A5067777754- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Salivary Gland Disorders and Functions
- Circular RNAs in diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Systemic Sclerosis and Related Diseases
- Cardiac Structural Anomalies and Repair
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Cardiac Health and Mental Health
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Concrete Corrosion and Durability
- Magnetic Properties and Applications
- Parathyroid Disorders and Treatments
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Wnt/β-catenin signaling in development and cancer
- Long-Term Effects of COVID-19
Medizinische Hochschule Hannover
2015-2024
Imperial College London
2021
Abstract Aims Coronavirus disease 2019 (COVID‐19) is a still growing pandemic, causing many deaths and socio‐economic damage. Elevated expression of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry receptor angiotensin‐converting enzyme on cardiac cells patients with heart diseases may be related to cardiovascular burden. We have thus analysed inflammatory microRNAs (miRs), sensitive markers damage, in critically ill, ventilated COVID‐19 or influenza‐associated distress...
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and associated with a high risk sudden cardiac death. HCM characterized by pronounced hypertrophy cardiomyocytes, fiber disarray development fibrosis can be divided into non-obstructive (HNCM) obstructive form (HOCM) therefore requiring personalized therapeutic therapies. In present study, we investigated expression patterns several circulating circular RNAs (circRNAs) as potential biomarkers in...
Abstract Aims Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It distinguished from myocardial infarction (MI) a characteristic pattern of ventricular basal hypercontractility with hypokinesis apical segments, and in the absence culprit coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 miR-26a, which differentiate TTS MI at presentation, were mechanistically...
MicroRNAs (miRNAs) can regulate gene expression, controlling numerous cellular processes. Dysregulation of miRNA function is linked to various diseases, making them attractive diagnostic and therapeutic targets. Examples include hsa-miR-92a-3p, hsa-miR-126-3p, hsa-miR-143-3p, hsa-miR-145-5p hsa-miR-204-5p, which are associated with endothelial function. Their prevalence in Sjögren's disease (SjD) unknown. We assessed the these miRNAs serum patients SjD, correlating levels cardiovascular risk...
This study aimed to investigate the association of circulating biomarkers with echocardiographic parameters atrial remodelling and their potential for predicting fibrillation (AF). In patients without AF (n = 21 n 60) following serum were determined: soluble ST2 (sST2), Galectin-3 (Gal-3), N-terminal pro-brain natriuretic peptide (NT-proBNP), microRNA (miR)-21, -29a, -133a, -146b -328. Comprehensive transthoracic echocardiography was performed in all participants. Biomarkers significantly...
Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease with high risk for sudden cardiac death in young people. As subtype, hypertrophic obstructive (HOCM) additionally has left ventricular outflow gradient, showing stronger symptoms and requires different treatment compared nonobstructive (HNCM). In this study our aim was to investigate the regulation of mitochondrial remodeling associated long noncoding RNAs (lncRNAs) blood patients affected HOCM HNCM. We included 28 HNCM, 57...
Amyloidosis is caused by dysregulation of protein folding resulting in systemic or organ specific amyloid aggregation. When affecting the heart, amyloidosis can cause severe heart failure, which associated with a high morbidity and mortality. Different subtypes cardiac exist e.g. transthyretin senile amyloidosis. Today, diagnostics primarily based on biopsies no clinically used circulating blood-based biomarkers existing. Therefore, our aim was to identify microRNAs patients different forms...
Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in plaques may promote Cadherins (CDHs) form adherens junctions and are known stabilizers plaques. To date, the expression patterns cadherin have not been well investigated MI aortic VSMCs. We aimed investigate genes wall patients with without MI. Laser capture microdissected VSMCs were obtained from...
Objectives Cardiovascular comorbidities are common in patients with autoimmune diseases. This study investigates the extent of subclinical atherosclerosis primary Sjögren’s syndrome (pSS). Correlations clinical factors such as organ involvement (OI) or disease activity were analysed and oxLDL antibodies (oxLDL ab) measured potential biomarkers vascular damage. Methods Patients pSS consecutively included from rheumatology outpatient clinic. Age- sex-matched controls recruited (2:1 ratio)....
Telomere length is a marker of biological aging. Short leukocyte telomere has been associated with various conditions including cardiovascular disorders. Here, we evaluated if patients hypertrophic cardiomyopathy have altered and whether this disease severity. A quantitative polymerase chain reaction-based method was used to measure peripheral blood in 59 healthy control subjects well-characterized cohort 88 diagnosed cardiomyopathy: 32 non-obstructive (HNCM) 56 obstructive (HOCM). We...
