A5058374035- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Pancreatic function and diabetes
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pituitary Gland Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- SARS-CoV-2 and COVID-19 Research
- Regulation of Appetite and Obesity
- Nerve injury and regeneration
MultiMedica
2009-2024
University of Milan
2005-2024
University of Udine
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2023
Bouty (Italy)
2021
Columbia University
2001-2010
IRCCS Humanitas Research Hospital
2007-2009
Columbia University Irving Medical Center
2005-2008
Case Western Reserve University
2008
IRCCS Istituto Auxologico Italiano
2006
Previous studies suggested that blockade of RAGE in diabetic apolipoprotein (apo) E-null mice suppressed early acceleration atherosclerosis. A critical test the potential applicability to clinical settings was its ability impact established vascular disease. In this study, we tested hypothesis contributed lesion progression atherosclerosis apoE-null mice.Male mice, age 6 weeks, were rendered with streptozotocin or treated citrate buffer. At 14 certain killed once-daily murine soluble...
Because recent epidemiologic evidence suggests that periodontal infections may increase the risk of atherosclerosis and related events in humans, we assessed impact oral inoculation with pathogen Porphyromonas gingivalis on atherogenesis hypercholesterolemic apolipoprotein E-null mice.In absence alterations distinct factors, P infection exacerbated early stages this model. Infected animals displayed local infection, as severity alveolar bone loss, hallmark periodontitis, was increased....
Abstract —Advanced glycation end products (AGEs) and their cell surface receptor, RAGE, have been implicated in the pathogenesis of diabetic complications. Here, we studied role RAGE expression its proinflammatory ligands, EN-RAGEs (S100/calgranulins), inflammatory events mediating cellular activation tissue. Apolipoprotein E–null mice were rendered with streptozotocin at 6 weeks age. Compared nondiabetic aortas kidneys, kidneys displayed increased EN-RAGEs, 2 key markers vascular...
Background— The beneficial effects of reperfusion therapies have been limited by the amount ischemic damage that occurs before reperfusion. To enable development interventions to reduce cell injury, our research has focused on understanding mechanisms involved in cardiac death after ischemia/reperfusion (I/R) injury. In this context, laboratory investigating role receptor for advanced-glycation end products (RAGE) myocardial I/R Methods and Results— study we tested hypothesis RAGE is a key...
AimsVolume overload and venous congestion are typically viewed as a consequence of advanced acute heart failure (HF) renal (RF) although it is possible that hypervolaemia itself might be critical intermediate in the pathophysiology these diseases. This study aimed at elucidating whether peripheral sufficient to promote changes inflammatory, neurohormonal, endothelial phenotype similar those observed HF RF.
Early growth response-1 (Egr-1) regulates expression of proinflammatory and procoagulant genes in acute cell stress. Experimental evidence suggested that Egr-1 transcripts were upregulated human atherosclerotic plaques versus adjacent unaffected tissue. To test the impact chronic vascular stress, we examined its role a murine model atherosclerosis. Real-time PCR analysis aortae retrieved from apoE −/− mice demonstrated increased an age-dependent manner, compared with C57BL/6 control animals....
Axotomy of peripheral nerve stimulates events in multiple cell types that initiate a limited inflammatory response to axonal degeneration and simultaneous outgrowth neurites into the distal segments after injury. We found pharmacological blockade RAGE impaired regeneration mice subjected acute crush sciatic nerve. As our studies revealed was expressed axons infiltrating mononuclear phagocytes upon injury, we tested role these distinct on regeneration. Transgenic expressing signal...
Subjects with diabetes experience an increased risk of myocardial infarction and cardiac failure compared nondiabetic age-matched individuals. The receptor for advanced glycation end products (RAGE) is upregulated in diabetic tissues. In this study, we tested the hypothesis that RAGE affected ischemia/reperfusion (I/R) injury myocardium. rat hearts, expression its ligands was enhanced localized particularly to both endothelial cells mononuclear phagocytes.To specifically dissect impact RAGE,...
To test the hypothesis that simultaneous administration of GLP-1 and insulin may increase their vasodilatory, antiinflammatory, antioxidant action in type 2 diabetes.In two groups persons with diabetes, sets experiments were performed. The first group had normoglycemic-normoinsulinemic clamps or without normoglycemic-hyperinsulinemic GLP-1. second hyperglycemic-normoinsulinemic hyperglycemic-hyperinsulinemic GLP-1.During clamp, flow-mediated dilatation (FMD) increased, while soluble...
In type 2 diabetes, acute hyperglycemia worsens endothelial function and inflammation,while resistance to GLP-1 action occurs. All these phenomena seem be related the generation of oxidative stress. A Mediterranean diet, supplemented with olive oil, increases plasma antioxidant capacity, suggesting that its implementation can have a favorable effect on aforementioned phenomena. present study, we test hypothesis diet using oil counteract effects improve endothelium action. Two groups diabetic...
OBJECTIVE To test the hypothesis that acute hypoglycemia induces endothelial dysfunction and inflammation through generation of an oxidative stress. Moreover, to if antioxidant vitamin C can further improve protective effects glucagon-like peptide 1 (GLP-1) on during in type 1diabetes. RESEARCH DESIGN AND METHODS A total 20 diabetic patients underwent four experiments: a period 2 h with or without infusion GLP-1 both. At baseline, after h, glycemia, plasma nitrotyrosine, 8-iso prostaglandin...