V122I variant.We compared presentations and outcomes among SCA patients referred to Center for Advanced Cardiac Care at Columbia University Medical (NY, USA) between 2001 2012.V122I were younger (mean: 71 years, standard deviation [SD]: 7) than 77, SD: 6; p = 0.0002) 96% black with 3% of (p < 0.0001). Average ejection fraction was lower 25% [SD: 12] vs mean: 47% 15]; 0.0001), as mean index....
Background: Continuous-flow left ventricular assist devices (CF-LVADs) have become a standard treatment choice in advanced heart failure patients. We hypothesized that practice patterns with regards to CF-LVAD utilization vary significantly among transplant centers and impact waitlist outcomes. Methods Results: The United Network for Organ Sharing registry was queried identify adult patients who were waitlisted transplantation (HT) between 2008 2015. Each patient assigned propensity score...
Low socioeconomic status (SES) is a known risk factor for heart failure, mortality among those with and poor post transplant (HT) outcomes. This study sought to determine whether SES associated decreased waitlist survival while on left ventricular assist device (LVADs) support after HT.A total of 3361 adult patients bridged primary HT an LVAD between May 2004 April 2014 were identified in the UNOS database (United Network Organ Sharing). was measured using Agency Healthcare Research Quality...
Galectin-3 is a marker of myocardial inflammation and fibrosis shown to correlate with morbidity mortality in heart failure (HF). We examined the utility galectin-3 as severity HF, response levels ventricular assist device (LVAD) implantation or transplantation (HTx), its use prognostic indicator. Plasma was measured using commercially available ELISA assay patients stable HF (n = 55), severe 63), at 3 17) 6 14) months post-LVAD LVAD explantation 23), following HTx 85) healthy controls 30)....
Despite several studies suggesting that CYP3A5 expression can influence the extent of hepatic CYP3A-mediated inhibition, a systematic in vitro-in vivo evaluation this potential clinically important issue has not been reported. Using representative probes from two distinct CYP3A substrate subgroups (midazolam, erythromycin), inhibitory potency fluconazole was evaluated pooled human liver microsomes (HLM) with low or high specific content, recombinant enzymes (rCYP3A), and healthy volunteers...
Abstract The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), can result in a hyperinflammatory state, leading to distress (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known have anti-inflammatory antithrombotic properties, been studied setting of viral infections ARDS, but their benefit has not assessed COVID-19. Thus, we sought determine whether antecedent statin use is associated with...
Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used in advanced heart failure patients. Recent studies suggest that low socioeconomic status (SES) predicts worst survival after transplantation. Both individual-level and neighborhood-level SES (nSES) have been linked to cardiovascular health; however, the impact of CF-LVAD patients remains unknown. We hypothesized is a major determinant candidacy postimplantation outcomes. A retrospective chart review was...