A5053450219- CAR-T cell therapy research
- bioluminescence and chemiluminescence research
- Cancer Risks and Factors
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Complement system in diseases
- Neutropenia and Cancer Infections
- CRISPR and Genetic Engineering
- Interprofessional Education and Collaboration
- Renal Diseases and Glomerulopathies
- Virus-based gene therapy research
- Metastasis and carcinoma case studies
- Epilepsy research and treatment
- Colorectal Cancer Treatments and Studies
- Vitamin D Research Studies
- Asthma and respiratory diseases
- Cancer Diagnosis and Treatment
- Nanowire Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS drug development and treatment
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Blood groups and transfusion
The Ohio State University
2023-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2024
University of Southern California
2016-2019
Metropolitan Hospital Center
2017-2018
New York Medical College
2017
Northwell Health
2002
Abstract A simple, accurate, sensitive and robust assay that can rapidly specifically measure the death of target cells would have applications in many areas biomedicine particularly for development novel cellular- immune-therapeutics. In this study, we describe a cytotoxicity assay, termed Matador which takes advantage extreme brightness, stability glow-like characteristics recently discovered marine luciferases their engineered derivatives. The involves expression luciferase interest...
Abstract Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies. One of the challenges field is lack a simple assay for detection CARs on surface immune effector cells. In this study, we describe novel luciferase-based assay, termed Topanga Assay, CAR expression. The utilizes recombinant fusion protein, called reagent, generated by joining extra-cellular domain CAR-target frame with one marine luciferases or their engineered...
Management of Immune-Related Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update RELEASE DATE: November 1, 2021 PRIOR VERSION(S): February 14, 2018 DEVELOPER: American Society Clinical Oncology FUNDING SOURCE: TARGET POPULATION: Adult patients cancer receiving treatment immune checkpoint blockade inhibitors alone.
Thrombotic thrombocytopenic purpura (TTP) is a part of spectrum thrombotic microangiopathy syndromes which are mainly characterized by platelet aggregation causing microangiopathic hemolytic anemia, thrombocytopenia and microvascular occlusion. In literature, very few cases expressing direct association between pre-existing Grave's disease TTP have been described. A 37-year-old African-American woman with past medical history polysubstance abuse who presented complaints dyspnoea at rest...
11579 Background: The rarity of sarcoma cancers and the debilitating effects chemotherapy often lead to challenges in quality life for these patients. Uncontrolled symptoms can cause unplanned hospital admissions emergency room visits that delay treatment regimens negatively impact patient outcomes. To assess patients' physical mental well-being during treatment, we used validated tools like PROMIS Global Health v1.2 (PROMIS-10) surveys. We sought expand our cohort patients with advanced...
Abstract Background Mucosal melanoma, an aggressive type of malignancy different from the cutaneous melanomas commonly seen in head and neck region, represents < 1% all malignant melanomas. The pathogenesis mucosal melanoma is unknown. Targetable mutations such as BRAF NRAS genes, have a lower incidence melanoma. carries distinct mutational pattern Surgery with negative margins first-line treatment for systemic therapy not well defined. Talimogene laherparepvec, oncolytic viral...
Acute Liver Failure (ALF) is defined by the presence of acute liver injury, hepatic encephalopathy and elevated prothrombin time/international normalized ratio (INR) in a patient without cirrhosis or preexisting disease, with duration illness less than 26 weeks. The disease often has poor outcome. causes ALF include drug induced viral, ischemic, autoimmune hepatitis. Valproic acid, commonly used anticonvulsant, been associated children adults. A 54 year old African American male was...
e12553 Background: There have been numerous studies conducted linking Vitamin D deficiency to various cancers, including cancers of the breast. Studies associating and Breast cancer shown mixed results in patients with no clear consensus. Recently published vitro that active form can inhibit metastatic capability breast cell lines bone. Based on this we aimed elucidate whether there exists any correlation between at diagnosis Metastatic cancer. Methods: Retrospective analysis EMR for women...