A5103200623- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Medical and Biological Ozone Research
- COVID-19 Clinical Research Studies
- Bone Tumor Diagnosis and Treatments
- Social Robot Interaction and HRI
- Laser Applications in Dentistry and Medicine
- AI in Service Interactions
- Oral and Maxillofacial Pathology
- Head and Neck Anomalies
- Silicone and Siloxane Chemistry
- Embedded Systems and FPGA Design
- Polymer Nanocomposite Synthesis and Irradiation
- Electron and X-Ray Spectroscopy Techniques
- Dermatological and COVID-19 studies
- Medicinal Plants and Neuroprotection
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ultrasound in Clinical Applications
- Musculoskeletal synovial abnormalities and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Methemoglobinemia and Tumor Lysis Syndrome
- Embedded Systems Design Techniques
- Hormonal Regulation and Hypertension
- Immune Response and Inflammation
Medizinische Hochschule Hannover
2017-2024
Medanta The Medicity
2024
Govt. Dental College & Hospital
2023-2024
National Institute of Mental Health and Neurosciences
2024
Mata Chanan Devi Hospital
2021-2023
University of Georgia
2022
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2022
Post Graduate Institute of Medical Education and Research
2022
Punjabi University
2021
Kirloskar Hospital
2021
Cardiac fibroblasts (CFs) drive extracellular matrix remodeling after pressure overload, leading to fibrosis and diastolic dysfunction. Recent studies described the role of long noncoding RNAs (lncRNAs) in cardiac pathologies. Nevertheless, detailed reports on lncRNAs regulating CF biology describing their implication are still missing.Here, we aimed at characterizing lncRNA expression murine CFs chronic overload identify CF-enriched investigate function contribution dysfunction.Global...
RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about role of heart failure induced by chemotherapy drug doxorubicin their interaction with circular RNAs.We aimed identify key involved doxorubicin-mediated elucidate function.Global transcriptome profiling from murine myocardium exposed identified 5 differentially RBPs. Expression RBP QKI (Quaking) response was strongly downregulated rodent cardiomyocytes...
Abstract Aims Coronavirus disease 2019 (COVID‐19) is a still growing pandemic, causing many deaths and socio‐economic damage. Elevated expression of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry receptor angiotensin‐converting enzyme on cardiac cells patients with heart diseases may be related to cardiovascular burden. We have thus analysed inflammatory microRNAs (miRs), sensitive markers damage, in critically ill, ventilated COVID‐19 or influenza‐associated distress...
Improved therapy of cancer has significantly increased the lifespan patients. However, survivors face an risk cardiovascular complications due to adverse effects therapies. The chemotherapy drug doxorubicin is well known induce myofibril damage and cardiac atrophy. Our aim was test potential counteracting pro-hypertrophic miR-212/132 family in doxorubicin-induced cardiotoxicity. In vitro, overexpression cluster primary rodent human iPSC-derived cardiomyocytes inhibited toxicity. Next, a...
The factors involved in cell differentiation have recently garnered interest for their role inhibition of pathogenesis various tumors. However, glioblastoma (GBM) remains poorly understood. We analyzed Cancer Genome Atlas (TCGA) GBM data and found significant downregulation neurogenic factor NeuroD2 patients. Low levels were to be correlated with poor overall survival patients TCGA dataset as well our cohort. Interestingly, was shown transcriptionally induced by p53 post‐transcriptionally...
Abstract Background Capillary leakage is a key contributor to the pathological host response infections. The underlying mechanisms remain incompletely understood, and role of microRNAs (MIR) has not been investigated in detail. We hypothesized that specific MIRs might be regulated directly endothelium thereby contributing vascular leakage. Methods SmallRNA sequencing endotoxemic murine pulmonary endothelial cells (ECs) was done detect MIRs. In vivo models: transgenic zebrafish...