Echocardiographic parameters representing impaired left atrial (LA) function and remodeling are of high value to predict fibrillation (AF). This study aimed develop a prediction model for AF easily apply in clinical routine containing echocardiographic associated with LA and-function. monocentric, semi-blinded, controlled analysis included 235 patients derive model. was tested validation cohort encompassing 290 cardiovascular inpatients. The derivation 54 (23%) 66 AF, respectively....
Abstract Ventricular tachyarrhythmia (VTA) are frequent arrhythmias in patients with hypertrophic cardiomyopathy (HCM). Representing a major risk factor for sudden cardiac death, Holter ECG at first clinical presentation appears insufficient. This study aims to investigate the ability of routinely obtained parameters associated myocardial remodeling stratifying VTA HCM. In this monocentric analysis, HCM underwent 12-channel electrocardiography and echocardiography, including tissue doppler...
Background Hypertrophic cardiomyopathy (HCM), the most common genetic heart disease, is classified into hypertrophic non-obstructive and obstructive (HOCM). Patients with HOCM coexisting failure or arterial hypertension are often prescribed afterload-reducing drugs. Although recommended in current guidelines, data on direct effect of discontinuing medication scarce. This study aims to demonstrate benefit patients. Methods monocentric retrospective analysis included 24 patients medication,...
Driveline (DL) damages are a common difficulty among ventricular assist devices (VAD). Repairing the electrical fibers inside DL on running pump is hazardous and requires technical expertise, which not easily available site. A new feature of HeartMate3 (Abbott, U.S.A.) LVAD modular driveline that allows an easy exchange cord. In this report we analyze our experiences with feature.We performed retrospective analysis 302 patients who underwent either HeartMate II or 3 implantation between...
Background Fibroblast activation protein α (FAP), a membrane glycoprotein with dipeptidyl-peptidase and collagenase properties, is expressed in atherosclerotic plaques remodeling of the extracellular matrix based on fibrosis. Fibrosis main contributor atrial cardiomyopathies. In acute MI, circulating FAP associated outcome. Here, we investigated correlation to echocardiographic parameters neurological impairment ischemic stroke. Methods Circulating plasma concentrations were determined by...
<h3>Background</h3> It is well established that patients with inflammatory rheumatic diseases have an increased cardiovascular risk [1]. Most data exists for rheumatoid arthritis, but there are also a few studies primary Sjoegren's syndrome (pSS)[2]. <h3>Objectives</h3> Aim of our study was to investigate the extent subclinical atherosclerosis in large group pSS compared control subjects without pSS. Secondary, correlations clinical factors, such as organ involvement or antibody positivity,...
Background: Specific microRNAs (miRs) have been implicated in the pathophysiology of atherosclerosis and may represent interesting diagnostic therapeutic targets carotid stenosis. We hypothesized that levels specific circulating miRs are altered patients with symptomatic stenosis (sCS) comparison to those asymptomatic (aCS) planned undergo endarterectomy (CEA). also studied whether miR associated plaque vulnerability stability over time after CEA. Methods: Circulating vascular-enriched...
<h3>Background:</h3> Micro Ribonucleic acids, also known as microRNAs or miRs are critical regulators of gene expression that control various cell processes and disease progression. Their dysregulation is associated with diseases, making them promising diagnostic therapeutic targets. Among them, hsa-miR-92a-3p, hsa-miR-126-3p, hsa-miR-143-3p, hsa-miR-145-5p hsa-miR-204-5p have been endothelial function. However, their role in primary Sjögren's syndrome (pSS) remains unexplored....
Here, we report on a patient with deep vein thrombosis of the right leg, in whom diagnostic work-up revealed previously unknown chondrosarcoma tibia. Physical examination firm, nondisplaceable mass dorsal side knee that appeared as cystic formation ultrasound. X‑ray, computed tomography, and magnetic resonance imaging were consistent chondrosarcoma, which had likely provoked by local compression or paraneoplastic mechanisms. After resection tumor, anticoagulation was continued. In review all...
Mechanical heart valves (MHVs) are preferred prosthesis types in many, especially younger patients who need surgical valve replacement. Although echocardiography is most frequently performed for assessment during follow-up, ultrasound artifacts usually preclude a precise investigation of function. Cinefluoroscopy (CF) simple and effective method to analyze quantify opening closing leaflets but requires careful visualization the using optimal viewing angles. Here, we investigated quality CF...