A5034158149- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
- Cardiac Arrhythmias and Treatments
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Toxin Mechanisms and Immunotoxins
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Venomous Animal Envenomation and Studies
- Mass Spectrometry Techniques and Applications
Medizinische Hochschule Hannover
2020-2024
Fraunhofer Institute for Toxicology and Experimental Medicine
2024
Heart failure (HF) is a burgeoning health problem worldwide. Often arising as result of cardiac injury, HF has become major cause mortality with limited availability effective treatments. Ferroptotic pathways, triggering an iron-dependent form cell death, are known to be potential key players in heart disease. This death does not exhibit typical characteristics programmed and mediated by impaired iron metabolism lipid peroxidation signalling.
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in heart. Plasticity and activation hallmarks of rcMACs response to changes microenvironment, which is essential for vitro experimentation. The vivo investigation confounded by infiltration other hindering direct studies rcMACs. As a tool investigate rcMACs, we applied ex model living myocardial slices (LMS). LMS ultrathin multicellular preparations circulatory network interrupted. absence this enables...
Abstract Ventricular tachyarrhythmia (VTA) are frequent arrhythmias in patients with hypertrophic cardiomyopathy (HCM). Representing a major risk factor for sudden cardiac death, Holter ECG at first clinical presentation appears insufficient. This study aims to investigate the ability of routinely obtained parameters associated myocardial remodeling stratifying VTA HCM. In this monocentric analysis, HCM underwent 12-channel electrocardiography and echocardiography, including tissue doppler...
Abstract Cardiovascular disease is a global health burden. To develop novel treatment options complex in vitro model systems are needed that resemble the pathophysiological situation ex vivo. Nevertheless, current pre-clinical models for pharmacological research limited complexity. Basic cell culture lack cardiac tissue architecture and intercellular communication, limiting their translational capability. Force measurement methods on vivo cultured living myocardial slices (LMS) have been...
Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply and myocardial hypoxia lead to tissue damage impairment function. To best our knowledge, primary functional effects in multicellular model living slices (LMSs) have not been investigated so far. In this study, we analyzed force generation, ultrastructure, gene expression, proteome changes rat LMS after 24 h ex vivo culture normal reduced levels (O2). We observed a significant reduction absolute slowdown...