This paper illustrates the implementation of our proposed voice assistant that provides assistance to disabled personalities over website. ARA-the is a software agent can interpret human speech and respond via synthesized voices. The most popular assistants are Siri, Alexa, Cortana, Google Assistant, which all be found on smart phones dedicated speakers. As become more widely used, but have complex functionality only open when we click mic option, this will start command, easier for people...
Polymer composites in various forms and configuration are being developed an effort to provide lighter weight construction, better optical thermal properties maintain adequate strength stability. To this end thin film polymer (PMMA) nanocomposites synthesized for purpose of influencing luminescence using CdS nanocrystals as filler without incurring losses mechanical properties, were examined determine elastic modulus degree dispersion. Optical absorption spectroscopy has been used finding...
Aim: To evaluate the clinical efficacy of vitamin E and C application on healing after gingival depigmentation procedure. Materials Methods: A Split mouth study was planned for subjects with melanin hyperpigmentation in maxillary and/or mandibular arches. Each site randomly divided into two groups. Scalpel Surgical Technique performed under local anesthesia. After procedure applied group 1 2. The Healing Index Visual Analog Scale pain were recorded 15th day 45th postoperatively. Results:...
Despite extensive research, there is an unmet need for developing disease-modifying therapies Parkinson’s disease (PD). Failure of certain landmark clinical trials has highlighted the a better understanding pathogenesis as well identifying hurdles in drug candidates and designing trials. While adhering to these needs, several promising are currently underway with hope reliable targets. There also conduct research on plant-based natural products use them therapeutic PD. In this context, many...
Cerebral creatine deficiency syndrome-3 is a rare autosomal recessive disorder characterized by disturbance of expressive and cognitive speech, developmental delay, intellectual myopathy. In some cases, it associated with behavioral issues seizures which usually have an early onset. A 44-month-old girl presented complaints speech psychomotor regression, features proximal Contrast-enhanced magnetic resonance imaging brain was essentially normal. Multivoxel spectroscopy (MRS) demonstrated...
Aim: The aim of this study was to evaluate the clinical efficacy Vitamin E and C application on healing after gingival depigmentation (GD) procedure. Materials Methods: A split-mouth planned for subjects with melanin hyperpigmentation in maxillary and/or mandibular arches. Each site randomly divided into two groups. scalpel surgical technique performed under local anesthesia. After procedure, applied Group 1, 2. index Visual Analog Scale scores pain were recorded 15 th day 45...
Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply and myocardial hypoxia lead to tissue damage impairment function. To best our knowledge, primary functional effects in multicellular model living slices (LMSs) have not been investigated so far. In this study, we analyzed force generation, ultrastructure, gene expression, proteome changes rat LMS after 24 h ex vivo culture normal reduced levels (O2). We observed a significant reduction absolute slowdown...
In recent years, multimodal AI has seen an upward trend as researchers are integrating data of different types such text, images, speech into modelling to get the best results. This project leverages and matrix factorization techniques for representation learning, on text image simultaneously, thereby employing widely used Natural Language Processing (NLP) Computer Vision. The learnt representations evaluated using downstream classification regression tasks. methodology adopted can be...
Case: We report a rare case of dysplasia epiphysealis hemimelica in an 11-year-old male child involving the patella. The patient noticed swelling right knee 6 months before presentation. On evaluation, there was mass lesion originating from superior pole patella extending into suprapatellar pouch. opening joint, it found to be mainly cartilaginous nature. Surgical excision carried out. Conclusion: Trevor disease should considered differential diagnosis children. recommended treatment is...
The quandary over Antiviral Therapy for a COVID-19 Patient with Glucose-6-Phosphate Dehydrogenase Deficiency, Hypertension, and Resolved Hepatitis B Infection: A Case Report
Platelet concentrates (PCs) such as platelet-rich plasma and fibrin (PRF) are commonly used in various surgical procedures medical well dental fields, oral maxillofacial surgery, plastic surgery sports medicine. The main motive is to elicit all the components of a blood sample that can be promote healing regeneration. PCs came long way since their existence 1954 from titanium-PRF, advanced-PRF injectable-PRF being introduced newly. These have been successfully applied periodontal...