A5057003434- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Curcumin's Biomedical Applications
- Genetic Neurodegenerative Diseases
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Muscle Physiology and Disorders
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
- Tryptophan and brain disorders
- Genomics and Chromatin Dynamics
- Neurological disorders and treatments
- RNA and protein synthesis mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cannabis and Cannabinoid Research
- DNA and Nucleic Acid Chemistry
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
Chhattisgarh Kamdhenu Vishwavidyalaya
2024
National Institute of Mental Health and Neurosciences
2015-2024
Social Change and Development
2024
University of Agricultural Sciences, Bangalore
2024
Indian Institute of Management Visakhapatnam
2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2024
Ashoka University
2023
Tamil Nadu Veterinary and Animal Sciences University
2022
Vels University
2020
Sri Devaraj Urs Medical College
2017
Selective damage of mitochondrial complex I within the dopaminergic neurons substantia nigra is central event during Parkinson disease. Peroxynitrite one important free radicals probably mediating damage. inhibits brain mainly by 3-nitrotyrosine and nitrosothiol formation, but how these modifications alter structure–function relation unclear. Curcumin pretreatment protects mitochondria against peroxynitrite in vitro direct detoxification prevention formation vivo elevation total cellular...
Abstract Traumatic brain injury ( TBI ) contributes to fatalities and neurological disabilities worldwide. While primary causes immediate damage, secondary events contribute long‐term defects. Contusions (Ct) are injuries correlated with poor clinical prognosis, can expand leading delayed deterioration. Pericontusion PC (penumbra), the region surrounding Ct, also edema, increased intracranial pressure, ischemia, outcome. Analysis of Ct therefore assist in understanding pathobiology its...
Muscular dystrophies (MDs) and inflammatory myopathies (IMs) are debilitating skeletal muscle disorders characterized by common pathological events including myodegeneration inflammation. However, an experimental model representing both pathologies displaying most of the distinctive markers has not been characterized. We investigated cardiotoxin (CTX)-mediated transient acute mouse degeneration compared cardinal features with human MDs IMs. The CTX displayed degeneration, apoptosis,...
Amyotrophic lateral sclerosis (ALS) is a fatal human motor neuron disease leading to muscle atrophy and paralysis. Mutations in superoxide dismutase 1 (SOD1) are associated with familial ALS (fALS). The SOD1 mutants have toxic-gain of function by destabilizing the functional homodimer, consequently inducing fibril-like aggregation cytotoxic non-native trimer intermediate. Therefore, reducing oligomerization via chemical modulators an optimal therapy ALS. Here, we report discovery...
In an effort to understand the role of linker histone in chromatin folding, its structure and location nucleosome has been studied by molecular modeling methods. The globular domain rat H1d, a highly conserved part histone, built homology methods, revealed three‐helical bundle fold that could be described as helix–turn–helix variant with characteristic properties binding DNA at major groove. Using information preferential four‐way Holliday junction (HJ) DNA, model complexed HJ was built,...