A5034088621- Extracellular vesicles in disease
- Circular RNAs in diseases
- Asthma and respiratory diseases
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Food Allergy and Anaphylaxis Research
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Soft tissue tumor case studies
- Macrophage Migration Inhibitory Factor
- Oral and Maxillofacial Pathology
- Anesthesia and Neurotoxicity Research
- Bacterial Infections and Vaccines
- Pharmaceutical studies and practices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Tuberculosis Research and Epidemiology
Medizinische Hochschule Hannover
2020-2024
Maastricht University
2018-2022
Générale de Santé
1991
Hôpital Sainte-Marguerite
1991
Hôpital Cochin
1989
As mediators of intercellular communication, extracellular vesicles containing molecular cargo, such as microRNAs, are secreted by cells and taken up recipient to influence their cellular phenotype function. Here we report that cardiac stress-induced differential microRNA content, with miR-200c-3p being one the most enriched, in cardiomyocyte-derived mediates functional cross-talk endothelial cells. Silencing mice subjected chronic increased pressure overload resulted attenuated hypertrophy,...
Ischemic heart disease (IHD) is one of the world's foremost killers, accounting for 16% all deaths worldwide. IHD main cause failure (HF), as it leads to pathological changes in heart, improper pumping function and eventual death. Therapeutic interventions usually follow a systemic general strategy subtypes due lack deep understanding mechanisms. Hence, HF therapeutics need groundbreaking concepts guide development new class that tackles at molecular level. The TRAIN-HEART consortium, Marie...
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in heart. Plasticity and activation hallmarks of rcMACs response to changes microenvironment, which is essential for vitro experimentation. The vivo investigation confounded by infiltration other hindering direct studies rcMACs. As a tool investigate rcMACs, we applied ex model living myocardial slices (LMS). LMS ultrathin multicellular preparations circulatory network interrupted. absence this enables...
Although studies of families, inbred populations and twins have established that asthma has a hereditary basis, little evidence shown intrinsic an increased familial occurrence. To document this issue, we compared the prevalence in families asthmatics, extrinsic asthmatics non‐asthmatics. The group included those with negative skin tests to common aero‐allergens ( n = 117). one or more positive 164). non‐asthmatic 224) was recruited at check‐up center. siblings each subject completed...
While cardiomyocytes (CMs) have been the main subject of extensive research, role other cardiac cell types, such as fibroblasts and endothelial cells (ECs), received considerable less attention in pathogenesis heart failure (HF). MiRNAs recently emerged mediators paracrine signaling by being selectively incorporated exosomes exchanged between different types. The aim our study is to investigate a potential miRNA crosstalk CMs ECs assess consequences transfer for vascular remodeling under...
Cardiac macrophages (cMφ) play a critical role in cardiac remodeling following myocardial infarction (MI). Reprogramming cMφ towards favorable wound-healing phenotype is emerging as promising therapeutic strategy for MI patients. Circular RNAs (circRNAs) are unique class of non-coding with high stability and abundance, making them attractive targets. However, the circRNAs physiology during heart failure (HF) progression poorly understood. To identify key regulators dynamics, we performed RNA...